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Estriol

M4 Face Cream Rx

$150.00

(90 days of treatment)

Estrogen-powered anti-aging cream that hydrates, restores elasticity, and rebuilds collagen. Clinically proven to improve firmness, bounce, and texture in 12 weeks—with up to 88% improvement in elasticity. Gentle and non-comedogenic.

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Unlimited messaging with a menopause-trained doctor

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SAVE 25% WITH THE GLOW & GO SET

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M4 is clinically proven to be powerfully effective

In an independent clinical study, statistically significant improvements seen in M4 Face Cream Rx compared to placebo in just 12 weeks include:

88%

improvement in elasticity

70%

improvement in hydration

68%

improvement in overall skin health

57%

improvement in skin texture

M4 Face Cream Rx can be used with or without MHT because it does not impact blood estrogen levels.

Read the full clinical study

Learn more about M4 Face Cream Rx

What is it: A clinically proven, fragrance-free, prescription, estrogen-based face cream we created specifically for perimenopausal and menopausal women. The combination of increased hydration and collagen stimulation is a major innovation that helps address and prevent signs of aging.

Full list of ingredients: estriol, C12-15 alkyl benzoate, caprylic/capric triglyceride, cetyl alcohol, ethylhexylglycerin, glycerin, glyceryl stearate, hydroxyethyl acrylate/sodium, acryloyldimethyl taurate copolymer, oleic acid, olea europaea (olive) fruit oil, PEG-100 stearate, phenoxyethanol, dimethicone, polymethylsiloxane, water (aqua), stearic acid, trolamine, vitamin E acetate.

Who is it for: M4 was made for women in perimenopause and menopause—the life stages when hormonal changes start to visibly affect the skin, causing dryness, fine lines, and loss of radiance.

What am I getting: 3-month supply of M4 Face Cream Rx (one 50ml bottle).

How to get it: Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you.

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Real Customers Love It

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See Results in as Little as 12 Weeks

The M4 Difference

Our three powerful M4 products (M4 Face Cream Rx, M4 Face Serum Rx, and M4 Eye Cream Rx) boost collagen production, restore hydration, improve elasticity, and support hormonal skin repair, keeping skin resilient, youthful, and balanced.

Each M4 product delivers results on its own—but together, they’re a complete anti-aging powerhouse. Get 25% off when you bundle all three and see what your skin’s been missing. Aging has never looked better.

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Did you know?

Up to 30% of dermal collagen is lost in the first 5 years of menopause—with another 2.1% lost every year after.

Estriol Ingredient

What is Estriol?

Estriol is one of three forms of estrogen our bodies naturally produce, until menopause. Once we hit menopause, we lose up to 30% of our dermal collagen in the first five years alone. And it only goes down from there. The solution to losing estrogen is replenishing it, and that's where estriol comes in.

Research shows that topical estriol can address hormonal aging and helps keep skin resilient, youthful, and balanced. Topical estriol stays on the surface of your skin and doesn’t enter your bloodstream, making it safe for everyday use.

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How it Works

Go from experiencing symptoms to finding solutions in no time.

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Frequently asked questions

The Alloy Promise

Alloy believes that every woman deserves accurate, up-to-date information and the agency to make her own decisions about her health based on facts, not fear.

All of our board-certified physicians follow ACOG and The Menopause Society guidelines and prescribe only FDA-approved, generic medications for the treatment of menopausal symptoms. The safety of our products is our top priority.

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The Alloy Promise