--- title: "Full Body Skin Cream - Hydrating Lotion for Women in Menopause" description: "Our head to toe body treatment has been clinically tested to provide an 88% improvement in elasticity, 70% improvement in hydration, and a 57% improvement in skin texture." url: "https://www.myalloy.com/solutions/m4-head-to-toe-set" --- # Full Body Skin Cream - Hydrating Lotion for Women in Menopause > Our head to toe body treatment has been clinically tested to provide an 88% improvement in elasticity, 70% improvement in hydration, and a 57% improvement in skin texture. ## M4® Head to Toe Set *3-month supply* Type: Prescription (Rx) Tags: Bundle and Save $100, Estriol, Peptides, Plant Based, Bioidentical Price: $335.00 (regularly $435.00) Three clinically proven, estriol-based formulas, designed to work together for exceptional results. This head to toe powerhouse team is proven to boost collagen production, hydrate, firm, and restore the skin on your face, eye, and body. - Includes $0 unlimited doctor access - Delivered to your door for free - HSA/FSA Eligible [Start Now](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&sku-ids%5B%5D=14ad4b82-70a1-40e6-a8b8-17e64e49afee&skip-category-select=true&type=intake) ## Confirmed by Experts. Felt by Real Women. In three independent clinical studies.* ## __4.6__ stars from 2k Trustpilot skin reviews ## __95%__ felt smoother skin with M4 Body Treatment ## __88%__ improved elasticity with M4 Face Cream ## __20%__ more supple skin with M4 Eye Cream ## Learn more about M4 Head to Toe Set ### Details __What is it:__ Alloy’s full-body prescription skin protocol, designed for women who want to combat the effects of estrogen loss in menopause and perimenopause. It combines our bestselling M4 eye & face solutions with the first-ever prescription estriol + peptide body treatment. - M4 Face Cream Rx: Provides deep hydration, rebuilds collagen, and improves elasticity - M4 Eye Cream Rx: Targets fine lines, thinning skin, and crepiness around the eyes - M4 Body Treatment Rx: Clinically proven to firm, smooth, hydrate, and restore elasticity on hands, chest, and knees: triple-validated by instruments, experts, and real women. __Who is it for:__ Women in perimenopause or menopause who notice crepiness, dryness, or loss of firmness on their arms, chest, legs, or knees and want real solutions, not just promises. If you already love M4 Face Cream and want those same clinically proven results on your body, this is the routine you've been waiting for. It's your complete prescription: face and body, done. __What am I getting:__ 1 bottle M4 Face Cream Rx, 1 bottle M4 Eye Cream Rx, 1 bottle M4 Body Treatment Rx. This is a 3-month supply. __How to get it:__ Prescription required. A menopause-specialized doctor will review your medical history to determine if this is the right treatment for you. ### Suggested Use __Complete Anti-Aging Routine__ __Step 1: Treat the Eye Area__ On clean skin, apply 1 pump of M4® Eye Cream Rx to each under-eye and lid area __Step 2: Treat the Face__ Apply 2 pumps of M4® Face Cream Rx __Step 3: Lock In & Protect__ Finish your routine with the essentials to seal in hydration and protect your skin. AM: Follow with a moisturizer, SPF, and makeup as needed. PM: Apply a moisturizer or retinoid—like Alloy’s Tretinoin Face Cream Rx—as directed by your provider __Step 4: Treat Your Body__ Apply 1 full pump of M4 Body Treatment Rx to targeted area such as your chest, hands, legs above the knees or stomach. Allow it to absorb fully. ### Safety Information Always follow your physician’s instructions. M4 Skincare Rx Body is a topical estriol treatment and is non-systemic. It does not impact blood estrogen levels and does not require progesterone and can be used alongside HRT (Hormone Replacement Therapy), vaginal estrogen, and other M4 products. Consult your doctor before starting if you have any medical concerns. ![Woman in Swimsuit](https://images.ctfassets.net/md0kv0ejg0xf/2H3WFxLKRrYuvRRm7Nnej9/5cd0c6923608b60ff8be7cd26b114185/GettyImages-1125234724-4x3.jpg) *BRAVO @MYALLOY* ### "I'm 56 and have been using these products for a few months now and am blown away. My skin is soft and hydrated. Big fan. " - Susie via Instagram *THE M4 DIFFERENCE* ### The Original Estriol-Based Prescription Skincare Collection Alloy was the first to harness the power of estriol to combat the effects of hormone loss in your skin. Created by experts, trusted by doctors, and loved by women everywhere, the M4 collection is designed to work together. Each product is clinically proven to rebuild collagen, restore moisture, increase elasticity, and reduce wrinkles where you need it most. [View All Skincare](https://www.myalloy.com/skincare) ![M4 Bottles with Blocks](https://images.ctfassets.net/md0kv0ejg0xf/6XX0ZathjGTUSAip3l3MkH/01f12128e274eb48852360fa8057b7e0/BottleWithBlocks.png) ![Estriol Ingredient](https://images.ctfassets.net/md0kv0ejg0xf/4JpODwmdYBdEZxRXqMEr95/6c1196fd59f2349b1681dfd843fb8c44/Estriol__1_.png) *M4 Active Ingredient: