M4 cover
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Best for addressing signs of aging


A restorative estriol face cream to address signs of aging like decreased collagen production, increased wrinkles, and dryness.

$149.97 ($49.99 / month)

  • Prescription included

  • Free shipping, cancel anytime

  • Unlimited messaging with a menopause-trained doctor

Get M4

Did you know?

Up to 30%

of dermal collagen is lost during the first 5 years of menopause and decreases by an additional 2.1% every year after.

Learn more about M4

What is it: M4 is a prescription estrogen-based face cream created specifically for perimenopausal and menopausal women. Active ingredients include topical estriol (addresses signs of aging), glycerin (an excellent humectant), oleic acid (moisturizes, anti-inflammatory, and rich in antioxidants), and vitamin E (softens skin, provides UV protection, and moisturizes).

Who is it for: For any woman–really, any woman–looking to reverse the effects of estrogen-deficiency in the skin due to menopause, perimenopause, or just aging (loss of collagen, decreased elasticity and moisture, and appearance of wrinkles).

What am I getting: One tube of M4 contains a 3-month supply (1.52 oz /45ml).