Advanced Essentials Set
$219.97
(90 days of treatment)
This powerful duo—M4 Smooth & Firm Rx Priming Serum and M4 Lift & Renew Rx Eye Cream—combines prescription-strength estriol, peptides, and hyaluronic acid to hydrate, firm, and visibly rejuvenate skin. Together, they boost collagen and elasticity, smooth fine lines, brighten, and support hormonal skin repair for healthier, more youthful-looking skin.
Free shipping
Unlimited messaging with a menopause-trained doctor
SAVE $30 WITH THE ADVANCED ESSENTIALS SET
Purchase both M4 Smooth & Firm Rx Priming Serum and M4 Lift & Renew Rx Eye Cream and save.
The results are in on M4 Lift & Renew Rx Eye Cream
In a 2025 independent clinical study, statistically significant improvements* seen in M4 Lift & Renew Rx Eye Cream in a 12-week study include:
25%33%40%40%M4 Lift & Renew Rx Eye Cream can be used with or without MHT because it does not impact blood estrogen levels. *Based on expert assessment
Learn more about the Advanced Essentials Set
What is it: The Advanced Essentials Set includes M4 Smooth & Firm Rx Priming Serum and M4 Lift & Renew Rx Eye Cream, our new powerful estrogen-based innovations. You’ll save $30 when you buy them together.
Who is it for: Women looking to fight signs of aging due to estrogen deficiency
What am I getting: 3-month supply of M4 Smooth & Firm Rx Priming Serum (one 50ml bottle) and M4 Lift & Renew Rx Eye Cream (one 15ml bottle).
How to get it: Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you.
Did you know?
Up to 30% of dermal collagen is lost in the first 5 years of menopause—with another 2.1% lost every year after.
What is Estriol?
Estriol is one of three forms of estrogen our bodies naturally produce, until menopause. Once we hit menopause, we lose up to 30% of our dermal collagen in the first five years alone. And it only goes down from there. The solution to losing estrogen is replenishing it, and that's where estriol comes in.
Research shows that topical estriol can address hormonal aging and helps keep skin resilient, youthful, and balanced. Topical estriol stays on the surface of your skin and doesn’t enter your bloodstream, making it safe for everyday use.
How it works
Personalize Your Treatment
Fill out a quick intake to share your symptoms and goals
Match With a Doctor
Connect with a board-certified doctor in just hours
Easily Manage Your Plan
Receive a treatment plan tailored to your body, your symptoms, your life
Care Delivered to Your Door
Get your prescriptions sent right to your doorstep
Frequently asked questions
- Are the M4 products right for me?+
Most women are good candidates. A doctor will confirm after a quick assessment.
- Can I use them with hormone therapy?+
Yes—all M4 products are non-systemic and safe with MHT and vaginal estrogen.
- Do I need progesterone?+
No—because M4 is not systemic, progesterone is not required.
- Where is Alloy available?+
All 50 U.S. states and D.C. (Global users can still access our content & resources.)
What our customers are saying:
The Alloy Promise
Alloy believes that every woman deserves accurate, up-to-date information and the agency to make her own decisions about her health based on facts, not fear.
All of our board-certified physicians follow ACOG and The Menopause Society guidelines and prescribe only FDA-approved, generic medications for the treatment of menopausal symptoms. The safety of our products is our top priority.
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