M4 Smooth & Firm Rx Priming Serum
$159.00
(90 days of treatment)
M4 Smooth & Firm Rx Priming Serum with Estriol, Peptides, and Hyaluronic Acid is a comprehensive anti-aging treatment that targets fine lines, dryness, and loss of firmness. A powerful blend designed to hydrate, smooth, and visibly renew skin as it ages.
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SAVE 25% WITH THE GLOW & GO SET
Buy all 3 M4 products and save. Learn more
M4 is clinically proven to be powerfully effective
In an independent clinical study, statistically significant improvements seen in M4 Collagen Builder Rx Face Cream compared to placebo in just 12 weeks include:
88%70%68%57%M4 Collagen Builder Rx Face Cream can be used with or without MHT because it does not impact blood estrogen levels.
Learn more about M4 Smooth & Firm Rx Priming Serum
What is it: M4 Smooth & Firm Rx Priming Serum with Estriol, Peptides, and Hyaluronic Acid is a targeted daily dose of rejuvenation. The fragrance-free formula restores hydration and elasticity, boosts collagen production, reduces fine lines and wrinkles, reverses sun damage, enhances skin radiance, improves firmness and smoothness, and supports hormonal skin repair for healthier, more youthful-looking and acting skin.
Full list of ingredients: estriol 0.3%, palmitoyl pentapeptide-4 0.1%, acetyl hexapeptide-8 0.1%, hyaluronic acid 0.5%, cyclopentasiloxane, caprylyl methicone, PEG-16 macadamia glycerides, polysilicone-11, PEG-12 dimethicone/PPG-20 crosspolymer, 1, 2-hexanediol, phosphatidylcholine, jojoba esters, isopropyl jojobate, jojoba alcohol, tocopheryl acetate.
Who is it for: M4 was made for women in perimenopause and menopause—the life stages when hormonal changes start to visibly affect the skin, causing dryness, fine lines, and loss of radiance.
What am I getting: 3-month supply of M4 Smooth & Firm Rx Priming Serum (one 50ml bottle).
How to get it: Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you.
The M4 Difference
Our three powerful M4 products (M4 Collagen Builder Rx Face Cream, M4 Smooth & Firm Rx Priming Serum, and M4 Lift & Renew Rx Eye Cream) boost collagen production, restore hydration, improve elasticity, and support hormonal skin repair, keeping skin resilient, youthful, and balanced.
Each M4 product delivers results on its own—but together, they’re a complete anti-aging powerhouse. Get 25% off when you bundle all three and see what your skin’s been missing. Aging has never looked better.
Did you know?
Up to 30% of dermal collagen is lost in the first 5 years of menopause—with another 2.1% lost every year after.
What is Estriol?
Estriol is one of three forms of estrogen our bodies naturally produce, until menopause. Once we hit menopause, we lose up to 30% of our dermal collagen in the first five years alone. And it only goes down from there. The solution to losing estrogen is replenishing it, and that's where estriol comes in.
Research shows that topical estriol can address hormonal aging and helps keep skin resilient, youthful, and balanced. Topical estriol stays on the surface of your skin and doesn’t enter your bloodstream, making it safe for everyday use.
How it works
Personalize Your Treatment
Fill out a quick intake to share your symptoms and goals
Match With a Doctor
Connect with a board-certified doctor in just hours
Easily Manage Your Plan
Receive a treatment plan tailored to your body, your symptoms, your life
Care Delivered to Your Door
Get your prescriptions sent right to your doorstep
Frequently asked questions
- How do I know if M4 Estriol + Peptide Face Serum is right for me?+
Most women can use M4 Estriol + Peptide Face Serum. Before your doctor prescribes M4 Estriol + Peptide Face Serum, you’ll fill out a quick assessment, and they will review it to make sure it’s right for you.
- Can I use M4 Estriol + Peptide Face Serum with other forms of hormone treatment?+
Yes. You can use M4 Estriol + Peptide Face Serum with Menopausal Hormone Therapy (MHT) and vaginal estrogen, since it is not systemic and therefore not absorbed by your bloodstream.
- Do I need progesterone?+
Because M4 Estriol + Peptide Face Serum is not systemic MHT, you do not need to take progesterone while using it. If you’re already taking progesterone, it’s totally fine to use them together!
- Where is Alloy available?+
All 50 U.S. states and D.C. (Global users can still access our content & resources.)
What our customers are saying:
The Alloy Promise
Alloy believes that every woman deserves accurate, up-to-date information and the agency to make her own decisions about her health based on facts, not fear.
All of our board-certified physicians follow ACOG and The Menopause Society guidelines and prescribe only FDA-approved, generic medications for the treatment of menopausal symptoms. The safety of our products is our top priority.
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