How might estrogen changes relate to Alzheimer’s disease risk in some women?
Estrogen changes during perimenopause and menopause are closely linked to Alzheimer’s disease risk in women. Here at Alloy, we want you to know that:
- Two thirds of Alzheimer’s patients are women, and this is not just because women live longer. Research shows that the female brain undergoes structural and metabolic changes starting in perimenopause, well before any cognitive symptoms appear.
- Lowered estrogen states, such as those after menopause or with early/premature menopause, are associated with a higher risk of developing Alzheimer’s. Women who experience menopause before age 45 are at even greater risk, and the North American Menopause Society recommends estrogen therapy for these women at least until the average age of menopause.
- Estrogen, especially estradiol, is considered a “master regulator” or “CEO” of the female brain. It supports brain energy, neuroprotection, blood flow, and immune function. When estrogen levels drop, these protective effects diminish, potentially increasing vulnerability to neurodegenerative changes.
- Timing matters: Starting menopausal hormone therapy (MHT) early (within five years of menopause) may help reduce Alzheimer’s risk, while starting much later does not show the same benefit and may even be harmful.
- Recent studies suggest that MHT can reduce biomarkers associated with Alzheimer’s, and women who start hormone therapy in midlife may have a reduced risk of future Alzheimer’s disease.
For a deeper dive into this topic, check out our article: Exciting News about Estrogen and Alzheimer’s.
You might also enjoy our expert-led webinar with Dr. Lisa Mosconi and Dr. Sharon Malone, which covers menopause, brain health, and Alzheimer’s risk. Watch the full discussion on YouTube: This is Your Brain on Menopause.
If you’re interested in exploring hormone therapy options to support your brain and overall health during menopause, visit our product page to see what’s available and connect with a menopause-trained physician.
At Alloy, we’re passionate about empowering women with science-backed information and solutions for every stage of menopause.
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