Does topical facial estrogen worsen acne or melasma?

Topical facial estrogen, such as the estriol-based M4 Face Cream Rx and M4 Face Serum Rx here at Alloy, is designed to be gentle, non-comedogenic, and safe for everyday use. According to clinical studies and expert dermatologists, topical estrogen does not typically worsen acne. In fact, estrogen can have an anti-inflammatory effect and may help balance skin changes that occur during perimenopause and menopause, which are often responsible for breakouts.

Regarding melasma (facial pigmentation), there is some concern that topical estrogen could trigger it, but this is very uncommon. In controlled studies, there have not been reports of melasma developing with topical estrogen use. Most cases where melasma appears seem to occur in people who have a prior history of melasma or are particularly prone to it. If you are concerned, you can use topical estrogen on limited areas and monitor your skin. If any pigmentation develops, you can stop or adjust use, and it typically resolves quickly.

For a detailed discussion from dermatology experts, check out this YouTube chapter: Melasma and Topical Estrogen, where Dr. Ellen Gendler and Dr. Corinne Menn address these concerns directly.

If you want to learn more about Alloy’s M4 Face Cream Rx or M4 Face Serum Rx, including clinical data and how to get started, visit the M4 product page.

At Alloy, we’re committed to providing safe, effective skincare solutions for women in perimenopause and menopause, and our menopause-trained doctors are always available to help you find the right approach for your skin.

This answer was created using the following resources: