The First (and Only) Eye Cream with Estriol

At Alloy, we’re always tuned in, to our customers and to what our own skin is telling us. After seeing the powerful results of our face cream, we knew there was an opportunity to do even more, especially for the delicate eye area, often the first place signs of aging appear. That’s why we created our new  M4 Eye Cream Rx, a groundbreaking formula powered by prescription-strength estriol, designed specifically to support thin, crepe-y, and wrinkle-prone skin around the eyes. This first-of-its-kind innovation is exclusively available from Alloy, because when it comes to caring for your skin, we never stop advancing.

How It Started 

It’s an undeniable fact: as we age, estrogen declines, and with it, collagen levels. Collagen is the protein that provides structure to your muscles, bones, connective tissue, and skin. In the first five years of menopause alone, up to 30% of dermal collagen is lost, with another 2.1% lost every year after. The solution? Stimulate collagen production by replenishing estrogen, which is where our M4 skincare comes in. 

In 2023, Alloy was the first company to include topical estriol in skincare: our M4 Face Cream Rx, and it has been an incredible success story. The results of a 2024 independent clinical study showed that in just 12 weeks, significant improvements seen in M4 Face Cream Rx compared to a placebo, include:

• 88% improvement in elasticity and plumpness 

• 70% improvement in hydration

• 68% improvement in overall skin health

• 57% improvement in skin texture

Read the full clinical study

Onto the Next Phase

Building on the breakthrough success of M4 Face Cream Rx, we’re taking the next step in targeted skincare innovation. Alloy’s M4 Eye Cream Rx is a true first. A uniquely formulated cream with a full 1% estriol designed to boost cell turnover, support collagen production, deeply hydrate, and enhance elasticity. The result? Brighter, tighter, visibly transformed skin around the eyes.

Other anti-aging ingredients include:

• Palmitoyl Pentapeptide-4: A peptide that reduces fine lines and wrinkles, and smooths skin.

• Acetyl Hexapeptide-8: A peptide that helps prevent expression lines and supports firmness.

• Glycerin: A powerful humectant that attracts and retains moisture in the skin, helping to keep it hydrated, smooth, and plump. It supports the skin barrier and enhances overall skin health.

• Olea Europaea (Olive) Fruit Oil: A nutrient-rich emollient derived from olives, known for its high content of fatty acids and antioxidants. It helps moisturize, soften, and protect the skin while supporting barrier function.

• Vitamin E Acetate: A stabilized form of vitamin E that protects against environmental damage and supports skin resilience.

And again, the results have been fantastic! A 2025 independent clinical study showed that after 12 weeks, significant improvements* with M4 Eye Cream Rx include:

• Up to 25% wrinkle reduction*

• Up to 33% firmer looking skin*

• Up to 40% more elasticity*

• Up to 40% less crepiness on the eyelids*

• 23% immediate boost in hydration**

*Based on Expert Assessment **Based on Instrumentation 

As part of the 2025 clinical study, we also asked the women who tested our M4 Eye Cream Rx how it worked for them, and the results of their self assessments at 12 weeks speak for themselves:

• 76% said their eye area looked less tired and fatigued

• 76% saw smoother skin and a visible softening of wrinkles and crow’s feet

• 79% said their skin looked firmer

• 74% noticed a brighter, more even skin tone

Read the Full Clinical Study

The Net-Net 

M4 Eye Cream Rx with Estriol and Peptides delivers immediate and long-lasting hydration, and measurably firmer, bouncier-looking skin with fewer fine lines and wrinkles.  

• Brightens and hydrates delicate orbital eye area

• Smooths crow’s feet and signs of fatigue

• Fragrance-free

• Proven to be non-comedogenic, non-irritating, and well-tolerated, even by sensitive skin

• Can be used with or without MHT because it does not impact blood estrogen levels

Ready to try it? Shop now