M4 products help boost collagen, improve elasticity, & deeply hydrate the skin.  Discover science-backed skincare designed to target visible signs of aging - perfect for women going thru menopause. 

Menopause Skincare - M4 Creams | Anti-Aging for Women Over 50

Your Skin Has Never Looked Better

Alloy's M4 skincare is the first estriol-powered formula clinically proven to rebuild collagen, restore elasticity, and visibly reduce wrinkles in just 12 weeks.

Your skin deserves prescription-strength care

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Our Clinically Proven M4 Skincare - Your Best Skin

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Alloy became the first company to offer skincare with estriol—and independent tests showed significant, measurable results. In just 12 weeks, women using M4 creams saw visibly firmer, smoother, more radiant skin. 

See the changes co-founder Monica Molenaar saw with consistent use of M4 Eye Cream


Clinically Proven M4 Skincare 

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The complete M4 skincare system

Restore elasticity, hydrate deeply and build collagen—this powerful estriol-enriched face cream does it all

M4 Face Cream Rx

Estriol

Target fine lines and boost collagen with a lifting and renewing cream that smooths and firms delicate skin

M4 Eye Cream Rx

Estriol + Peptides

Smooth, firm and repair your skin with this deeply hydrating serum packed with collagen-boosting estriol

M4 Face Serum Rx

Estriol + Peptides + Hyaluronic Acid

Topical treatment compounded with niacinamide and aloe for acne, fine lines, hyperpigmentation, and discoloration

Tretinoin Face Cream Rx

Tretinoin + Niacinamide

Triple-action prescription rosacea cream clinically designed to target redness, inflammation, and sensitivity

Rosacea Face Cream Rx

Azelaic Acid + Metronidazole + Ivermectin

The complete M4 Skincare System

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Aging has never looked this good. Together, our M4 Face Cream Rx, M4 Face Serum Rx, and M4 Eye Cream Rx boost collagen production, restore hydration, improve elasticity, and support hormonal skin repair.

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Precision Skincare at Every Step of Your Routine

I have been using Alloy M4 and it’s unbelievable. Literally a __miracle for my skin.__

Deborah C.

Obsessed with Alloy's M4 cream. __My skin is ✨GLOWING✨__

Harprett T

This has been a __game changer__ for my 52 year old skin. Wow!

Laura T.

The Reviews Are In, And They're Glowing

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Skincare FAQ

In two independent clinical studies (one on M4 Face Cream Rx in 2024 and one on M4 Eye Cream Rx in 2025), results showed statistically significant improvements in hydration, elasticity, firmness, and overall skin health. Efficacy and safety results for both studies were verified by dermatology experts. 

__2024 Study to Assess the Facial Anti-Aging Efficacy of Topical Estriol and Estradiol__

Improvements seen in M4 Face Cream Rx with Estriol compared to placebo in 12 weeks include:
88% improvement in elasticity
70% improvement in hydration
68% improvement in overall skin health
57% improvement in skin texture

[Read the full clinical study](https://assets.ctfassets.net/md0kv0ejg0xf/4gaULAkbHbgNZtNMOgg1PI/91329de08abacf438fb83d99e756ee99/Alloy_M4_Report_063024.pdf)

__2025 Study to Evaluate the Efficacy of Estriol Eye Cream__

Improvements seen in M4 Eye Cream Rx in 12 weeks include:
Up to 25% wrinkle reduction
Up to 33% firmer looking skin*
Up to 40% more elasticity*
Up to 40% less crepiness on the eyelids*
Immediately boosted hydration by 23%**
*Based on Expert Assessment
**Based on Instrumentation 

[Read the full clinical study](https://downloads.ctfassets.net/md0kv0ejg0xf/73fv7ve0a2qmQlDBUqcn8A/5b8b1232ecac36e7d7d2d9f7c74cade4/2025_Estriol_Eye_Cream_Clinical_Study_Report.pdf)

What were the results of the clinical studies of M4 products?

M4 was made for women in perimenopause and menopause—the life stages when hormonal changes start to visibly affect the skin causing dryness, fine lines, and loss of radiance. Perimenopause typically begins in your 40s, though it can start as early as your mid-30s.

By age 50, women can lose up to 50% of their total collagen compared to peak levels. If you’re in perimenopause, M4 is a smart way to get ahead of the curve. Topical estriol, the star ingredient in our formulas, helps keep skin resilient, youthful, and balanced—before signs of aging deepen. And if you’re already in menopause, M4 is designed to restore what hormonal shifts have taken away: firmness, hydration, and that healthy glow.

When should I start using the M4 Skincare line?

During the first five years of menopause, women lose up to 30% of their dermal collagen due to declining estrogen levels, followed by an additional 2.5% loss each year thereafter. Alloy Co-Founder Monica Molenaar personally discovered the potential of topical estrogen when she began applying her prescription vaginal estrogen cream to her face three years ago. The results were promising, but the texture and sticky residue made it unsuitable for daily skincare.

Determined to create a product that combined the proven benefits of estrogen with a luxurious, skin-friendly formula, Monica embarked on a mission to develop something better. The result is the M4 Estriol Face Cream, a fragrance-free, dermatologist-tested formula that blends the power of estriol with deeply hydrating ingredients. It absorbs instantly, leaves no white or sticky residue, and delivers a smooth, nourishing experience designed specifically for the face.

What is M4 Estriol Face Cream?

