--- title: "Estrogen Face Cream: M4 Anti-Aging Estriol | Alloy" description: "Revitalize menopausal skin with M4, our prescription estrogen face cream. Formulated with estriol to boost collagen, reduce wrinkles, and restore skin elasticity. Shop now" url: "https://www.myalloy.com/solutions/m4" --- # Estrogen Face Cream: M4 Anti-Aging Estriol | Alloy > Revitalize menopausal skin with M4, our prescription estrogen face cream. Formulated with estriol to boost collagen, reduce wrinkles, and restore skin elasticity. Shop now ## M4 Face Cream Rx *3-month supply* Type: Prescription (Rx) Tags: Estriol, Plant Based , Bioidentical Price: $150.00 Estrogen-powered anti-aging cream that hydrates, restores elasticity, and rebuilds collagen. Clinically proven to improve firmness, bounce, and texture in 12 weeks—with up to 88% improvement in elasticity. Gentle and non-comedogenic. - Includes $0 unlimited doctor access - Delivered to your door for free - HSA/FSA Eligible [Start Now](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&sku-ids%5B%5D=d7fe4df5-7fd8-42c1-86d5-9be36bd6833c&skip-category-select=true&type=intake) ## M4 is clinically proven to be powerfully effective In an independent clinical study, statistically significant improvements seen in M4 Face Cream Rx compared to placebo in just 12 weeks include: - **88%** — improvement in elasticity - **70%** — improvement in hydration - **68%** — improvement in overall skin health - **57%** — improvement in skin texture M4 Face Cream Rx can be used with or without HRT because it does not impact blood estrogen levels. ## Learn more about M4 Face Cream Rx ### Details __What is it:__ A clinically proven, fragrance-free, prescription, estrogen-based face cream we created specifically for perimenopausal and menopausal women. The combination of increased hydration and collagen stimulation is a major innovation that helps address and prevent signs of aging. Full list of ingredients: estriol, C12-15 alkyl benzoate, caprylic/capric triglyceride, cetyl alcohol, ethylhexylglycerin, glycerin, glyceryl stearate, hydroxyethyl acrylate/sodium, acryloyldimethyl taurate copolymer, oleic acid, olea europaea (olive) fruit oil, PEG-100 stearate, phenoxyethanol, dimethicone, polymethylsiloxane, water (aqua), stearic acid, trolamine, vitamin E acetate. __Who is it for:__ M4 was made for women in perimenopause and menopause—the life stages when hormonal changes start to visibly affect the skin, causing dryness, fine lines, and loss of radiance. __What am I getting:__ 1 bottle containing (3-month supply) of M4 Face Cream Rx. __How to get it:__ Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you. ### Suggested Use Adding M4 Face Cream Rx to your morning or nighttime skincare routine is easy, and it’s safe to use with your other skincare products. Morning or Night Routine 1. Cleanse face 2. Apply toners/serums 3. Apply 2 pumps of M4 Face Cream Rx to face and neck, avoiding eye area 4. Morning: Follow with moisturizer and SPF Night: Follow with nighttime moisturizer and any retinols (if you use them) ### Safety Information - M4 Face Cream Rx is suitable for all skin types including sensitive skin and is safe to use with other skincare solutions. - It is also safe to use with Menopausal Hormone Therapy: a clinical study found that there is no increase in estriol levels in the blood after using M4. - We recommend performing a “patch test” for a few days by applying a small amount to one area of your face or neck. - Discontinue if irritation occurs. - If you have a history of melasma, we recommend starting with a very small amount and increasing slowly. Discontinue if worsening melasma occurs. ### Bounce Back with M4 Topical estriol, the star ingredient in our formulas, helps keep skin resilient, youthful, and balanced—before signs of aging deepen. And if you’re already in menopause, M4 is designed to restore what hormonal shifts have taken away: firmness, hydration, and that healthy glow. ### Real Customers Love It In a 2025 survey, 92% of Alloy’s M4 Face Cream Rx users said they’d recommend it to a friend because it delivered real results they could see. ### See Results in as Little as 12 Weeks While timelines vary, most people see significant improvements in their skin within three months. ### The M4 Difference Our three powerful M4 products (M4 Face Cream Rx, M4 Face Serum