M4 Estriol Face Cream
$49.99per month
(Sold in a 3-month supply)
A fragrance-free restorative estriol face cream that’s clinically proven to address signs of aging like decreased collagen production, decreased elasticity, and dryness.
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Unlimited messaging with a menopause-trained doctor
Get $10 off per month with Tretinoin Face Cream
Save when you purchase M4 Face Cream and Tretinoin Face Cream together. Learn more
M4 is clinically proven to be safe and effective
In an independent clinical study, statistically significant improvements seen in M4 Cream compared to placebo in 12 weeks include:
88%70%68%57%M4 can be used with or without MHT because it does not impact blood estrogen levels.
Read the full clinical studyLearn more about M4 Estriol Face Cream
What is it: M4 Estriol Face Cream is a clinically proven, fragrance-free, prescription, estrogen-based face cream we created specifically for perimenopausal and menopausal women. The active ingredient is topical estriol, which improves collagen production and helps to address signs of aging.
Full list of ingredients: estriol, C12 - 15 alkyl benzoate, caprylic/capric triglycerides, cetyl alcohol, ethylhexylglycerin, glycerin USP, glyceryl stearate, hydroxyethyl acrylate/sodium acryloyldimethyl, a taurate copolymer, oleic acid, olive oil, PEG-100 stearate, phenoxyethanol, polymethylsiloxane, purified water, stearic acid, trolamine NF, and vitamin E acetate.
Who is it for: For any woman looking to reverse the effects of estrogen deficiency in the skin due to menopause or perimenopause (loss of collagen, decreased elasticity and moisture).
What am I getting: 3-month supply of M4 Estriol Face Cream (one 45ml bottle).
How to get it: Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you.
M4 + Tretinoin Cream = the perfect combo for radiant skin
As your body stops producing estrogen, your skin loses its collagen. You also might experience decreased elasticity and moisture, fine lines, and wrinkles.
Use M4 to increase collagen, hydration, firmness, and radiance. Tretinoin will swoop in to increase cell turnover and give your skin a more youthful look & feel.
We love 'em on their own, but they're better together. Get $30 off when you buy Tretinoin Face Cream with M4.
Did you know?
Up to 30% of dermal collagen is lost during the first five years of menopause, and it decreases by an extra 2.1% every year after.
What is Estriol?
Estriol is one of three forms of estrogen our bodies naturally produce...until menopause. Once we hit menopause, we lose up to 30% of our dermal collagen in the first five years alone! And it only goes down from there. The solution to losing estrogen is replenishing it, and that's where estriol comes in.
The research shows that topical estriol can help maintain skin health. Topical estriol doesn't go into your bloodstream, so it is safe for everyone to use. You also won't experience hormonal side effects from M4.
How it works
Take our skin assessment
It should only take about a minute!
Select your treatments
Choose the treatments you'd like to request from the doctor.
Doctor review
A doctor will review and write your prescriptions.
Treatments delivered to your door
We'll ship everything right to you!
Frequently asked questions
- How do I know if M4 is right for me?+
Most women can safely use M4. Before we prescribe M4, you’ll fill out a quick assessment, and a doctor will review it to make sure it’s right for you.
- Can I use M4 Estriol Face Cream with other forms of hormone treatment?+
Yes. You can use M4 Estriol Face Cream safely with MHT and vaginal estrogen, since it is not systemic and therefore not absorbed by your bloodstream.
- What is tretinoin and why is it prescribed?+
Tretinoin is Vitamin A-derived skincare. It can be used to treat acne, fine wrinkles, dark spots, and rough skin. It works by speeding up cell turnover.
- Do I need progesterone?+
Because M4 Estriol Face Cream is not systemic MHT, you do not need to take progesterone while using it. If you’re already taking progesterone, it’s totally fine to use them together!
- Is M4 Estriol Face Cream eligible for HSA or FSA reimbursement?+
Yes! Medications prescribed by a licensed provider are eligible to be paid for or reimbursed by your HSA or FSA. Your invoice is available to download and include when you submit to your plan for reimbursement. If you require more information, please contact us at support@myalloy.com and we will assist you. Note: The IRS defines which medical expenses are eligible under an HSA or FSA and the products carried on Alloy are in compliance with these requirements. However, these plans can vary and some may not allow all eligible HSA or FSA expenses. It's important to always check with your benefits administrator to determine which expenses are eligible before you shop.
- Where is Alloy available?+
Alloy is available in all 50 U.S. states, plus Washington, D.C. The only exception is our Weight Care program, which is not available in Mississippi or Louisiana. If you live outside the U.S., you are still welcome in the Alloy community! You can sign up for our newsletter, follow us on social media @myalloy, access our blog, and enjoy our webinars as well as other free resources, regardless of where you live.
What Alloy customers are saying:
The Alloy Promise
Alloy believes that every woman deserves accurate, up-to-date information and the agency to make her own decisions about her health based on facts, not fear.
All of our board-certified physicians follow ACOG and The Menopause Society guidelines and prescribe only FDA-approved, generic medications for the treatment of menopausal symptoms. The safety of our products is our top priority.
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