--- title: "Tretinoin & Estriol Trio: The Gold Standard for Menopause Skin" description: "he ultimate power move for your skin. Save $60 on the Precision Rx Trio: a prescription-strength system featuring Tretinoin and Estriol to target deep wrinkles, thinning skin, and lost elasticity." url: "https://www.myalloy.com/solutions/precision-rx-trio" --- # Tretinoin & Estriol Trio: The Gold Standard for Menopause Skin > he ultimate power move for your skin. Save $60 on the Precision Rx Trio: a prescription-strength system featuring Tretinoin and Estriol to target deep wrinkles, thinning skin, and lost elasticity. ## Precision Rx Trio *(90 days of treatment)* Type: Prescription (Rx) Tags: M4 Face Serum Rx, M4 Eye Cream Rx, Tretinoin Face Cream Rx, $339 Value Price: $279.00 Repair, renew, and restore mature skin with this next-generation collection. M4 Face Serum Rx, M4 Eye Cream Rx, and Tretinoin Face Cream Rx work in tandem to target dryness, dullness, and fine lines for visibly smoother, more youthful-looking skin. - Delivered to your door for free - Includes unlimited messaging with Alloy's menopause-expert doctors __SAVE $60 WITH THE Precision Rx Trio__ Our powerhouse skin health trio: M4 Face Serum Rx, M4 Eye Cream Rx, and Tretinoin Face Cream Rx. [Start Now](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&sku-ids%5B%5D=6ce042dd-5869-490f-b12e-126781cb0aa2%2Cb90e510a-0137-4e08-ab57-d50c81ef1c9c%2C8a4abf13-b0d5-4614-99f5-f3d1a7621b22&type=intake&skip-category-select=true) ## The results are in on M4 Eye Cream Rx In a 2025 independent clinical study, statistically significant improvements* seen in M4 Eye Cream Rx in a 12-week study include: - **25%** — improvement in wrinkle reduction - **33%** — improvement in firmness - **40%** — improvement in more elasticity - **40%** — improvement in crepiness on eyelids M4 Eye Cream Rx can be used with or without MHT because it does not impact blood estrogen levels. *Based on expert assessment ## Learn more about the Precision Rx Trio ### Details __What is it:__ Our Precision Rx Trio 3 features three products with powerful anti-aging benefits: M4 Face Serum Rx with Estriol, Peptides + Hyaluronic Acid, M4 Eye Cream Rx with Estriol + Peptides, and Tretinoin Face Cream Rx. The estriol in our M4 line replenishes what skin has lost with age to help it look smoother, bouncier, and more vibrant. And Tretinoin, a retinoid derived from vitamin A, helps speed up cell turnover to give skin a more youthful look and feel. __Who is it for:__ Women looking to fight signs of aging due to estrogen deficiency. __What am I getting:__ 1 bottle (45 grams) of M4 Face Serum Rx, 1 bottle (30 grams) of M4 Eye Cream Rx, & 1 bottle containing 30grams of Tretinoin Face Cream Rx. We offer three different strengths of Tretinoin to address individual skin needs. This set contains a 3-month supply of each. __How to get it:__ Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you. ### Suggested Use __Personalize Your Routine__ We recommend using Tretinoin as part of your nighttime routine (not morning): Step 1: Gently wash your face to remove dirt, oil, and makeup. Step 2: Apply 1 pump of M4 Eye Cream Rx around the entire eye area. Step 3: Step 3: Apply 2 pumps of M4 Face Serum Rx to face and neck, avoiding eye area. Step 4: Apply a nighttime moisturizer. Step 5: Apply a pea-sized amount of Tretinoin Face Cream Rx to forehead, cheeks, and chin. Avoid eyelids and corners around mouth and nose. Start with 2–3 nights per week; increase as tolerated. Avoid mixing with other exfoliating actives (e.g., AHAs, BHAs) initially. Do not use harsh skin products that contain ingredients such as benzoyl peroxide, resorcinol, salicylic acid, or sulfur. __Heads up!__ If you're using your product for the first time, you may need to pump the bottle several times before the product starts to dispense. This is totally normal, sometimes it just takes a few pumps to get things flowing. Once it’s primed, you’re good to go! ### Safety Information - M4 products are suitable for all skin types including sensitive skin and are safe to use with your other skincare solutions. - They are also safe to use with Menopausal Hormone Therapy; a clinical study found that there is no increase in estriol levels in the blood after using M4. - We recommend performing a “patch test” for a few days by applying a small amount to one area of your face or neck. - Discontinue if irritation occurs. - If you have a history of melasma, we recommend starting with a very small amount and increasing slowly. Discontinue if worsening melasma occurs. - Do not use Tretinoin if pregnant or breastfeeding. Apply sunscreen with SPF 30+ every morning while using. Tretinoin makes your skin more sensitive to sunlight, especially in the first 6 months. In the first 2-4 weeks of use, apply once every other night and increase to nightly as your skin tolerates. If irritation persists, stop use of the product. - Note: Tretinoin can cause redness, mild burning, dryness, peeling and sun sensitivity. These should subside as your skin adjusts. ### Estriol Is a Game-changer