
M4 Core Routine Kit
$270.00
1 Bottle M4 Face Cream Rx, 1 Bottle M4 Eye Cream Rx & 1 Bottle Tretinoin Face Cream Rx
This potent trio includes M4 Face Cream Rx, M4 Eye Cream Rx, and Tretinoin Face Cream Rx. The M4 products work below the surface to deeply hydrate skin, boost collagen production, and improve elasticity. Tretinoin, a retinoid derived from vitamin A, helps accelerate cell turnover to give skin a more youthful look and feel.
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Unlimited messaging with a menopause-trained doctor
SAVE $60 WITH THE M4 CORE ROUTINE KIT
The ultimate skin longevity team: M4 Face Cream Rx, M4 Eye Cream Rx, and Tretinoin Face Cream Rx.

The results are in on M4 Eye Cream Rx
In a 2025 independent clinical study, statistically significant improvements* seen in M4 Eye Cream Rx in a 12-week study include:
improvement in wrinkle reduction
improvement in firmness
improvement in more elasticity
improvement in crepiness on eyelids
M4 Eye Cream Rx can be used with or without MHT because it does not impact blood estrogen levels. *Based on expert assessment
Learn more about the M4 Core Routine Kit
What is it: This team of skincare products is our most intensive anti-aging combination with science-backed results. It includes our M4 Face Cream Rx with Estriol and Vitamin E, M4 Eye Cream Rx with Estriol + Peptides, and Tretinoin Face Cream Rx. When used together, all three work to significantly improve (and even reverse) signs of hormonal aging.
Who is it for: Women looking to fight signs of aging due to estrogen deficiency.
What am I getting: 1 bottle (45 grams) of M4 Face Cream Rx, 1 bottle (30 grams) of M4 Eye Cream Rx, & 1 bottle (30 grams) of Tretinoin Face Cream Rx. We offer three different strengths of Tretinoin to address individual skin needs. This set contains a 3-month supply of each.
How to get it: Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you.
Estriol Is a Game-changer
Real Customers Love It
How Tretinoin Works

Did you know?
By age 50, women can lose up to 50% of their total collagen compared to peak levels.

What is Estriol?

What is Tretinoin?
The Alloy Promise
Alloy believes that every woman deserves accurate, up-to-date information and the agency to make her own decisions about her health based on facts, not fear.
All of our board-certified physicians follow ACOG and The Menopause Society guidelines and prescribe only FDA-approved, generic medications for the treatment of menopausal symptoms. The safety of our products is our top priority.