rx iconm4 product



A restorative & custom-blended estriol face cream to address signs of aging

$149.97 for a 3-month supply (1.52 oz /45ml)

How it works

  • checkmarkIncreases collagen production
  • checkmarkRetains and restores skin moisture
  • checkmarkIncreases skin firmness
  • checkmarkDecreases pore size
  • checkmarkDecreases wrinkle depth
  • checkmarkIncreases skin elasticity
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A note about compounded products
m4 product in use

Did you know?

Up to 30%
of dermal collagen is lost during the
first 5 years of menopause
and decreases by an additional 2.1% every year after

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m4 product in use

is it for?

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Who is it for?

For any woman—really, any woman—looking to reverse the effects of estrogen-deficiency in the skin due to menopause, perimenopause, or just aging (loss of collagen, decreased elasticity and moisture, and appearance of wrinkles). M4 works alone or alongside your current menopause treatment plan.

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How to use it

Adding M4 once, either to your morning or nighttime skincare routine, is easy. It’s safe to use with your other skincare solutions.

During your normal morning skincare routine, apply a pump of M4 to the face and neck when after serums (if you use them). Follow it up with moisturizer, and always complete your morning routine with SPF!

If you’re using M4 as part of your nighttime routine, apply a pump of M4 after serums (if you use them), followed by nighttime moisturizers and any retinols (if you use them).

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Ready to get

  1. Complete Alloy's online assessment in 1 minute.
  2. A menopause-trained doctor reviews your information and writes your prescription.
  3. Your prescription is shipped right to your door.
  4. Free and unlimited follow-up with your doctor.

Related research:

  1. Lephart ED, Naftolin F. Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin. Dermatol Ther (Heidelb). 2021 Feb;11(1):53-69. doi: 10.1007/s13555-020-00468-7. Epub 2020 Nov 26. PMID: 33242128; PMCID: PMC7859014.

  2. Rzepecki AK, Murase JE, Juran R, Fabi SG, McLellan BN. Estrogen-deficient skin: The role of topical therapy. Int J Womens Dermatol. 2019 Mar 15;5(2):85-90. doi: 10.1016/j.ijwd.2019.01.001. PMID: 30997378; PMCID: PMC6451761.