Why might estriol be chosen over estradiol for facial skincare?
Estriol is often chosen over estradiol for facial skincare because it is a gentler, less potent form of estrogen that works effectively at the skin’s surface without entering the bloodstream. Here at Alloy, we use estriol in our M4 skincare line because:
- Estriol is highly effective at boosting collagen, restoring moisture, and improving elasticity—key factors that decline during perimenopause and menopause.
- Topical estriol acts locally, so it does not impact blood estrogen levels, making it safe for everyday use and suitable even if you are not a candidate for systemic hormone therapy.
- Early studies and clinical trials have shown that estriol is particularly effective for skin health, helping to maintain thickness, hydration, and resilience.
- Estriol is more gentle than estradiol, reducing the risk of unwanted systemic effects while still delivering visible anti-aging benefits.
If you want to learn more about the science and see the clinical results, check out our detailed article: What Is Estriol, and What Is Estrogen’s Role in Skin Health?
For a quick video explanation, watch the chapter “Vaginal Estrogen vs. Estriol Face Cream” from our YouTube series, which explains why estriol is the preferred choice for facial skincare: Watch here
Explore our prescription-strength M4 Face Cream Rx and other M4 products to see how estriol can help your skin look and feel its best: M4 Face Cream Rx Product Page
This answer was created using the following resources:
- M4 Face Cream Rx
- M4 Face Serum Rx
- M4 Eye Cream Rx
- Daily Strength Duo
- Advanced Essentials Set
- M4 Core Routine Kit
- Power Pair Set
- Hormones: They're More Than Just Hot Flashes! | Dr. Darwana Ratleff Todd - Estriol’s Unique Benefits for Facial Skin
- Couldn't agree more with Dr. Kelly Casperson! - Estrogen and Skin Health
- What's the Difference Between Estradiol Vaginal Cream and Estriol Face Cream? - Vaginal Estrogen vs. Estriol Face Cream
- What is estrogen's role in health?
- The Science Behind Putting Estrogen On Your Face