M4 Face Cream
$49.99 per month (sold in a 3-month supply)
A fragrance-free restorative estriol face cream to address signs of aging like decreased collagen production, reduced elasticity, and dryness.
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Unlimited messaging with a menopause-trained doctor
Save $10 per month with Tretinoin Face Cream
Save when you purchase M4 Face Cream and Tretinoin Face Cream together. Learn more
M4 is clinically proven safe and effective
In an independent clinical study, statistically significant improvements seen in M4 Cream compared to placebo in just 12 weeks include:
88%70%68%57%M4 can be used with or without MHT because it does not impact blood estrogen levels.
Read the full clinical studyLearn more about M4
What is it: M4 is a fragrance-free, prescription, estrogen-based, face cream, created specifically for perimenopausal and menopausal women. The active ingredient is topical estriol to address signs of aging.
Full list of ingredients: estriol, aloe barbadensis leaf juice , C 12 - 14 isoparaffin, caprylic/capric triglyceride, deionized water, laureth-7, phenoxyethanol, polyacrylamide, tocopheryl acetate, and triethylene glycol.
Who is it for: For any woman–really, any woman–looking to reverse the effects of estrogen-deficiency in the skin due to menopause, perimenopause, or just aging (loss of collagen, decreased elasticity, and dryness).
What am I getting: One bottle of M4 contains a 3-month supply (45ml).
How to get it: Prescription required. One of our menopause-trained doctors will review your medical history to determine if this is the right treatment for you.
M4 + Tretinoin Cream = the perfect combo for radiant skin
As your body stops producing estrogen, your skin loses its collagen. You also might experience decreased elasticity and moisture, fine lines, and wrinkles.
Use M4 to increase collagen, hydration, firmness, and radiance. Tretinoin will swoop in to increase cell turnover and give your skin a more youthful look & feel.
We love 'em both, but they're better together. Get $30 off when you buy Tretinoin Face Cream with M4.
Get the skincare bundle
Did you know?
Up to 30% of dermal collagen is lost during the first five years of menopause, and it decreases by an extra 2.1% every year after.
What is Estriol?
Estriol is one of three forms of estrogen our bodies naturally produce...until menopause. Once we hit menopause, we lose up to 30% of our dermal collagen in the first five years alone! And it only goes down from there. The solution to losing estrogen is replenishing it, and that's where estriol comes in.
The research shows that topical estriol can help maintain skin health. Even if you're not a candidate for MHT, you can use estriol face cream, since topical estriol doesn't go into your bloodstream. You also won't experience hormonal side effects.
Read the study
How it works
Take our skin assessment
It should only take about a minute!
Select your treatments
Choose the treatments you'd like to request from the doctor.
Doctor review
A doctor will review and write your prescriptions.
Treatments delivered to your door
We'll ship everything right to you!
Frequently asked questions
- How do I know if M4 is right for me?+Most women can safely use M4. Before we prescribe M4, you’ll fill out a quick assessment, and a doctor will review it to make sure it’s right for you.
- Can I use M4 with other forms of hormone treatment?+Yes. You can use M4 with or without MHT, since it is not systemic and therefore not absorbed by your bloodstream.
- What is tretinoin and why is it prescribed?+Tretinoin is Vitamin A-derived skincare. It can be used to treat acne, fine wrinkles, dark spots, and rough skin. It works by speeding up cell turnover.
- Do I need progesterone?+Because M4 is not systemic MHT, you do not need to take progesterone while using it. If you’re already taking progesterone, it’s totally fine to use them together!
- Where is Alloy available?+At this time, Alloy only serves patients in the United States (excluding U.S. territories). However, anyone can access the Alloy community. You can sign up for the newsletter, access the blog and enjoy other free resources, regardless of where you live.
What Alloy customers are saying
“I am amazed at the difference in my face and neck from just two weeks of using M4. My fine lines have almost disappeared and my skin is definitely more supple. The product layers perfectly with my serums and tretinoin and I love that it’s fragrance free.”
“The Estriol face cream is magic. Skin looks plumper. Less dry. Also love the ease and efficiency of obtaining care from the staff and doctors using online questionnaires and prescriptions.”
“I really love the face cream a lot! I have used an estrogen facial moisturizer from other providers before but this one from myalloy is the best. They all have the estrodial but myalloy has a beautiful formulation . The texture is excellent with absolutely no weird sticky or tackiness....it absorbed beautifully and wears under makeup and sunscreen very well. It 100 helps with maintaining moisture, suppleness and plumpness in the skin. My skin barrier is healthy and with that comes a glow to the skin. It is a very elegant formulation that is affordable. Thank you so much!”
The online app is excellent- user friendly, clear and efficient. I received responses from the doctor within an hour of me sending messages. As healthcare provider myself, I was so impressed with the entire experience. I purchased the M4 face cream- saw results within a week. Again. so impressed. And grateful that there is a site out there to help us navigate the waters of peri-menopause/menopause in a way that has been hard for me to find in standard medical practices. Thank you SO much.
I love the M4 Face cream as part of my daily skincare routine. I am an Advanced Practice Esthetician and specialize in peri-post menopausal skin. I have recommended it to many of my clients. It’s such a great addition to what I offer.
The Alloy Promise
Alloy believes that every woman deserves accurate, up-to-date information and the agency to make her own decisions about her health based on facts, not fear.
All of our board-certified physicians follow ACOG and The Menopause Society guidelines and prescribe only FDA-approved, generic medications for the treatment of menopausal symptoms. The safety of our products is our top priority.
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