Winner: 2025 Oprah O-wards Best Estrogen Moisturizer
M4® Face Cream Rx
$150.00
3-month supply
EstriolPlant Based Bioidentical
Estrogen-powered anti-aging cream that hydrates, restores elasticity, and rebuilds collagen. Clinically proven to improve firmness, bounce, and texture in 12 weeks—with up to 88% improvement in elasticity. Gentle and non-comedogenic.
Includes $0 unlimited doctor access
Delivered to your door for free
HSA/FSA Eligible
M4 is clinically proven to be powerfully effective
In an independent clinical study, statistically significant improvements seen in M4 Face Cream Rx compared to placebo in just 12 weeks include:
Learn more about M4 Face Cream Rx
What is it: A clinically proven, fragrance-free, prescription, estrogen-based face cream we created specifically for perimenopausal and menopausal women. The combination of increased hydration and collagen stimulation is a major innovation that helps address and prevent signs of aging.
Who is it for: M4 was made for women in perimenopause and menopause—the life stages when hormonal changes start to visibly affect the skin, causing dryness, fine lines, and loss of radiance.
What am I getting: 1 bottle containing (3-month supply) of M4 Face Cream Rx.
How to get it: Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you.
Bounce Back with M4
Real Customers Love It
See Results in as Little as 12 Weeks
Works with your routine
BRAVO @MYALLOY
"I'm 56 and have been using these products for a few months now and am blown away. My skin is soft and hydrated. Big fan. "
- Susie via Instagram
THE M4 DIFFERENCE
The Original Estriol-Based Prescription Skincare Collection
Alloy was the first to harness the power of estriol to combat the effects of hormone loss in your skin.
Created by experts, trusted by doctors, and loved by women everywhere, the M4 collection is designed to work together. Each product is clinically proven to rebuild collagen, restore moisture, increase elasticity, and reduce wrinkles where you need it most.
M4 Active Ingredient: Estriol
Estriol, a form of estrogen and the powerhouse ingredient in our M4 products, builds collagen, increases elasticity, and restores moisture.
Frequently asked questions
The Alloy Promise
At Alloy Health, we believe every woman deserves thoughtful, evidence-based care, and the information she needs to make confident decisions about her health based on facts, not fear.
Our board-certified physicians follow guidelines from leading medical organizations including ACOG and The Menopause Society and recommend treatments tailored to each patient.
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