What level of weight loss is commonly seen with semaglutide, and how might combining it with menopausal hormone therapy affect expectations?

What weight loss is commonly seen with semaglutide?

Here at Alloy, we typically talk about semaglutide (Wegovy®) expectations in terms of percent of starting body weight. A common average is about 15% of body weight lost over 12 months. (You’ll usually notice appetite changes first, then steadier loss over the following months.) You can see that on our Wegovy® page

Wegovy®

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(30 days of treatment)

Average weight loss is 15% of body weight in 12 months

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How adding menopausal hormone therapy (MHT) might change expectations

MHT isn’t considered a weight-loss medication on its own, but it can help with fat distribution and with menopause symptoms like hot flashes and sleep disruption, which can make weight management harder.

When MHT is combined with semaglutide, an early study in Menopause found that women on both MHT and semaglutide lost about 30% more weight at 12 months than women on semaglutide who weren’t using hormone therapy. So if you’re someone who’s a good candidate for MHT, adding it could mean your results on semaglutide may be better than you’d expect from semaglutide alone. More details (and the study citation) are GLP-1 and Menopausal Hormone Therapy: A Powerful Combination

A quick note on safety and doing them together

At Alloy, we also note there are no contraindications to using GLP-1s and MHT at the same time, and some early data suggests benefits to the combo: Can I take GLP-1 medication with Menopausal Hormone Therapy (MHT)?

If you want to explore whether you qualify for Alloy’s Weight Care program (with GLP-1s, and support around side effects and dosing), you can start here: Alloy Weight Care program

If you’d rather watch, Dr. Alexandra Sowa talks about average weight loss on semaglutide (and why results vary person to person) in this chapter: What’s Really Behind Menopausal Weight Gain—and How to Treat It | Dr. Alexandra Sowa - Average Weight Loss and Hyperresponders

This answer was created using the following resources:

• What’s Really Behind Menopausal Weight Gain—and How to Treat It | Dr. Alexandra Sowa - Average Weight Loss and Hyperresponders

• GLP-1 and Menopausal Hormone Therapy: A Powerful Combination

• How Long Does It Take For Semaglutide to Work?

• Are GLP-1 Weight Loss Medications Safe? | GLP-1 Side Effects