GLP-1 Microdosing During Menopause: Is it Right for You?

Why You Must Consult a Menopause Specialist 

We get it. The idea of starting "low and slow" with GLP-1 medications feels intuitive, especially when you're navigating midlife weight gain and metabolic shifts that seem impossible to manage. Personal dosing (also known as microdosing) is when you use lower doses than the standard protocols approved by the FDA. Lately it has become an appealing option for women in menopause who want the weight-loss benefits without the side effects. And while gradual dose titration is a common clinical practice with FDA-approved medications, GLP-1 personal dosing in menopause is currently unapproved and the risks are unknown.

That’s why it is essential that you discuss yourpersonal treatment plan with your doctor at Alloy before starting any plan.

What’s the Connection Between GLP-1s and Menopausal Hormone Therapy (MHT)?

Recent research has shown that GLP-1s and MHT are a beneficial combination, with MHT actually amplifying the weight loss effects of certain GLP-1 medications. According to a study in the journal Menopause, women who were on MHT and semaglutide lost 30% more weight after 12 months than a control group of women who were on semaglutide but not hormone therapy. For midlife women navigating shifting hormones and stubborn weight, this combination can be a game-changer. 

How to Safely Use GLP-1 Medications for Metabolic Support

GLP-1 medications work in part by dramatically slowing gastric emptying: essentially, they make your stomach take longer to process food and medications. This adds to feelings of fullness and helps regulate blood sugar, but it can also reduce the absorption of oral medications that you are taking at the same time. That’s why it’s important for you to discuss all of your medications and concerns with your doctor at Alloy. 

If you're considering a GLP-1 for metabolic support during menopause, here's how to do it safely:

• Work with Experts: Consult exclusively with board-certified menopause experts who understand the nuances of midlife hormonal shifts.

• Focus on Resistance Training: Counteract muscle loss with regular strength exercises.

• Increase Your Protein Intake: Aim for 25–30 grams of protein per meal to protect metabolic health and muscle mass.

Stick with the Experts for GLP-1 Use

GLP-1 medications hold real promise for supporting metabolic health in midlife, but you should be fully informed about the risks. The key is to work with an experienced and knowledgeable doctor who knows your medical history, and who actively monitors your progress at every step. Additionally, you should integrate lifestyle changes that can protect your muscle mass and bone density.

Connect with a menopause-expert physician at Alloy to review your symptoms, discuss your metabolic risks, and explore treatment options that support your health in menopause.

Frequently Asked Questions

Is personal dosing GLP-1s FDA-approved for menopause?

No. While gradual dose titration is common, using GLP-1s at micro-doses specifically for menopause is currently unapproved and the long-term risks are unknown.

What side effects should I expect even at lower doses?

Even at lower doses, GLP-1s carry risks of gastrointestinal issues, including nausea, constipation, and general abdominal discomfort.

Why is protein intake important while taking GLP-1s?

GLP-1s can accelerate muscle loss. Because menopause already increases this risk due to declining estrogen, a high-protein diet (25-30g per meal) and resistance training are essential.