I'm 56 and have been using these products for a few months now and am blown away. My skin is soft and hydrated. Big fan bravo @myalloy

Woman in Swimsuit

                    - Susie via Instagram

"I'm 56 and have been using these products for a few months now and am blown away. My skin is soft and hydrated. Big fan. Bravo @myalloy."

M4 Rx FAQ 

Most women are good candidates. A doctor will confirm after a quick assessment.

Are the M4 products right for me?

Yes. You can use M4 Skincare Rx with Menopausal Hormone Therapy (MHT) and vaginal estrogen, since it is not systemic and therefore not absorbed by your bloodstream.

Can I use this with hormone therapy?

In three independent clinical studies (one on M4 Face Cream Rx in 2024 and one on M4 Eye Cream Rx in 2025 & M4 Body Treatment in 2026), results showed statistically significant improvements in hydration, elasticity, firmness, and overall skin health. Efficacy and safety results for these studies were verified by dermatology experts. 

__2024 Study to Assess the Facial Anti-Aging Efficacy of Topical Estriol and Estradiol__

Improvements seen in M4 Face Cream Rx with Estriol compared to placebo in 12 weeks include:
88% improvement in elasticity
70% improvement in hydration
68% improvement in overall skin health
57% improvement in skin texture

__2025 Study to Evaluate the Efficacy of Estriol Eye Cream__

Improvements seen in M4 Eye Cream Rx in 12 weeks include:
Up to 25% wrinkle reduction
Up to 33% firmer looking skin*
Up to 40% more elasticity*
Up to 40% less crepiness on the eyelids*
Immediately boosted hydration by 23%**

__2026 Study to Evaluate the Efficacy of Estriol Body Cream__

Improvements seen in M4 Body Cream Rx on chest and legs in 12 weeks include: 18% improvement in skin hydration upon application
11% less crepiness on the chest
18% smoother skin texture on the chest
11% firmer looking skin on the chest and legs
7% improvement in skin elasticity

*Based on Expert Assessment

**Based on Instrumentation 


What were the results of the clinical studies of M4 products?

M4 was made for women in perimenopause and menopause—the life stages when hormonal changes start to visibly affect the skin causing dryness, fine lines, and loss of radiance. Perimenopause typically begins in your 40s, though it can start as early as your mid-30s.

By age 50, women can lose up to 50% of their total collagen compared to peak levels. If you’re in perimenopause, M4 is a smart way to get ahead of the curve. Topical estriol, the star ingredient in our formulas, helps keep skin resilient, youthful, and balanced—before signs of aging deepen. And if you’re already in menopause, M4 is designed to restore what hormonal shifts have taken away: firmness, hydration, and that healthy glow.

When should I start using the M4 Skincare line?

No—because M4 is not systemic, progesterone is not required.

Do I need progesterone?

Yes! Medications prescribed by a licensed provider are eligible to be paid for or reimbursed by your HSA or FSA. Your invoice is available to download and include when you submit to your plan for reimbursement. If you require more information, please contact us at support@myalloy.com and we will assist you. Note: The IRS defines which medical expenses are eligible under an HSA or FSA and the products carried on Alloy are in compliance with these requirements. However, these plans can vary and some may not allow all eligible HSA or FSA expenses. It's important to always check with your benefits administrator to determine which expenses are eligible before you shop.

Is M4 Rx eligible for HSA or FSA reimbursement?

All 50 U.S. states and D.C. (Global users can still access our content & resources.)

"I'm 56 and have been using these products for a few months now and am blown away. My skin is soft and hydrated. Big fan. Bravo @myalloy."

Frequently asked questions