The Science
Behind Putting Estrogen On Your Face

Here's why our revolutionary face cream works

Did You Know...

Woman looking into a bathroom mirror with her hands on her face

Up to 30% of dermal collagen is lost during the first 5 years of menopause.

It decreases by an additional 2.1% every year after that.

Studies have shown that estrogen deficiency is associated with a dramatic reduction in skin health and wellness.¹

illustrated macro view of young skin
Young Skin
illustrated macro view of aged skin
Aged Skin

That's Where Estriol Comes In

Alloy branded bag on a bathroom shelf

The solution to losing estrogen is replenishing it.

And the benefits of MHT on skin aging are well-documented.² Research has shown that topical estriol can help maintain skin health by increasing collagen production, retaining and restoring skin moisture, increasing skin firmness and elasticity, and decreasing pore size and wrinkle depth.

woman subtly smirking while looking at her face in a bathroom mirror
Alloy branded bag on a bathroom shelfwoman subtly smirking while looking at her face in a bathroom mirror

In one study³, after 6 months of topical estrogen use, skin elasticity and firmness had improved and wrinkle depth and pore size had decreased by 61-100%.

Is it safe?

YES. For everyone. Even if you're not a candidate for MHT, you can use estriol face cream. Studies have confirmed that like local, topical vaginal estradiol, topical facial estriol does not increase systemic serum levels of estrogen. There are no hormonal side effects.⁴

Can I combine M4 with my MHT?

YES. Because studies have confirmed that local, topical vaginal estradiol, does not increase systemic serum levels of estrogen, you can use it alone or with other MHT.

What Else is In M4?

Glycerin: It's an excellent humectant. It attracts moisture and locks it into the top layer of your skin, leaving it hydrated.

Vitamin E: Stops skin from losing moisture, protects cells from UV damage, and softens skin.