Prescription-Strength Skincare

Alloy's M4 skincare is the first estriol-powered formula clinically proven to rebuild collagen, restore elasticity, and visibly reduce wrinkles in just 12 weeks.

Starting at $30 per month.

Confirmed by Experts.

Felt by Real Women.

Results from three independent clinical studies.*

Monica Before & After

4.6

stars from 2k Trustpilot skin reviews

95%

felt smoother skin with M4 Body Treatment

88%

improved elasticity with M4 Face Cream

20%

more supple skin with M4 Eye Cream

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Featured in Oprah's O-wards

Menopause-Expert Doctors

Simple Intake Form

HSA and FSA Eligible

Transform Your Skin

Target fine lines, wrinkles, and signs of aging with prescription power

BEST SELLERM4 Face Cream Rx

M4 Face Cream Rx

Estriol

$150.00

NEWM4 Body Treatment Rx

M4 Body Treatment Rx

Estriol + Peptides

$195.00

M4 Eye Cream Rx

M4 Eye Cream Rx

Estriol + Peptides

$90.00

Oprah's O-wardsM4 Face Serum Rx

M4 Face Serum Rx

Estriol + Peptides + Hyaluronic Acid

$159.00

Tretinoin Face Cream Rx

Tretinoin Face Cream Rx

Tretinoin + Niacinamide

$90.00

Rosacea Face Cream Rx

Rosacea Face Cream Rx

Azelaic Acid + Metronidazole + Ivermectin

$99.00

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Estriol Ingredient

ESTRIOL: A TRUE GAME CHANGER

Estriol, a form of estrogen and the powerhouse ingredient in our M4 products, builds collagen, increases elasticity, and restores moisture.

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Targeted Treatments, Smart Savings

Get radiant, resilient skin with exclusive sets designed for visible results

$100 OFF M4 Head to Toe Set

Head to Toe Set

M4 Face Cream Rx, M4 Eye Cream Rx & M4 Body Treatment Rx

$335.00 $435.00

$100 OFF Glow & Go Bundle

Glow & Go Set

M4 Face Cream Rx, M4 Face Serum Rx, & M4 Eye Cream Rx

$299.00 $399.00

$30 OFFDaily Strength Duo Hero

Daily Strength Duo

M4 Face Cream Rx & M4 Eye Cream Rx

$210.00 $240

$30 OFFPower Pair Bundle

Power Pair

M4 Face Cream Rx & Tretinoin Face Cream Rx

$210.00 $240.00

The Reviews Are In, and They're Glowing

I have been using Alloy M4 and it’s unbelievable. Literally a miracle for my skin.

- Deborah C.

Obsessed with Alloy's M4 cream. My skin is ✨GLOWING✨

- Harprett T

This has been a game changer for my 52 year old skin. Wow!

- Laura T.

I have been using the M4 for 4 months now. I’m glowing! My face looks smoother and hydrated...So happy I found this magic in a bottle.

- Stacy M.

Precision Skincare in Every Step

Step 1

Treat the Eye Area

On clean skin, apply 1 pump of M4 Eye Cream Rx to each under eye and lid area

Step 2

Select Your M4 Base Treatment

AM routine or lighter hydration: Apply 2 pumps of  M4 Face Serum Rx

PM routine or deeper hydration: Apply 2 pumps of  M4 Face Cream Rx

Step 3

Lock in & Protect

AM: Follow with a moisturizer, SPF, and makeup as needed

PM: Apply a moisturizer or retinoid, like Alloy's Tretinoin Face Cream Rx

As directed by your provider

Step 4

Treat the Body

Apply 1 pump of M4 Body Treatment Rx to hands, arms, chest, legs above the knees, and stomach

Woman in Swimsuit

How to Get Alloy Skincare

Prescription skincare, made effortless.

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Frequently Asked Questions

Skin that feels like yours again

Your skin isn't aging, it's changing. Estriol gives it exactly what it's been missing.

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Disclosures

*2024 Study: Based on a 12-week randomized, double-blind, placebo-controlled clinical study (n=86) using Corneometer®, Cutometer®, and dermaspectrophotometer instrumental measurements, investigator clinical grading, and subject self-asses

2025 Study: Based on a 12-week clinical study (n=34) using Corneometer®, Moisturemeter EpiD, Cutometer®, and Antera 3D® instrumental measurements, expert visual and tactile grading, and self-assessment questionnaire.

2026 Study: Based on a 12-week clinical study (n=38) using Corneometer®, Moisturemeter EpiD, Cutometer®, and Antera 3D® instrumental measurements, expert visual and tactile grading, and self-assessment questionnaire.