Estriol is a less potent form of estrogen compared to estradiol but is very effective in addressing skin aging concerns. When applied topically, in low doses, it works locally on the skin rather than having systemic effects throughout the body. Early studies demonstrated that estriol is particularly effective in skincare, making it the ideal hero ingredient for our M4 Face Cream. Estrogen helps maintain skin thickness, moisture, and elasticity—which all decline sharply during perimenopause and menopause. And that’s exactly why we’ve now expanded the line of M4 skincare products with estriol and other clinically-proven active ingredients– to bring the same science-backed benefits of estriol to even more steps in your skincare routine.

Why do the M4 skincare products use estriol instead of estradiol?

__Yes__– and in many ways, even more so. Estriol visibly reduces wrinkles by up to __25% in just 12 weeks__. It also improves __firmness, elasticity, and hydration__, areas where tretinoin can fall short or take longer to deliver results. 
While tretinoin can be effective, it’s often harsh– especially on dry, thinning, or hormonally sensitive skin. Estriol, on the other hand, is gentle because it’s the same estrogen your body used to make naturally. Your skin has estrogen receptors in every cell, and when those go empty in midlife, skin function declines. By replenishing what’s missing, estriol helps restore skin health from the inside out.
Best of all, they don’t compete– they __complement__ each other. Use tretinoin to smooth and renew the surface plus reduce signs of sun damage, and estriol to rebuild and fortify deeper layers to make skin look and feel younger. Together, they offer a full-spectrum routine ideal for midlife skin.


Is estriol really as effective as tretinoin?

Our new M4 Face Serum and M4 Eye Cream were developed in response to real feedback from our community. The eye area is often where signs of aging show up first, and the face serum was designed to deliver smooth, layerable hydration that works seamlessly in a modern skincare routine. And our new M4 products add key anti-aging ingredients, like peptides and hyaluronic acid, to tackle multiple signs of aging.

Why were the eye cream and the face serum added to the line?

You can incorporate M4 products into your morning or nighttime skincare routine, and they’re compatible with your other skincare products.

Can I use M4 with my other favorite products? 

Yes– you can tailor your routine with any M4 product that fits your skin’s needs that day. Every formula is powered by estriol to boost collagen production, improve elasticity, and address hormonal aging – so you’ll still get the core benefits even if you use just one.

- M4 Face Cream Rx (original): A nourishing daily moisturizer with estriol plus barrier‑supporting lipids.
- M4 Face Serum Rx: A lighter, smoothing option with peptides and hyaluronic acid—perfect for morning use, or whenever you want extra firming and active ingredients under sunscreen or makeup.
- M4 Eye Cream Rx: A targeted eye treatment with 1 % estriol and peptides to hydrate, firm, and brighten the delicate eye area.

Choose whichever product (or combination of face + eye) makes sense for you. Let your daily concerns and routine guide you.

Can I use all three M4 products?

Alloy’s 2025 clinical study was conducted by Validated Claim Support, which is a privately held, independent and unbiased Clinical Testing Laboratory in Teaneck, NJ. Validated Claim Support specializes in clinical studies for skincare, haircare, and medical devices and is a  FDA Registered and Good Clinical Practice (GCP) laboratory. Our M4 Smooth & Firm Rx Priming Serum contains 0.3% estriol—the same concentration of active ingredient as our M4 Face Cream. While the formulas differ in texture and delivery system, the clinical results from M4 Face Cream are applicable, since the active is identical.

Read the [2024](https://assets.ctfassets.net/md0kv0ejg0xf/4gaULAkbHbgNZtNMOgg1PI/91329de08abacf438fb83d99e756ee99/Alloy_M4_Report_063024.pdf "2023 M4 Estriol Face Cream Study Report") and [2025](https://downloads.ctfassets.net/md0kv0ejg0xf/73fv7ve0a2qmQlDBUqcn8A/5b8b1232ecac36e7d7d2d9f7c74cade4/2025_Estriol_Eye_Cream_Clinical_Study_Report.pdf "2025 M4 Estriol Eye Cream Study Report") studies.

Who conducted the most recent study?

No, none of the M4 products (M4 Face Cream Rx, M4 Face Serum Rx, and M4 Eye Cream Rx) increase estrogen levels. They are non-systemic and safe with MHT and vaginal estrogen.

Do the M4 products increase estrogen levels?

Frequently Asked Questions

Powerfully effective, clinician-formulated M4 skincare featuring estriol to restore moisture, increase elasticity, and reduce fine lines. Shop M4 Face Cream Rx, M4 Eye Cream Rx, M4 Face Serum Rx, and targeted prescription treatments.

M4 Skincare Products | Renew, Rebuild, and Restore Skin

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Estrogen-powered anti-aging cream that hydrates, restores elasticity, and rebuilds collagen. Clinically proven to improve firmness, bounce, and texture in 12 weeks—with up to 88% improvement in elasticity. Gentle and non-comedogenic.

Our prescription-only eye cream combines 1% estriol with wrinkle-fighting peptides to brighten, tighten, and transform the delicate eye area. The first of its kind–formulated by Alloy to deliver unmatched results for combatting the signs of aging.

M4 Face Serum Rx with Estriol, Peptides, and Hyaluronic Acid is a comprehensive anti-aging treatment that targets fine lines, dryness, and loss of firmness. A powerful blend designed to hydrate, smooth, and visibly renew skin as it ages.

Tretinoin is a topical treatment compounded with niacinamide and aloe for acne, fine lines, hyperpigmentation, and discoloration.

A prescription cream that calms inflamed, sensitive skin and visibly reduces redness. It helps restore the skin barrier and decreases pustules associated with rosacea.