Does topical estriol cream lead to systemic hormone absorption?

Topical estriol creams, like the ones we use here at Alloy, stay local to the skin and do not raise systemic estrogen levels. This has been shown repeatedly in studies of facial estriol and in decades of data on vaginal estradiol, which is actually a much stronger form of estrogen.

Dr. Ellen Gendler and Dr. Corinne Menn talk about this quite a bit. In testing, serum estrogen levels stay unchanged, and absorption becomes even less likely as the skin thickens and gets healthier with use. If you want to hear them explain it directly, the Topical Estrogen Safety chapter from our YouTube event might be helpful because they walk through exactly why the cream stays localWatch the chapter.

For more detail on our estriol face cream, you can visit the M4 Face Cream page:M4 Face Cream Rx.

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So the short answer is yes, you get the skin benefits without systemic hormone exposure.

This answer was created using the following resources:

• A New Approach to Aging with Alloy - Topical Estrogen Safety

• Topical Estrogen's Role in Healthy, Radiant Skin | Dr. Ellen Gendler & Dr. Corinne Menn - Research & Safety of Topical Estrogen

• Skin Deep with Dr. Menn: Let's Talk Skincare & Estrogen | Dr. Corinne Menn - Who Can Use Topical Estrogen

• When’s the Best Time to Start Hormone Therapy? | Dr. Sharon Malone - Systemic vs. Topical Estrogen

• Why Estriol + Tretinoin Make a Great Team - Topical Estrogen Effects

• What Menopause Does to Your Skin & How to Fix It | Dr. Corinne Menn - Estrogen Therapy for Skin

• From the Inside Out: Skin, Hair & Hormones | Dr. Deepti Gandhi - Topical Estriol for Skin

• The Science Behind Putting Estrogen On Your Face

• Topical Estrogen: Tips from Dr. Ellen Gendler

• Estradiol Cream or Patches? Find the Best Option for You

• What Is Estradiol?