How did weight-loss outcomes differ when evaluating clinically meaningful thresholds like 5%, 10%, 15%, and 20% of total body weight?
When researchers looked at clinically meaningful weight loss thresholds of 5%, 10%, 15%, and 20% of total body weight, the differences were clear.
In the study comparing women on GLP-1 medications alone versus those using GLP-1s plus menopausal hormone therapy, the group using both treatments consistently had higher success rates at every threshold:
A greater percentage achieved at least 5% weight loss
More reached 10%
More reached 15%
And more achieved 20% total body weight loss
This pattern held across multiple time points, including 3, 6, 9, and 12 months. In other words, women using GLP-1s together with hormone therapy were more likely to reach higher levels of total body weight reduction.
You can see the breakdown visually in this section of our video: GLP-1s + MHT: A Power Combo for Weight Loss? - Study Results: Weight Loss Comparison
At Alloy, this is why we offer a holistic Weight Care program that includes both GLP-1 medications and MHT when appropriate. The combination has been shown to produce about 30% greater weight loss after 12 months compared to GLP-1 use alone. If you’d like to learn more about how we approach this combination, you can explore our program here: Start Your Weight Care Journey with Alloy
This answer was created using the following resources: