
Power Pair Set
$210.00
1 bottle Tretinoin Face Cream Rx & 1 bottle M4 Face Cream Rx
Together, this pair delivers a full-spectrum routine ideal for midlife skin. M4 Face Cream Rx with Estriol and Vitamin E boosts collagen production, restores hydration, and improves elasticity. Tretinoin Face Cream Rx with Niacinamide and Aloe gives skin a more youthful look and feel.
Free shipping
Unlimited messaging with a menopause-trained doctor
SAVE $30 WITH THE POWER PAIR SET
Pair M4 Face Cream Rx with Tretinoin Face Cream Rx to target aging from the inside out—smarter skincare, better results, and built-in savings.

M4 is clinically proven to be powerfully effective
In an independent clinical study, statistically significant improvements seen in M4 Face Cream Rx compared to placebo in just 12 weeks include:
improvement in elasticity
improvement in hydration
improvement in overall skin health
improvement in skin texture
M4 Face Cream Rx can be used with or without MHT because it does not impact blood estrogen levels.
Learn more about the Power Pair Set
What is it: The Power Pair Set includes M4 Face Cream Rx with Estriol and Vitamin E and Tretinoin Face Cream Rx with Niacinamide and Aloe. Use Tretinoin to smooth and renew the surface plus reduce signs of sun damage, and estriol to rebuild and fortify deeper layers to make skin look and feel younger.
Who is it for: Women looking to fight signs of aging due to estrogen deficiency.
What am I getting: 1 bottle (45 grams) of M4 Face Cream Rx & 1 bottle (30 grams) of Tretinoin Face Cream Rx. Alloy offers three different strengths of Tretinoin to address individual skin needs. This set contains a 3-month supply of each.
How to get it: Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you.
Estriol Is a Game-changer
Real Customers Love It
Powerful Ingredients

Did you know?
Up to 30% of dermal collagen is lost in the first 5 years of menopause—with another 2.1% lost every year after.

What is Estriol?

What is Tretinoin?
Frequently asked questions
The Alloy Promise
Alloy believes that every woman deserves accurate, up-to-date information and the agency to make her own decisions about her health based on facts, not fear.
All of our board-certified physicians follow ACOG and The Menopause Society guidelines and prescribe only FDA-approved, generic medications for the treatment of menopausal symptoms. The safety of our products is our top priority.