
Precision Rx Trio
$279.00
1 Bottle M4 Face Serum Rx, 1 Bottle M4 Eye Cream Rx & 1 Bottle Tretinoin Face Cream Rx
Repair, renew, and restore mature skin with this next-generation collection. M4 Face Serum Rx, M4 Eye Cream Rx, and Tretinoin Face Cream Rx work in tandem to target dryness, dullness, and fine lines for visibly smoother, more youthful-looking skin.
Free shipping
Unlimited messaging with a menopause-trained doctor
SAVE $60 WITH THE Precision Rx Trio
Our powerhouse skin health trio: M4 Face Serum Rx, M4 Eye Cream Rx, and Tretinoin Face Cream Rx.

The results are in on M4 Eye Cream Rx
In a 2025 independent clinical study, statistically significant improvements* seen in M4 Eye Cream Rx in a 12-week study include:
improvement in wrinkle reduction
improvement in firmness
improvement in more elasticity
improvement in crepiness on eyelids
M4 Eye Cream Rx can be used with or without MHT because it does not impact blood estrogen levels. *Based on expert assessment
Learn more about the Precision Rx Trio
What is it: Our Precision Rx Trio 3 features three products with powerful anti-aging benefits: M4 Face Serum Rx with Estriol, Peptides + Hyaluronic Acid, M4 Eye Cream Rx with Estriol + Peptides, and Tretinoin Face Cream Rx. The estriol in our M4 line replenishes what skin has lost with age to help it look smoother, bouncier, and more vibrant. And Tretinoin, a retinoid derived from vitamin A, helps speed up cell turnover to give skin a more youthful look and feel.
Who is it for: Women looking to fight signs of aging due to estrogen deficiency.
What am I getting: 1 bottle (45 grams) of M4 Face Serum Rx, 1 bottle (30 grams) of M4 Eye Cream Rx, & 1 bottle containing 30grams of Tretinoin Face Cream Rx. We offer three different strengths of Tretinoin to address individual skin needs. This set contains a 3-month supply of each.
How to get it: Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you.
Estriol Is a Game-changer
Real Women Love It
How Tretinoin Works

Did you know?
Skin elasticity can decline by as much as 20% in the first two years post-menopause.

What is Estriol?

What is Tretinoin?
The Alloy Promise
Alloy believes that every woman deserves accurate, up-to-date information and the agency to make her own decisions about her health based on facts, not fear.
All of our board-certified physicians follow ACOG and The Menopause Society guidelines and prescribe only FDA-approved, generic medications for the treatment of menopausal symptoms. The safety of our products is our top priority.