Meet your simple,
science-backed
skincare routine
Glow from the inside out!
The perfect one-two combo for healthy, radiant skin
M4 Estriol Face Cream
149.97 (3 month supply)
Our fragrance-free, custom-blended estriol moisturizer which works to replenish estrogen, increase collagen production, and address signs of aging.
How to use:
Use M4 in the morning or at night after serums, before moisturizers.
Tretinoin Face Cream
$30 off with purchase of m4$60.0090.00 (3 month supply)
Our fragrance-free topical treatment for acne, fine lines, hyperpigmentation, and discoloration.
How to use:
Use Tretinoin after moisturizer as part of your night time routine.
M4 is clinically proven safe and effective
In an independent clinical study, statistically significant improvements seen in M4 Cream compared to placebo in just 12 weeks include:
88%68%70%57%M4 can be used with or without MHT because it does not impact blood estrogen levels. No changes in serum estriol and estradiol levels.
Read the full clinical studyScience-backed ingredients
Estriol
Increases collagen production, retains and restores skin moisture, increases skin firmness, increases skin elasticity and decreases pore size.
Ingredients
Estriol, C12 - 15 alkyl benzoate, caprylic/capric triglycerides, cetyl alcohol, ethylhexylglycerin, glycerin USP, glyceryl stearate, hydroxyethyl acrylate/sodium acryloyldimethyl, a taurate copolymer, oleic acid, olive oil, PEG-100 stearate, phenoxyethanol, polymethylsiloxane, purified water, stearic acid, trolamine NF, vitamin E acetate.
Did you know?
Up to 30% of dermal collagen is lost during the first 5 years of menopause, and decreases by an extra 2.1% every year after.
Reverse the effects of estrogen deficiency
Perimenopause, menopause, and aging mean estrogen deficiency. Estrogen deficiency means loss of collagen, decreased elasticity and loss of moisture. Our skincare was specially formulated to
- Plump and firm skin
- Shrink the appearance of pores
- Alleviate dryness and dullness
- Restore elasticity for a rejuvenated complexion
What Alloy customers are saying:
How it works
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A doctor will review and write your prescriptions.
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Related Research
Gehring, W. “Nicotinic Acid/Niacinamide and the Skin.” Journal of Cosmetic Dermatology, vol. 3, no. 2, Apr. 2004, pp. 88–93, https://doi.org/10.1111/j.1473-2130.2004.00115.x.
Griffiths, Christopher E. M. “Two Concentrations of Topical Tretinoin (Retinoic Acid) Cause Similar Improvement of Photoaging but Different Degrees of Irritation.” Archives of Dermatology, vol. 131, no. 9, 1 Sept. 1995, p. 1037, https://doi.org/10.1001/archderm.1995.01690210067011.
Hajheydari, Z., et al. “Effect of Aloe Vera Topical Gel Combined with Tretinoin in Treatment of Mild and Moderate Acne Vulgaris: A Randomized, Double-Blind, Prospective Trial.” Journal of Dermatological Treatment, 2014, www.semanticscholar.org/paper/Effect-of-Aloe-vera-topical-gel-combined-with-in-of-Hajheydari-Saeedi/2e3494d168ab7cb6428c8633ca920e1d7b06afb5.
Lephart ED, Naftolin F. Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin. Dermatol Ther (Heidelb). 2021 Feb;11(1):53-69. doi: 10.1007/s13555-020-00468-7. Epub 2020 Nov 26. PMID: 33242128; PMCID: PMC7859014.
Rzepecki AK, Murase JE, Juran R, Fabi SG, McLellan BN. Estrogen-deficient skin: The role of topical therapy. Int J Womens Dermatol. 2019 Mar 15;5(2):85-90. doi: 10.1016/j.ijwd.2019.01.001. PMID: 30997378; PMCID: PMC6451761.
Sitohang, Irma Bernadette S., et al. “Topical Tretinoin for Treating Photoaging: A Systematic Review of Randomized Controlled Trials.” International Journal of Women's Dermatology, vol. 8, no. 1, Mar. 2022, p. e003, https://doi.org/10.1097/jw9.0000000000000003.
