--- title: "Prescription Estriol Face Serum: Reverse Hormonal Collagen Loss" description: "This prescription-strength serum with estriol, peptides, and hyaluronic acid visibly improves firmness, hydration, and radiance." url: "https://www.myalloy.com/solutions/m4-estriol-peptide-face-serum" --- # Prescription Estriol Face Serum: Reverse Hormonal Collagen Loss > This prescription-strength serum with estriol, peptides, and hyaluronic acid visibly improves firmness, hydration, and radiance. ## M4 Face Serum Rx *3-month supply* Type: Prescription (Rx) Tags: Winner: Oprah Daily's Menopause O-wards Best Prescription-Strength Serum, Estriol, Peptides, Plant Based, Bioidentical Price: $159.00 M4 Face Serum Rx with Estriol and Peptides is a comprehensive anti-aging treatment that targets fine lines, dryness, and loss of firmness. A powerful blend designed to hydrate, smooth, and visibly renew skin as it ages. - Includes $0 unlimited doctor access - Delivered to your door for free - HSA/FSA Eligible [Start Now](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&sku-ids%5B%5D=6ce042dd-5869-490f-b12e-126781cb0aa2&skip-category-select=true&type=intake) ## M4 is clinically proven to be powerfully effective In an independent clinical study, statistically significant improvements seen in M4 Face Cream Rx compared to placebo in just 12 weeks include: - **88%** — improvement in elasticity - **70%** — improvement in hydration - **68%** — improvement in overall skin health - **57%** — improvement in skin texture M4 Face Cream Rx can be used with or without HRT because it does not impact blood estrogen levels. ## Learn more about M4 Face Serum Rx ### Details __What is it:__ M4 Face Serum Rx with Estriol, Peptides, and Hyaluronic Acid is a targeted daily dose of rejuvenation. The fragrance-free formula restores hydration and elasticity, boosts collagen production, reduces fine lines and wrinkles, reverses sun damage, enhances skin radiance, improves firmness and smoothness, and supports hormonal skin repair for healthier, more youthful-looking and acting skin. __Who is it for:__ M4 was made for women in perimenopause and menopause—the life stages when hormonal changes start to visibly affect the skin, causing dryness, fine lines, and loss of radiance. __What am I getting:__ 1 bottle (3-month supply) of M4 Face Serum Rx. __How to get it:__ Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you. Contact support@myalloy.com for more questions. ### Suggested Use Adding M4 Face Serum Rx to your morning or nighttime skincare routine is easy, and it can be used with your other skincare products. Morning or Night Routine - Cleanse face - Apply eye cream - Apply 2 pumps of M4 Face Serum Rx to face and neck, avoiding eye area Morning: Follow with moisturizer and your SPF of choice. Night: Follow with moisturizer and any retinols (if you use them). ### Safety Information - Suitable for all skin types, including sensitive skin - Non-systemic: does not increase hormone levels in the blood - Safe to use with Menopausal Hormone Therapy (MHT) and vaginal estrogen - If you have melasma, start with a small amount and monitor closely - Discontinue use if irritation or melasma worsens ### M4 Goes Deeper Unlike surface-level serums, M4 deeply stimulates cellular renewal, repairs sun damage, and reverses hormonal aging—restoring firmness, boosting radiance, and visibly reducing fine lines, wrinkles, and dullness. ### Powerful Ingredients Estriol promotes collagen production, hydrates deeply, and addresses hormonal aging. Palmitoyl pentapeptide-4 and acetyl hexapeptide-8 support collagen production and improve skin texture, firmness, and elasticity. ### Real Results This clinically proven level of skin care is only available by prescription. While timelines vary, most people see results within 12 weeks. ### The M4 Difference Our three powerful M4 products (M4 Face Cream Rx, M4 Face Serum Rx, and M4 Eye Cream Rx) boost collagen production, restore hydration, improve elasticity, and support hormonal skin repair, keeping skin resilient, youthful, and balanced. Each M4 product delivers results on its own—but together, they’re a complete anti-aging powerhouse. Get 25% off when you bundle all three and see what your skin’s been missing. Aging has never looked better. [Get Our Exclusive M4 Set](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&skip-category-select=true&type=intake) ![M4 Set No Background](https://images.ctfassets.net/md0kv0ejg0xf/3yF9Hi89CJHYcdkj0PBnMk/26f64d4776078b7381accb56a646412c/M4_PDP_Banner.png) ![Woman smiling putting on eye cream](https://images.ctfassets.net/md0kv0ejg0xf/7MMbuvc76PVBntbOY2RMzw/c51a5f0e8e14a55b3f70b805cfdc9eec/Skin_Cream_Rectangle.png) *Did you know?