What evidence supports estriol-based face creams for menopausal skin?

There is strong clinical evidence supporting the use of estriol-based face creams for menopausal skin. Here at Alloy, we developed the M4 Face Cream Rx specifically for women in perimenopause and menopause, when declining estrogen leads to rapid loss of collagen, hydration, and skin elasticity.

Key evidence includes:

A 2024 independent, double-blind, placebo-controlled clinical study of M4 Face Cream Rx showed statistically significant improvements in just 12 weeks:
- 88% improvement in skin elasticity
- 70% improvement in hydration
- 68% improvement in overall skin health
- 57% improvement in skin texture
The study confirmed no increase in systemic estrogen levels, making it safe for everyday use.
Estriol, the active ingredient, is a gentle, less potent form of estrogen that works locally to boost collagen, restore moisture, and improve elasticity—counteracting the effects of estrogen loss on the skin.
These results are supported by published research, such as:
- Lephart & Naftolin (2020), Dermatology and Therapy: Topical estrogens improve skin thickness, moisture, and elasticity in estrogen-deficient skin.
- Schmidt et al. (1996), International Journal of Dermatology: Topical estrogens significantly improve signs of skin aging.

You can read the full clinical study on M4 Face Cream Rx here: M4 Clinical Study PDF.

For a helpful video summary of the clinical results, check out the "M4 Estriol Face Cream Study Results" chapter from Dr. Darwana Ratleff Todd on YouTube: Watch the study results here.

If you’re interested in trying M4 Face Cream Rx, you can learn more or start your prescription process here: M4 Face Cream Rx Product Page.

At Alloy, we’re proud to offer science-backed solutions to help your skin stay resilient, hydrated, and youthful throughout menopause.

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