What is the difference between tirzepatide and semaglutide for weight loss?
The biggest difference is how they work. Semaglutide is a GLP-1 medication, while tirzepatide acts on both GLP-1 and GIP, two hormone pathways involved in appetite, digestion, and blood sugar. Here at Alloy, we describe tirzepatide as a dual-action option, and that dual effect may lead to greater weight loss for some people.
In the product information we share, semaglutide options like Wegovy average about 15% body weight loss in 12 months. Tirzepatide options like Zepbound KwikPen are described at about 15 to 20% in 12 months, and one study cited in our content showed up to 21% over 72 weeks. Both are commonly used as weekly injections, but semaglutide is also available here at Alloy as a daily pill, Wegovy Pill, while oral tirzepatide is still being studied.
Wegovy® Pen
Starting at $199 /month $499
The side effects overlap a lot. With both, the most common issues are stomach related, like nausea, vomiting, diarrhea, constipation, and bloating, and these often improve as your body adjusts. In real life, the better fit usually depends on your goals, medical history, side effect tolerance, and whether you prefer a weekly shot or, in semaglutide’s case, a daily pill. You can also read more about compounded tirzepatide if you want to compare the tirzepatide options we offer here at Alloy.
Compounded Tirzepatide
Starting at $100 /month
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