Prescription-strength topical estriol has been proven to significantly improve (and even reverse) signs of aging. Estriol promotes collagen production, hydrates deeply, and strengthens the skin’s structure for younger-looking, more radiant skin. ### Real Women Love It 76% of women who tried Alloy’s M4 Eye Cream Rx found their skin looked smoother and the product softened the look of wrinkles and crow’s feet. ### How Tretinoin Works Tretinoin has been used to treat mild to moderate acne for almost 50 years. It is also known as retinoic acid, and it’s the generic name for synthetic vitamin A. It works by speeding up cell turnover, which gives your skin a more youthful look and feel. ![Woman smiling putting on eye cream](https://images.ctfassets.net/md0kv0ejg0xf/7MMbuvc76PVBntbOY2RMzw/c51a5f0e8e14a55b3f70b805cfdc9eec/Skin_Cream_Rectangle.png) *Did you know?* ### Skin elasticity can decline by as much as 20% in the first two years post-menopause. ### What is Estriol? Estriol is one of three forms of estrogen our bodies naturally produce, until menopause. Once we hit menopause, we lose up to 30% of our dermal collagen in the first five years alone. And it only goes down from there. The solution to losing estrogen is replenishing it, and that's where estriol comes in. Research shows that topical estriol can address hormonal aging and helps keep skin resilient, youthful, and balanced. Topical estriol stays on the surface of your skin and doesn’t enter your bloodstream, making it safe for everyday use. ### What is Tretinoin? Tretinoin as a topical skin treatment isn’t new. It’s been used to treat mild to moderate acne for almost 50 years. Tretinoin is also known as retinoic acid, and it’s the generic name for synthetic vitamin A. Tretinoin Face Cream Rx is a prescription-strength topical cream or gel that is used mainly to treat acne, fine lines, hyperpigmentation, and discoloration. Tretinoin is able to speed up the life cycle of skin cells, making them divide faster and die faster, so newer, healthier cells can take their place. ### How Alloy Works We make it easy to connect directly with a menopause-specialized physician. [Find Your Plan](https://secure.myalloy.com/experience) **Tell Us About Yourself (5-10 minutes)** Fill out an intake form to share your symptoms, health history, and goals **Get a Treatment Plan (less than 12 hours)** Your expert doctor will create a personalized plan based on your needs. **Free Delivery to Your Door** Get your prescriptions sent right to your home with free shipping **24/7 Care + Ongoing Support** Get unlimited access to your doctor, support groups, and more ## Frequently asked questions ### Are the M4 products right for me? Most women are good candidates. A doctor will confirm after a quick assessment. ### Can I use them with hormone therapy? Yes—all M4 products are non-systemic and safe with MHT and vaginal estrogen. ### What is Tretinoin and why is it prescribed? Tretinoin is a retinoid derived from vitamin A. It is used to treat acne, fine lines and wrinkles, discoloration, and hyperpigmentation. ### Can I use Tretinoin Face Cream Rx with Hormone Replacement Therapy? Tretinoin Face Cream Rx is safe to use with any of Alloy’s options for Hormone Replacement Therapy, vaginal estradiol, and M4 products. Your doctor will review all of the medications you’re taking before prescribing and determine if Tretinoin Face Cream Rx is right for you. ### When should I start using the M4 Skincare line? M4 was made for women in perimenopause and menopause—the life stages when hormonal changes start to visibly affect the skin causing dryness, fine lines, and loss of radiance. Perimenopause typically begins in your 40s, though it can start as early as your mid-30s. By age 50, women can lose up to 50% of their total collagen compared to peak levels. If you’re in perimenopause, M4 is a smart way to get ahead of the curve. Topical estriol, the star ingredient in our formulas, helps keep skin resilient, youthful, and balanced—before signs of aging deepen. And if you’re already in menopause, M4 is designed to restore what hormonal shifts have taken away: firmness, hydration, and that healthy glow. ### Where is Alloy available? All 50 U.S. states and D.C. (Global users can still access our content & resources.) [Learn More](https://myalloy.zendesk.com/hc/en-us) ## What our customers are saying: ### The Alloy Promise At Alloy Health, we believe every woman deserves thoughtful, evidence-based care, and the information she needs to make confident decisions about her health based on facts, not fear. Our board-certified physicians follow guidelines from leading medical organizations including ACOG and The Menopause Society and recommend treatments tailored to each patient. [Learn more](https://www.myalloy.com/compounded-products) ![The Alloy Promise](https://images.ctfassets.net/md0kv0ejg0xf/5S3J54W7j0MPpyLNbGg2WF/96e117713fd5bd6ddfc07bb92e5b73e6/Group_80197.png) --- *This is a markdown version of [https://www.myalloy.com/solutions/precision-rx-trio](https://www.myalloy.com/solutions/precision-rx-trio) for AI/LLM consumption.*