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Estradiol Vaginal Cream

FDA-approved, plant-based, bio-identical hormone treatment for the alleviation of genitourinary syndrome of menopause (vaginal dryness, itching, burning, painful sex, incontinence, and frequent UTIs)

$119.97 for a 3-month supply

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is it for?

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Who is it for?

For any woman experiencing genitourinary symptoms, including vaginal dryness, itching, burning, incontinence, painful sex, and frequent UTIs. The vaginal cream contains a small amount of estradiol (0.01%), one of three kinds of estrogen your body makes naturally. The dose is low enough that it is only absorbed in the tissue it is applied to, and does not raise blood levels of estrogen. This means it's safe for everyone, including breast cancer survivors.

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What is it?

A 3-month supply of non-systemic estradiol vaginal cream (0.01%) along with an applicator. Note: The whole 3-month supply comes in one tube!

When used consistently, estradiol vaginal cream can reverse tissue changes such as thinning and altered pH due to the genitourinary syndrome of menopause. Unlike a topical lubricant, estradiol cream addresses the root cause of these issues. Because you are actually restoring the vaginal, vulvar and urethral tissues, you will start feeling better gradually. The timeline for maximum results is 4-12 weeks.

How to use it

The official recommended dosage is 1 gram every other day. That's approximately 15 grams in a month, and the tube contains 42.5 grams, so a tube should last you the whole 3 months! A gram is equivalent to a pea-sized amount.

If you are using the cream internally, it is best applied with the applicator, which helps you measure out the correct dosage and get the cream far up the vaginal canal to reach the bladder and urethra. If you'd rather not use the applicator, your index finger can work too.

The cream can also be used externally. Use it on the vulva or anywhere you feel discomfort. Just use your fingers and remember to rub the cream in completely.

Regardless of the application, it is important to stick with it. Once you have maximum improvement you may find you need to use it less, but it is recommended you use it at least 2-3 times per week to maintain results.

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Vaginal Cream?

  1. Complete Alloy's online assessment in 1 minute.
  2. A menopause-trained doctor reviews your information and writes your prescription.
  3. Your prescription is shipped right to your door.
  4. Free and unlimited follow-up with your doctor.

Related Research

Management of genitourinary syndrome of menopause in women with or at high risk for breast cancer: consensus recommendations from The North American Menopause Society and The International Society for the Study of Women's Sexual Health. Faubion SS, Larkin LC, Stuenkel CA, et al. Menopause 2018;25:596-608 https://pubmed.ncbi.nlm.nih.gov/29762200/

American College of Obstetricians and Gynecologists' Committee on Gynecologic Practice Farrell R. ACOG Committee Opinion No. 659 summary: the use of vaginal estrogen in women with a history of estrogen-dependent breast cancer. Obstet Gynecol 2016;127:618-619 https://pubmed.ncbi.nlm.nih.gov/26901334/

Genitourniary Syndrome of Menopause: The Unmet Need, Susan Kellogg Spadt, PhD, CRNP, IF, CSC,1 and Lisa C Larkin, MD, FACP, NCMP, IF, Released October 21, 2020 https://www.menopause.org/docs/default-source/professional/nams-practice-pearl-gsm.pdf

NAMS Practice Pearl, “Restoring Vaginal Function in Postmenopausal Women with Genitourinary Syndrome of Menopause” June 15, 2017 https://www.menopause.org/docs/default-source/professional/nams-practice-pearl-restoring-vaginal-function.pdf

Breast cancer, endometrial cancer, and cardiovascular events in participants who used vaginal estrogen in the Women's Health Initiative Observational Study. Crandall CJ, Hovey KM, Andrews CA, et al.Menopause 2018;25:11-20 https://pubmed.ncbi.nlm.nih.gov/28816933/

Safety of vaginal estrogens: a systematic review. Menopause. Crandall CJ, Diamant A, Santoro N.2020 Mar;27(3):339-360. https://pubmed.ncbi.nlm.nih.gov/31913230/

Local estrogen therapy and risk of breast cancer recurrence among hormone-treated patients: a nested case-control study. Breast Cancer Res Treat Le Ray I, Dell'Aniello S, Bonnetain F, Azoulay L, Suissa S. 2012;135:603-609 https://pubmed.ncbi.nlm.nih.gov/22903687/

Managing Genitourinary Syndrome of Menopause in Breast Cancer Survivors Receiving Endocrine Therapy.Sussman TA, Kruse ML, Thacker HL, Abraham J. J Oncol Pract. 2019 Jul;15(7):363-370 https://ascopubs.org/doi/pdf/10.1200/JOP.18.00710?role=tab