Rx, and M4 Eye Cream Rx) boost collagen production, restore hydration, improve elasticity, and support hormonal skin repair, keeping skin resilient, youthful, and balanced. Each M4 product delivers results on its own—but together, they’re a complete anti-aging powerhouse. Get 25% off when you bundle all three and see what your skin’s been missing. Aging has never looked better. [Get Our Exclusive M4 Set](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&skip-category-select=true&type=intake) ![M4 Set No Background](https://images.ctfassets.net/md0kv0ejg0xf/3yF9Hi89CJHYcdkj0PBnMk/26f64d4776078b7381accb56a646412c/M4_PDP_Banner.png) ![Woman smiling putting on eye cream](https://images.ctfassets.net/md0kv0ejg0xf/7MMbuvc76PVBntbOY2RMzw/c51a5f0e8e14a55b3f70b805cfdc9eec/Skin_Cream_Rectangle.png) *Did you know?* ### Up to 30% of dermal collagen is lost in the first 5 years of menopause—with another 2.1% lost every year after. ![Estriol Ingredient](https://images.ctfassets.net/md0kv0ejg0xf/4JpODwmdYBdEZxRXqMEr95/6c1196fd59f2349b1681dfd843fb8c44/Estriol__1_.png) *KEY M4 SKINCARE INGREDIENT: ESTRIOL* ### What is Estriol? Estriol is one of three forms of estrogen our bodies naturally produce, until menopause. Once we hit menopause, we lose up to 30% of our dermal collagen in the first five years alone. And it only goes down from there. The solution to losing estrogen is replenishing it, and that's where estriol comes in. Research shows that topical estriol can address hormonal aging and helps keep skin resilient, youthful, and balanced. Topical estriol stays on the surface of your skin and doesn’t enter your bloodstream, making it safe for everyday use. [Get Skincare Rx](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&skip-category-select=true&type=intake) ### How Alloy Works We make it easy to connect directly with a menopause-specialized physician. [Find Your Plan](https://secure.myalloy.com/experience) **Tell Us About Yourself (5-10 minutes)** Fill out an intake form to share your symptoms, health history, and goals **Get a Treatment Plan (less than 12 hours)** Your expert doctor will create a personalized plan based on your needs. **Free Delivery to Your Door** Get your prescriptions sent right to your home with free shipping **24/7 Care + Ongoing Support** Get unlimited access to your doctor, support groups, and more ## Frequently asked questions ### Can I use this with hormone therapy? Yes — M4 Face Cream Rx is non-systemic and safe with MHT and vaginal estrogen. ### What is Tretinoin and why is it prescribed? Tretinoin is a retinoid derived from vitamin A. It is used to treat acne, fine lines and wrinkles, discoloration, and hyperpigmentation. ### Do I need progesterone? No—because M4 is not systemic, progesterone is not required. ### Is M4 Rx eligible for HSA or FSA reimbursement? Yes! Medications prescribed by a licensed provider are eligible to be paid for or reimbursed by your HSA or FSA. Your invoice is available to download and include when you submit to your plan for reimbursement. If you require more information, please contact us at support@myalloy.com and we will assist you. Note: The IRS defines which medical expenses are eligible under an HSA or FSA and the products carried on Alloy are in compliance with these requirements. However, these plans can vary and some may not allow all eligible HSA or FSA expenses. It's important to always check with your benefits administrator to determine which expenses are eligible before you shop. ### Where is Alloy available? All 50 U.S. states and D.C. (Global users can still access our content & resources.) ## What our customers are saying: ### The Alloy Promise At Alloy Health, we believe every woman deserves thoughtful, evidence-based care, and the information she needs to make confident decisions about her health based on facts, not fear. Our board-certified physicians follow guidelines from leading medical organizations including ACOG and The Menopause Society and recommend treatments tailored to each patient. [Learn more](https://www.myalloy.com/compounded-products) ![The Alloy Promise](https://images.ctfassets.net/md0kv0ejg0xf/5S3J54W7j0MPpyLNbGg2WF/96e117713fd5bd6ddfc07bb92e5b73e6/Group_80197.png) --- *This is a markdown version of [https://www.myalloy.com/solutions/m4](https://www.myalloy.com/solutions/m4) for AI/LLM consumption.*