* ### Up to 30% of dermal collagen is lost in the first 5 years of menopause—with another 2.1% lost every year after. ![Estriol Ingredient](https://images.ctfassets.net/md0kv0ejg0xf/4JpODwmdYBdEZxRXqMEr95/6c1196fd59f2349b1681dfd843fb8c44/Estriol__1_.png) *KEY M4 SKINCARE INGREDIENT: ESTRIOL* ### What is Estriol? Estriol is one of three forms of estrogen our bodies naturally produce, until menopause. Once we hit menopause, we lose up to 30% of our dermal collagen in the first five years alone. And it only goes down from there. The solution to losing estrogen is replenishing it, and that's where estriol comes in. Research shows that topical estriol can address hormonal aging and helps keep skin resilient, youthful, and balanced. Topical estriol stays on the surface of your skin and doesn’t enter your bloodstream, making it safe for everyday use. [Get Skincare Rx](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&skip-category-select=true&type=intake) ### How Alloy Works We make it easy to connect directly with a menopause-specialized physician. [Find Your Plan](https://secure.myalloy.com/experience) **Tell Us About Yourself (5-10 minutes)** Fill out an intake form to share your symptoms, health history, and goals **Get a Treatment Plan (less than 12 hours)** Your expert doctor will create a personalized plan based on your needs. **Free Delivery to Your Door** Get your prescriptions sent right to your home with free shipping **24/7 Care + Ongoing Support** Get unlimited access to your doctor, support groups, and more ## Frequently asked questions ### How do I know if M4 Face Serum Rx is right for me? Most women can use M4 Face Serum Rx. Before your doctor prescribes M4 Face Serum Rx, you’ll fill out a quick assessment, and they will review it to make sure it’s right for you. ### Can I use M4 Face Serum Rx with other forms of hormone treatment? Yes. You can use M4 Face Serum Rx with Hormone Replacement Therapy (HRT) and vaginal estrogen, since it is not systemic and therefore not absorbed by your bloodstream. ### Do I need progesterone? No—because M4 is not systemic, progesterone is not required. ### Where is Alloy available? All 50 U.S. states and D.C. (Global users can still access our content & resources.) [Learn More](https://myalloy.zendesk.com/hc/en-us) - [The First (and Only) Eye Cream with Estriol](https://www.myalloy.com/blog/the-first-and-only-eye-cream-with-estriol) - [A Guide to Layering Skincare (and Adding M4 into Your Routine)](https://www.myalloy.com/blog/a-guide-to-layering-skincare-and-adding-m4-into-your-routine) - [Peptides for Menopause Skin Care: Benefits, Ingredients & Routine Tips](https://www.myalloy.com/blog/peptides-101-how-do-they-work) - [The Menopause Eye Shift: Vision Changes and Dry Eye](https://www.myalloy.com/blog/the-menopause-eye-shift-vision-changes-and-dry-eye) ## What our customers are saying: ### The Alloy Promise At Alloy Health, we believe every woman deserves thoughtful, evidence-based care, and the information she needs to make confident decisions about her health based on facts, not fear. Our board-certified physicians follow guidelines from leading medical organizations including ACOG and The Menopause Society and recommend treatments tailored to each patient. [Learn more](https://www.myalloy.com/compounded-products) ![The Alloy Promise](https://images.ctfassets.net/md0kv0ejg0xf/5S3J54W7j0MPpyLNbGg2WF/96e117713fd5bd6ddfc07bb92e5b73e6/Group_80197.png) --- *This is a markdown version of [https://www.myalloy.com/solutions/m4-estriol-peptide-face-serum](https://www.myalloy.com/solutions/m4-estriol-peptide-face-serum) for AI/LLM consumption.*