Estriol* ### Estriol, a form of estrogen and the powerhouse ingredient in our M4 products, builds collagen, increases elasticity, and restores moisture. ## Real Alloy Customers. Real Results. ## Frequently asked questions ### Are the M4 products right for me? Most women are good candidates. A doctor will confirm after a quick assessment. ### Can I use this with hormone therapy? Yes. You can use M4 Skincare Rx with Menopausal Hormone Therapy (MHT) and vaginal estrogen, since it is not systemic and therefore not absorbed by your bloodstream. ### What were the results of the clinical studies of M4 products? In three independent clinical studies (one on M4 Face Cream Rx in 2024 and one on M4 Eye Cream Rx in 2025 & M4 Body Treatment in 2026), results showed statistically significant improvements in hydration, elasticity, firmness, and overall skin health. Efficacy and safety results for these studies were verified by dermatology experts. __2024 Study to Assess the Facial Anti-Aging Efficacy of Topical Estriol and Estradiol__ Improvements seen in M4 Face Cream Rx with Estriol compared to placebo in 12 weeks include: 88% improvement in elasticity 70% improvement in hydration 68% improvement in overall skin health 57% improvement in skin texture __2025 Study to Evaluate the Efficacy of Estriol Eye Cream__ Improvements seen in M4 Eye Cream Rx in 12 weeks include: Up to 25% wrinkle reduction Up to 33% firmer looking skin* Up to 40% more elasticity* Up to 40% less crepiness on the eyelids* Immediately boosted hydration by 23%** __2026 Study to Evaluate the Efficacy of Estriol Body Cream__ Improvements seen in M4 Body Cream Rx on chest and legs in 12 weeks include: 18% improvement in skin hydration upon application 11% less crepiness on the chest 18% smoother skin texture on the chest 11% firmer looking skin on the chest and legs 7% improvement in skin elasticity *Based on Expert Assessment **Based on Instrumentation ### When should I start using the M4 Skincare line? M4 was made for women in perimenopause and menopause—the life stages when hormonal changes start to visibly affect the skin causing dryness, fine lines, and loss of radiance. Perimenopause typically begins in your 40s, though it can start as early as your mid-30s. By age 50, women can lose up to 50% of their total collagen compared to peak levels. If you’re in perimenopause, M4 is a smart way to get ahead of the curve. Topical estriol, the star ingredient in our formulas, helps keep skin resilient, youthful, and balanced—before signs of aging deepen. And if you’re already in menopause, M4 is designed to restore what hormonal shifts have taken away: firmness, hydration, and that healthy glow. ### Do I need progesterone? No—because M4 is not systemic, progesterone is not required. ### Is M4 Rx eligible for HSA or FSA reimbursement? Yes! Medications prescribed by a licensed provider are eligible to be paid for or reimbursed by your HSA or FSA. Your invoice is available to download and include when you submit to your plan for reimbursement. If you require more information, please contact us at support@myalloy.com and we will assist you. Note: The IRS defines which medical expenses are eligible under an HSA or FSA and the products carried on Alloy are in compliance with these requirements. However, these plans can vary and some may not allow all eligible HSA or FSA expenses. It's important to always check with your benefits administrator to determine which expenses are eligible before you shop. ### Where is Alloy available? All 50 U.S. states and D.C. (Global users can still access our content & resources.) ## The Alloy Promise At Alloy Health, we believe every woman deserves thoughtful, evidence-based care, and the information she needs to make confident decisions about her health based on facts, not fear. Our board-certified physicians follow guidelines from leading medical organizations including ACOG and The Menopause Society and recommend treatments tailored to each patient. ##### [Learn more](https://www.myalloy.com/who-we-are) ![The Alloy Promise - Small](https://images.ctfassets.net/md0kv0ejg0xf/1OxkVrKzucAIz3XjYr4dC7/a4d065b4ff812e2c000fbcd7568b4df0/Alloy_Promise.png) ### Disclosures *2024 Study: Based on a 12-week randomized, double-blind, placebo-controlled clinical study (n=86) using Corneometer®, Cutometer®, and dermaspectrophotometer instrumental measurements, investigator clinical grading, and subject self-asses 2025 Study: Based on a 12-week clinical study (n=34) using Corneometer®, Moisturemeter EpiD, Cutometer®, and Antera 3D® instrumental measurements, expert visual and tactile grading, and self-assessment questionnaire. 2026 Study: Based on a 12-week clinical study (n=38) using Corneometer®, Moisturemeter EpiD, Cutometer®, and Antera 3D® instrumental measurements, expert visual and tactile grading, and self-assessment questionnaire. --- *This is a markdown version of [https://www.myalloy.com/solutions/m4-head-to-toe-set](https://www.myalloy.com/solutions/m4-head-to-toe-set) for AI/LLM consumption.*