M4 is clinically proven safe and effective

In an independent clinical study, statistically significant improvements seen in M4 Cream compared to placebo in just 12 weeks include:

arrow up88%
improvement in elasticity
arrow up68%
improvement in skin health
arrow up70%
improvement in hydration
arrow up57%
improvement in skin texture

M4 can be used with or without MHT because it does not impact blood estrogen levels. No changes in serum estriol and estradiol levels.

Read the full clinical study
A note about compounded products
m4 product in use

Did you know?

Up to 30%
of dermal collagen is lost during the
first 5 years of menopause
and decreases by an additional 2.1% every year after

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m4 product in use

is it for?

m4 product photo

Who is it for?

For any woman—really, any woman—looking to reverse the effects of estrogen-deficiency in the skin due to menopause, perimenopause, or just aging (loss of collagen, decreased elasticity and dryness). M4 works alone or alongside your current menopause treatment plan.

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How to use it

Adding M4 once, either to your morning or nighttime skincare routine, is easy. It's safe to use with your other skincare solutions.

During your normal morning skincare routine, apply a pump of M4 to the face and neck when after serums (if you use them). Follow it up with moisturizer, and always complete your morning routine with SPF!

If you're using M4 as part of your nighttime routine, apply a pump of M4 after serums (if you use them), followed by nighttime moisturizers and any retinols (if you use them).

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m4 product photo
woman relaxing

Ready to get

  1. Complete Alloy's online assessment in 1 minute.
  2. A menopause-trained doctor reviews your information and writes your prescription.
  3. Your prescription is shipped right to your door.
  4. Free and unlimited follow-up with your doctor.

Related Research

Lephart ED, Naftolin F. Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin. Dermatol Ther (Heidelb). 2021 Feb;11(1):53-69. doi: 10.1007/s13555-020-00468-7. Epub 2020 Nov 26. PMID: 33242128; PMCID: PMC7859014.

Rzepecki AK, Murase JE, Juran R, Fabi SG, McLellan BN. Estrogen-deficient skin: The role of topical therapy. Int J Womens Dermatol. 2019 Mar 15;5(2):85-90. doi: 10.1016/j.ijwd.2019.01.001. PMID: 30997378; PMCID: PMC6451761.