What specific aspects of the brain have been shown to change across the menopausal transition?

During the menopausal transition, several specific aspects of the brain have been shown to change:

  • Brain Structure: Imaging studies reveal that menopause changes the structure of the brain, including areas involved in memory such as the hippocampus, which is rich in estrogen receptors.
  • Metabolic Activity: The brain’s energy levels and metabolic activity shift, meaning how efficiently the brain uses energy can be altered.
  • Connectivity: The way different parts of the brain communicate with each other changes, which may relate to symptoms like brain fog.
  • Blood Flow: Blood flow to the brain is affected, which can influence cognitive function and overall brain health.
  • Biochemistry: The chemical environment of the brain, including neurotransmitter levels and hormone interactions, is altered during this transition.

These changes are linked to common neurological symptoms of menopause such as brain fog, memory lapses, mood swings, hot flashes, and sleep disturbances. Estradiol (a form of estrogen) is especially important for brain health, acting as a neuroprotective hormone that supports energy production, immune function, blood flow, and neuroplasticity.

If you’d like to learn more, check out our detailed article: This is Your Brain on Menopause, or watch our expert webinar with Dr. Lisa Mosconi and Dr. Sharon Malone on YouTube for an in-depth discussion of these brain changes.

If you’re experiencing symptoms like brain fog or memory issues, managing your hormones can help. Explore Alloy’s menopause treatment options to see how we can support your brain and overall well-being during this transition.


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