Meet your simple,
skincare routine


Glow from the inside out!

The perfect one-two combo for healthy, radiant skin

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M4 Face Cream

$149.97 (3-month supply)

Our fragrance-free, custom-blended estriol moisturizer which works to replenish estrogen, increase collagen production, and address signs of aging.
How to use:
Use M4 in the morning or at night after serums, before moisturizers.
tretinoin-face-creamrx item

Tretinoin Face Cream

$30 off with purchase of m4
$60.00 $90.00 (3-month supply)

Our fragrance-free topical treatment for acne, fine lines, hyperpigmentation, and discoloration.
How to use:
Use Tretinoin after moisturizer as part of your night time routine.

Science-backed ingredients



Increases collagen production, retains and restores skin moisture, increases skin firmness, increases skin elasticity, decreases pore size, and decreases wrinkle depth.


Estriol, aloe barbadensis leaf juice , C 12 - 14 isoparaffin, caprylic/capric triglyceride, deionized water, laureth-7, phenoxyethanol, polyacrylamide, tocopheryl acetate, and triethylene glycol.


Did you know?

Up to 30% of dermal
collagen is lost during
the first 5 years of
menopause, and
decreases by an extra
every year after.

Reverse the effects of estrogen deficiency

Perimenopause, menopause, and aging mean estrogen deficiency. Estrogen deficiency means loss of collagen, decreased elasticity and moisture, and the appearance of wrinkles. Our skincare was specially formulated to

  • Plump and firm skin
  • Shrink the appearance of pores
  • Alleviate dryness and dullness
  • Restore elasticity for a rejuvenated complexion

What Alloy customers are saying

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“I really love the face cream a lot! I have used an estrogen facial moisturizer from other providers before but this one from myalloy is the best. They all have the estrodial but myalloy has a beautiful formulation . The texture is excellent with absolutely no weird sticky or absorbed beautifully and wears under makeup and sunscreen very well. It 100 helps with maintaining moisture, suppleness and plumpness in the skin. My skin barrier is healthy and with that comes a glow to the skin. It is a very elegant formulation that is affordable. Thank you so much!”

Kim on Trustpilot
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“The M4 cream is fantastic. It was delivered straight to my door and I am noticing great benefits to my face and neck. It’s so hard to find providers who are up to date on menopause care. Thanks Alloy!”

Alyssa on Trustpilot
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“I am amazed at the difference in my face and neck from just two weeks of using M4. My fine lines have almost disappeared and my skin is definitely more supple. The product layers perfectly with my serums and tretinoin and I love that it’s fragrance free.”

Michelle on Trustpilot
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“The M4 cream is fragrance-free and has enhanced my facial dryness and dullness almost immediately. My Mom always says, "your face looks brighter and healthier."

Kim on Trustpilot
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“The Estriol face cream is magic. Skin looks plumper. Less dry. Also love the ease and efficiency of obtaining care from the staff and doctors using online questionnaires and prescriptions.”

KimTX on Trustpilot

How it works


Take our skin assessment

It should only take about a minute!


Select your treatments

Choose the treatments you’d like to request from the doctor.


Doctor review

A doctor will review and write your prescriptions.


Treatments delivered to your door

We’ll ship everything right to you!

Related Research

Gehring, W. “Nicotinic Acid/Niacinamide and the Skin.” Journal of Cosmetic Dermatology, vol. 3, no. 2, Apr. 2004, pp. 88–93,

Griffiths, Christopher E. M. “Two Concentrations of Topical Tretinoin (Retinoic Acid) Cause Similar Improvement of Photoaging but Different Degrees of Irritation.” Archives of Dermatology, vol. 131, no. 9, 1 Sept. 1995, p. 1037,

Hajheydari, Z., et al. “Effect of Aloe Vera Topical Gel Combined with Tretinoin in Treatment of Mild and Moderate Acne Vulgaris: A Randomized, Double-Blind, Prospective Trial.” Journal of Dermatological Treatment, 2014,

Lephart ED, Naftolin F. Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin. Dermatol Ther (Heidelb). 2021 Feb;11(1):53-69. doi: 10.1007/s13555-020-00468-7. Epub 2020 Nov 26. PMID: 33242128; PMCID: PMC7859014.

Rzepecki AK, Murase JE, Juran R, Fabi SG, McLellan BN. Estrogen-deficient skin: The role of topical therapy. Int J Womens Dermatol. 2019 Mar 15;5(2):85-90. doi: 10.1016/j.ijwd.2019.01.001. PMID: 30997378; PMCID: PMC6451761.

Sitohang, Irma Bernadette S., et al. “Topical Tretinoin for Treating Photoaging: A Systematic Review of Randomized Controlled Trials.” International Journal of Women’s Dermatology, vol. 8, no. 1, Mar. 2022, p. e003,