--- title: "Stronger Than Retinol: The Estriol & Tretinoin Power Pair for Midlife" description: "This prescription-strength duo combines M4 Face Cream Rx with Tretinoin Face Cream Rx to enhance collagen production, smooth the skin, & reduce signs of aging." url: "https://www.myalloy.com/solutions/power-pair-set" --- # Stronger Than Retinol: The Estriol & Tretinoin Power Pair for Midlife > This prescription-strength duo combines M4 Face Cream Rx with Tretinoin Face Cream Rx to enhance collagen production, smooth the skin, & reduce signs of aging. ## Power Pair Set *3-month supply* Type: Prescription (Rx) Tags: New customers, extra $10 off with code SUN10, Estriol, Plant Based, Bioidentical Price: $210.00 (regularly $240.00) Estriol rebuilds, tretinoin renews. Together, this power pair delivers. M4 Face Cream Rx with Estriol and Vitamin E supports collagen production, restores hydration, and improves elasticity. Tretinoin renews the surface with Niacinamide and Aloe, it speeds cell turnover to smooth texture and soften signs of sun damage. - Includes $0 unlimited doctor access - Delivered to your door for free - HSA and FSA Eligible [Start Now](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&sku-ids%5B%5D=d7fe4df5-7fd8-42c1-86d5-9be36bd6833c%2C8a4abf13-b0d5-4614-99f5-f3d1a7621b22&skip-category-select=true&type=intake) ## M4 is clinically proven to be powerfully effective. In an independent clinical study, statistically significant improvements seen in M4 Face Cream Rx compared to placebo in just 12 weeks include:* ## 88% improvement in elasticity ## 70% improvement in hydration ## 68% improvement in overall skin health ## 57% improvement in skin texture ## Learn more about the Power Pair Set ### Details __What is it:__ The Power Pair Set includes M4 Face Cream Rx with Estriol and Vitamin E and Tretinoin Face Cream Rx with Niacinamide and Aloe. Use Tretinoin to smooth and renew the surface plus reduce signs of sun damage, and estriol to rebuild and fortify deeper layers to make skin look and feel younger. __Who is it for:__ Women looking to fight signs of aging due to estrogen deficiency. __What am I getting:__ 1 bottle (45 grams) of M4 Face Cream Rx & 1 bottle (30 grams) of Tretinoin Face Cream Rx. Alloy offers three different strengths of Tretinoin to address individual skin needs. This set contains a 3-month supply of each. __How to get it:__ Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you. ### Suggested Use Morning or Night Routine - Cleanse face - Apply toners/serums - Apply 2 pumps of M4 Face Cream Rx to face and neck, avoiding eye area - Apply a pea-sized amount (about ½ pump) of Tretinoin Face Cream Rx to forehead, cheeks, and chin. Avoid eyelids and corners around mouth and nose. __Morning:__ Follow with moisturizer and SPF. __Night:__ Follow with nighttime moisturizer. __Heads up!__ If you're using your product for the first time, you may need to pump the bottle several times before the product starts to dispense. This is totally normal, sometimes it just takes a few pumps to get things flowing. Once it’s primed, you’re good to go! ### Safety Information - M4 products are suitable for all skin types including sensitive skin and are safe to use with your other skincare solutions. - They are also safe to use with Menopausal Hormone Therapy; a clinical study found that there is no increase in estriol levels in the blood after using M4. - We recommend performing a “patch test” for a few days by applying a small amount to one area of your face or neck. - Discontinue if irritation occurs. - If you have a history of melasma, we recommend starting with a very small amount and increasing slowly. Discontinue if worsening melasma occurs. ![Woman smiling putting on eye cream](https://images.ctfassets.net/md0kv0ejg0xf/7MMbuvc76PVBntbOY2RMzw/c51a5f0e8e14a55b3f70b805cfdc9eec/Skin_Cream_Rectangle.png) *DID YOU KNOW?* ### Up to 30% of your dermal collagen is lost in the first 5 years of menopause, with another 2.1% lost every year after. ### What is Estriol? Estriol is one of three forms of estrogen our bodies naturally produce, until menopause. Once we hit menopause, we lose up to 30% of our dermal collagen in the first five years alone. And it only goes down from there. The solution to losing estrogen is replenishing it, and that's where estriol comes in. Research shows that topical estriol can address hormonal aging and helps keep skin resilient, youthful, and balanced. Topical estriol stays on the surface of your skin and doesn’t enter your bloodstream, making it safe for everyday use. ### What is Tretinoin? Tretinoin as a topical skin treatment isn’t new. It’s been used to treat mild to moderate acne for almost 50 years. Tretinoin is also known as retinoic acid, and it’s the generic name for synthetic vitamin A. Tretinoin Face Cream Rx is a prescription-strength topical cream or gel that is used mainly to treat acne, fine lines, hyperpigmentation, and discoloration. Tretinoin is able to speed up the life cycle of skin cells, making them divide faster and die faster, so newer, healthier cells can take their place. ## Real Alloy Customers. Real Results. ## Frequently asked questions ### How do I know if M4 Face Cream Rx is right for me? Most women are good candidates. A doctor will confirm after a quick assessment. ### Can I use it with hormone therapy? Yes—all M4 products are non-systemic and safe with MHT and vaginal estrogen. ### Do I need progesterone? No—because M4 is not systemic, progesterone is not required. ### How do I know if Tretinoin Face Cream Rx is right for me? Your menopause-trained doctor will review your intake and help determine if Tretinoin is right for you. ### Can I use Tretinoin Face Cream Rx with Hormone Replacement Therapy? Tretinoin Face Cream Rx is safe to use with any of Alloy’s options for Hormone Replacement Therapy, vaginal estradiol, and M4 products. Your doctor will review all of the medications you’re taking before prescribing and determine if Tretinoin Face Cream Rx is right for you. ### What is Tretinoin and why is it prescribed? Tretinoin is a retinoid derived from vitamin A. It is used to treat acne, fine lines and wrinkles, discoloration, and hyperpigmentation. ### Where is Alloy available? All 50 U.S. states and D.C. (Global users can still access our content & resources.) ## The Alloy Promise At Alloy Health, we believe every woman deserves thoughtful, evidence-based care, and the information she needs to make confident decisions about her health based on facts, not fear. Our board-certified physicians follow guidelines from leading medical organizations including ACOG and The Menopause Society and recommend treatments tailored to each patient. ##### [Learn more](https://www.myalloy.com/who-we-are) ![The Alloy Promise - Small](https://images.ctfassets.net/md0kv0ejg0xf/1OxkVrKzucAIz3XjYr4dC7/a4d065b4ff812e2c000fbcd7568b4df0/Alloy_Promise.png) --- *This is a markdown version of [https://www.myalloy.com/solutions/power-pair-set](https://www.myalloy.com/solutions/power-pair-set) for AI/LLM consumption.*