M4 Collagen Builder Rx Face Cream
$150.00
(90 days of treatment)
Estrogen-powered anti-aging cream that hydrates, restores elasticity, and rebuilds collagen. Clinically proven to improve firmness, bounce, and texture in 12 weeks—with up to 88% improvement in elasticity. Gentle and non-comedogenic.
Free shipping
Unlimited messaging with a menopause-trained doctor
SAVE 25% WITH THE GLOW & GO SET
Buy all 3 M4 products and save. Learn more
M4 is clinically proven to be powerfully effective
In an independent clinical study, statistically significant improvements seen in M4 Collagen Builder Rx Face Cream compared to placebo in just 12 weeks include:
88%70%68%57%M4 Collagen Builder Rx Face Cream can be used with or without MHT because it does not impact blood estrogen levels.
Learn more about M4 Collagen Builder Rx Face Cream
What is it: A clinically proven, fragrance-free, prescription, estrogen-based face cream we created specifically for perimenopausal and menopausal women. The combination of increased hydration and collagen stimulation is a major innovation that helps address and prevent signs of aging.
Full list of ingredients: estriol, C12-15 alkyl benzoate, caprylic/capric triglyceride, cetyl alcohol, ethylhexylglycerin, glycerin, glyceryl stearate, hydroxyethyl acrylate/sodium, acryloyldimethyl taurate copolymer, oleic acid, olea europaea (olive) fruit oil, PEG-100 stearate, phenoxyethanol, dimethicone, polymethylsiloxane, water (aqua), stearic acid, trolamine, vitamin E acetate.
Who is it for: M4 was made for women in perimenopause and menopause—the life stages when hormonal changes start to visibly affect the skin, causing dryness, fine lines, and loss of radiance.
What am I getting: 3-month supply of M4 Collagen Builder Rx Face Cream (one 50ml bottle).
How to get it: Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you.
The M4 Difference
Our three powerful M4 products (M4 Collagen Builder Rx Face Cream, M4 Smooth & Firm Rx Priming Serum, and M4 Lift & Renew Rx Eye Cream) boost collagen production, restore hydration, improve elasticity, and support hormonal skin repair, keeping skin resilient, youthful, and balanced.
Each M4 product delivers results on its own—but together, they’re a complete anti-aging powerhouse. Get 25% off when you bundle all three and see what your skin’s been missing. Aging has never looked better.
Did you know?
Up to 30% of dermal collagen is lost in the first 5 years of menopause—with another 2.1% lost every year after.
What is Estriol?
Estriol is one of three forms of estrogen our bodies naturally produce, until menopause. Once we hit menopause, we lose up to 30% of our dermal collagen in the first five years alone. And it only goes down from there. The solution to losing estrogen is replenishing it, and that's where estriol comes in.
Research shows that topical estriol can address hormonal aging and helps keep skin resilient, youthful, and balanced. Topical estriol stays on the surface of your skin and doesn’t enter your bloodstream, making it safe for everyday use.
How it works
Personalize Your Treatment
Fill out a quick intake to share your symptoms and goals
Match With a Doctor
Connect with a board-certified doctor in just hours
Easily Manage Your Plan
Receive a treatment plan tailored to your body, your symptoms, your life
Care Delivered to Your Door
Get your prescriptions sent right to your doorstep
Frequently asked questions
- How do I know if M4 Collagen Builder Rx Face Cream is right for me?+
Most women are good candidates. A doctor will confirm after a quick assessment.
- Can I use this with hormone therapy?+
Yes — M4 Collagen Builder Rx Face Cream is non-systemic and safe with MHT and vaginal estrogen.
- What is Tretinoin and why is it prescribed?+
Tretinoin is a retinoid derived from vitamin A. It is used to treat acne, fine lines and wrinkles, discoloration, and hyperpigmentation.
- Do I need progesterone?+
No—because M4 is not systemic, progesterone is not required.
- Is M4 Estriol Face Cream eligible for HSA or FSA reimbursement?+
Yes! Medications prescribed by a licensed provider are eligible to be paid for or reimbursed by your HSA or FSA. Your invoice is available to download and include when you submit to your plan for reimbursement. If you require more information, please contact us at support@myalloy.com and we will assist you. Note: The IRS defines which medical expenses are eligible under an HSA or FSA and the products carried on Alloy are in compliance with these requirements. However, these plans can vary and some may not allow all eligible HSA or FSA expenses. It's important to always check with your benefits administrator to determine which expenses are eligible before you shop.
- Where is Alloy available?+
All 50 U.S. states and D.C. (Global users can still access our content & resources.)
What our customers are saying:
The Alloy Promise
Alloy believes that every woman deserves accurate, up-to-date information and the agency to make her own decisions about her health based on facts, not fear.
All of our board-certified physicians follow ACOG and The Menopause Society guidelines and prescribe only FDA-approved, generic medications for the treatment of menopausal symptoms. The safety of our products is our top priority.
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