Is topical estriol absorbed systemically?
Topical estriol, as used in Alloy's M4 skincare products, is not absorbed systemically. Clinical studies and safety data confirm that topical estriol stays on the surface of your skin and does not enter your bloodstream, so it does not raise estrogen levels in the body. This makes it safe for everyday use, even for those who are not candidates for menopausal hormone therapy (MHT).
If you want to learn more about the science and clinical results, check out the following resources:
- The Science Behind Putting Estrogen On Your Face
- M4 Face Cream Rx product page
- 2025 Estriol Eye Cream Clinical Study Report
Here at Alloy, we’re proud to offer prescription-strength topical estriol products that deliver visible results for skin health without systemic hormone absorption. If you’re interested in trying these products, you can view the full M4 skincare line here.
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