Power Pair Set
$210.00
(90 days of treatment)
Together, this pair delivers a full-spectrum routine ideal for midlife skin. M4 Collagen Builder Rx Face Cream with Estriol and Vitamin E boosts collagen production, restores hydration, and improves elasticity. Anti-Aging Rx Tretinoin with Niacinamide and Aloe gives skin a more youthful look and feel.
Free shipping
Unlimited messaging with a menopause-trained doctor
SAVE $30 WITH THE POWER PAIR SET
Pair M4 Collagen Builder with Anti-Aging Rx Tretinoin to target aging from the inside out—smarter skincare, better results, and built-in savings.
M4 is clinically proven to be powerfully effective
In an independent clinical study, statistically significant improvements seen in M4 Collagen Builder Rx Face Cream compared to placebo in just 12 weeks include:
88%70%68%57%M4 Collagen Builder Rx Face Cream can be used with or without MHT because it does not impact blood estrogen levels.
Learn more about the Power Pair Set
What is it: The Power Pair Set includes M4 Collagen Builder Rx Face Cream with Estriol and Vitamin E and Anti-Aging Rx Tretinoin with Niacinamide and Aloe. Use Tretinoin to smooth and renew the surface plus reduce signs of sun damage, and estriol to rebuild and fortify deeper layers to make skin look and feel younger.
Who is it for: Women looking to fight signs of aging due to estrogen deficiency.
What am I getting: 3-month supply of M4 Collagen Builder Rx Face Cream (one 50ml bottle) and Anti-Aging Rx Tretinoin (Alloy offers three different strengths of Tretinoin to address individual skin needs).
How to get it: Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you.
Did you know?
Up to 30% of dermal collagen is lost in the first 5 years of menopause—with another 2.1% lost every year after.
Science-backed ingredients
What is Estriol?
Estriol is one of three forms of estrogen our bodies naturally produce, until menopause. Once we hit menopause, we lose up to 30% of our dermal collagen in the first five years alone. And it only goes down from there. The solution to losing estrogen is replenishing it, and that's where estriol comes in.
Research shows that topical estriol can address hormonal aging and helps keep skin resilient, youthful, and balanced. Topical estriol stays on the surface of your skin and doesn’t enter your bloodstream, making it safe for everyday use.
What is Tretinoin?
Tretinoin as a topical skin treatment isn’t new. It’s been used to treat mild to moderate acne for almost 50 years. Tretinoin is also known as retinoic acid, and it’s the generic name for synthetic vitamin A.
Anti-Aging Rx Tretinoin is a prescription-strength topical cream or gel that is used mainly to treat acne, fine lines, hyperpigmentation, and discoloration. Tretinoin is able to speed up the life cycle of skin cells, making them divide faster and die faster, so newer, healthier cells can take their place.
Ingredients
M4 Collagen Builder Rx Face Cream ingredients: estriol, C12-15 alkyl benzoate, caprylic/capric triglyceride, cetyl alcohol, ethylhexylglycerin, glycerin, glyceryl stearate, hydroxyethyl acrylate/sodium, acryloyldimethyl taurate copolymer, oleic acid, olea europaea (olive) fruit oil, PEG-100 stearate, phenoxyethanol, dimethicone, polymethylsiloxane, water (aqua), stearic acid, trolamine, vitamin E acetate; Anti-Aging Rx Tretinoin ingredients: Tretinoin, aloe, niacinamide, C13-15 alkane, caprylyl methicone, cyclopentasiloxane, diethylene glycol gonoethyl ether, dimethicone, dimethyl isosorbide, moringa oil/hydrogenated moringa oil esters, passiflora edulis seed oil, PEG-12 dimethicone/PPG-20 crosspolymer, pentaerythrityl tetraisostearate, polysilicone-11, tocopherol, and tocopheryl acetate.
How it works
Personalize Your Treatment
Fill out a quick intake to share your symptoms and goals
Match With a Doctor
Connect with a board-certified doctor in just hours
Easily Manage Your Plan
Receive a treatment plan tailored to your body, your symptoms, your life
Care Delivered to Your Door
Get your prescriptions sent right to your doorstep
Frequently asked questions
- How do I know if M4 Collagen Builder Rx Face Cream is right for me?+
Most women are good candidates. A doctor will confirm after a quick assessment.
- Can I use it with hormone therapy?+
Yes—all M4 products are non-systemic and safe with MHT and vaginal estrogen.
- Do I need progesterone?+
No—because M4 is not systemic, progesterone is not required.
- How do I know if Anti-Aging Rx Tretinoin is right for me?+
Your menopause-trained doctor will review your intake and help determine if Tretinoin is right for you.
- Can I use Tretinoin with Menopausal Hormone Therapy?+
Tretinoin is safe to use with any of Alloy’s options for Menopausal Hormone Therapy, vaginal estradiol, and M4. Your doctor will review all of the medications you’re taking before prescribing and determine if Tretinoin is right for you.
- What is Tretinoin and why is it prescribed?+
Tretinoin is a retinoid derived from vitamin A. It is used to treat acne, fine lines and wrinkles, discoloration, and hyperpigmentation.
- Where is Alloy available?+
All 50 U.S. states and D.C. (Global users can still access our content & resources.)
What our customers are saying:
The Alloy Promise
Alloy believes that every woman deserves accurate, up-to-date information and the agency to make her own decisions about her health based on facts, not fear.
All of our board-certified physicians follow ACOG and The Menopause Society guidelines and prescribe only FDA-approved, generic medications for the treatment of menopausal symptoms. The safety of our products is our top priority.
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