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M4 Face Serum RxM4 Eye Cream RxTretinoin Face Cream Rx

Precision Rx Trio

$279.00

1 Bottle M4 Face Serum Rx, 1 Bottle M4 Eye Cream Rx & 1 Bottle Tretinoin Face Cream Rx

$339 Value

Repair, renew, and restore mature skin with this next-generation collection. M4 Face Serum Rx, M4 Eye Cream Rx, and Tretinoin Face Cream Rx work in tandem to target dryness, dullness, and fine lines for visibly smoother, more youthful-looking skin.

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SAVE $60 WITH THE Precision Rx Trio

Our powerhouse skin health trio: M4 Face Serum Rx, M4 Eye Cream Rx, and Tretinoin Face Cream Rx.

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The results are in on M4 Eye Cream Rx

In a 2025 independent clinical study, statistically significant improvements* seen in M4 Eye Cream Rx in a 12-week study include:

25%

improvement in wrinkle reduction

33%

improvement in firmness

40%

improvement in more elasticity

40%

improvement in crepiness on eyelids

M4 Eye Cream Rx can be used with or without MHT because it does not impact blood estrogen levels. *Based on expert assessment

Read the full clinical study

Learn more about the Precision Rx Trio

What is it: Our Precision Rx Trio 3 features three products with powerful anti-aging benefits: M4 Face Serum Rx with Estriol, Peptides + Hyaluronic Acid, M4 Eye Cream Rx with Estriol + Peptides, and Tretinoin Face Cream Rx. The estriol in our M4 line replenishes what skin has lost with age to help it look smoother, bouncier, and more vibrant. And Tretinoin, a retinoid derived from vitamin A, helps speed up cell turnover to give skin a more youthful look and feel.

Who is it for: Women looking to fight signs of aging due to estrogen deficiency.

What am I getting: 1 bottle (45 grams) of M4 Face Serum Rx, 1 bottle (30 grams) of M4 Eye Cream Rx, & 1 bottle containing 30grams of Tretinoin Face Cream Rx. We offer three different strengths of Tretinoin to address individual skin needs. This set contains a 3-month supply of each.

How to get it: Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you.

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Estriol Is a Game-changer

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Real Women Love It

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How Tretinoin Works

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Did you know?

Skin elasticity can decline by as much as 20% in the first two years post-menopause.

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What is Estriol?

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What is Tretinoin?

How it Works

Go from experiencing symptoms to finding solutions in no time.

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Frequently asked questions

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The Alloy Promise

Alloy believes that every woman deserves accurate, up-to-date information and the agency to make her own decisions about her health based on facts, not fear.

All of our board-certified physicians follow ACOG and The Menopause Society guidelines and prescribe only FDA-approved, generic medications for the treatment of menopausal symptoms. The safety of our products is our top priority.

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The Alloy Promise