When is the risk-benefit profile of menopausal hormone therapy most favorable?

The risk-benefit profile of menopausal hormone therapy (MHT) is most favorable when started at the time of natural menopause or within 10 years of your last period, and ideally before age 60. This is when you can achieve the greatest benefits—such as relief from hot flashes, prevention of bone loss, and support for heart and brain health—with the lowest risk. Starting MHT later (after age 60 or more than 10 years since menopause) may still offer benefits, but the risk profile changes slightly, and some of the protective effects (especially for the heart and bones) may be reduced.

At Alloy, our menopause-trained clinicians use this evidence-based approach to help you decide if and when MHT is right for you. You can learn more about your options and get a personalized plan by taking our quick online assessment: Alloy Assessment.

For a clear explanation from Dr. Sharon Malone about the optimal timing and risk-benefit ratio of hormone therapy, watch this helpful video segment: Optimal Timing and Risk-Benefit Ratio – Dr. Sharon Malone.

If you’re interested in exploring MHT options, check out our range of products, including estradiol pills, patches, and more on our solutions page. Here at Alloy, we’re committed to helping you feel your best at every stage of menopause.

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This answer was created using the following resources:

• Menopause, Hormones & Your Heart: What You Need to Know | Dr. Jayne Morgan - Menopausal Hormone Therapy and the Critical Window
• When’s the Best Time to Start Hormone Therapy? | Dr. Sharon Malone - Optimal Timing and Risk-Benefit Ratio
• Hormone Therapy 101 (pt.2) | Dr. Corinne Menn - Hormone Therapy After Age 60: The Window of Opportunity
• Your Menopause Questions Answered | Dr. Sharon Malone - Hormone Therapy After Age 60
• Estrogen Therapy: Biohacking for Women
• Menopause Hormone Guide: Expert Insights
• Do You Need Menopause Hormone Therapy?