--- title: "Fix Crepey Eyelids: Prescription Estriol Eye Serum for Menopause" description: "This prescription-only eye cream combines 1% estriol and peptides to reduce wrinkles, firm skin, and boost hydration visibly." url: "https://www.myalloy.com/solutions/m4-estriol-peptide-eye-serum" --- # Fix Crepey Eyelids: Prescription Estriol Eye Serum for Menopause > This prescription-only eye cream combines 1% estriol and peptides to reduce wrinkles, firm skin, and boost hydration visibly. ## M4 Eye Cream Rx *3-month supply* Type: Prescription (Rx) Tags: Estriol , Peptides, Plant Based, Bioidentical Price: $90.00 Our prescription-only eye cream combines 1% estriol with wrinkle-fighting peptides to brighten, tighten, and transform the delicate eye area. The first of its kind–formulated by Alloy to deliver unmatched results for combatting the signs of aging. - Includes $0 unlimited doctor access - Delivered to your door for free - HSA/FSA Eligible Medically reviewed by: [Dr. Michelle Montville](https://www.myalloy.com/expert/michelle-montville), Prescribing Physician [Start Now](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&sku-ids%5B%5D=b90e510a-0137-4e08-ab57-d50c81ef1c9c&skip-category-select=true&type=intake) ## The results are in on M4 Eye Cream Rx In a 2025 independent clinical study, statistically significant improvements* seen in M4 Eye Cream Rx in a 12-week study include: ## 76% saw a less tired, less fatigued eye area ## 76% felt smoother skin with softer-looking wrinkles and crow's feet ## 74% saw a more even, brighter skin tone ## 74% agree skin felt more deeply hydrated ## Learn more about M4 Eye Cream Rx ### Details __What is it:__ A prescription-only, estrogen-based anti-aging formulation specifically created for the eye area. Active ingredient estriol increases collagen and elasticity, and peptides reduce fine lines, brighten eye area, and help prevent expression lines. Over 85% of users saw measurable improvement in deep hydration in 12 weeks, and 97% saw a 23% boost in skin hydration. __Who is it for:__ Women seeking to address signs of aging, as facial wrinkles increase in depth and number significantly after menopause, especially in the perioral and eye areas. __What am I getting:__ 1 bottle containing (3-month supply) of M4 Eye Cream Rx. __How to get it:__ Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you. ### Suggested Use Adding M4 Eye Cream Rx to your morning or nighttime skincare routine is easy, and it’s safe to use with your other skincare products. __Morning Routine__ 1. Start with a clean face 2. Apply 1 pump of M4 Eye Cream Rx to eye area 3. Follow with M4 Face Serum Rx, moisturizer, and SPF __Night Routine__ 1. Cleanse face 2. Apply 1 pump of M4 Eye Cream Rx 3. Follow with M4 Face Cream Rx, nighttime moisturizers, and retinoids (we suggest Alloy's Tretinoin Face Cream Rx) ### Safety Information - Suitable for all skin types, including sensitive skin. - Non-systemic: does not increase hormone levels in the blood. - Safe to use with Menopausal Hormone Therapy (MHT) and vaginal estrogen. - Discontinue if irritation occurs. - If you have a history of melasma, we recommend starting with a very small amount and increasing slowly. Discontinue if worsening melasma occurs. ### Ingredients Full list of ingredients: estriol 1%, palmitoyl pentapeptide-4 0.1%, acetyl hexapeptide-8 0.1%, C12-15 alkyl benzoate, caprylic/capric triglyceride, cetyl alcohol, ethylhexylglycerin, glycerin, glyceryl stearate, hydroxyethyl acrylate/sodium, acryloyldimethyl taurate copolymer, oleic Acid, olea europaea (olive) fruit oil, PEG-100 stearate, phenoxyethanol, dimethicone, polymethylsiloxane, water (aqua), stearic acid, trolamine, tocopheryl (vitamin E) acetate (provides antioxidant protection and helps strengthen the skin barrier). ![Woman smiling putting on eye cream](https://images.ctfassets.net/md0kv0ejg0xf/7MMbuvc76PVBntbOY2RMzw/c51a5f0e8e14a55b3f70b805cfdc9eec/Skin_Cream_Rectangle.png) *BRAVO @MYALLOY* ### "I'm 56 and have been using these products for a few months now and am blown away. My skin is soft and hydrated. Big fan. " - Susie via Instagram *THE M4 DIFFERENCE* ### The Original Estriol-Based Prescription Skincare Collection Alloy was the first to harness the power of estriol to combat the effects of hormone loss in your skin. Created by experts, trusted by doctors, and loved by women everywhere, the M4 collection is designed to work together. Each product is clinically proven to rebuild collagen, restore moisture, increase elasticity, and reduce wrinkles where you need it most. [View All Skincare](https://www.myalloy.com/skincare) ![M4 Bottles with Blocks](https://images.ctfassets.net/md0kv0ejg0xf/6XX0ZathjGTUSAip3l3MkH/13e32481df33a192b05142aa4e8c3016/BottleWithBlocks.png) ![Estriol Ingredient](https://images.ctfassets.net/md0kv0ejg0xf/4JpODwmdYBdEZxRXqMEr95/6c1196fd59f2349b1681dfd843fb8c44/Estriol__1_.png) *M4 Active Ingredient: Estriol* ### Estriol, a form of estrogen and the powerhouse ingredient in our M4 products, builds collagen, increases elasticity, and restores moisture. ## What our customers are saying: ## More about M4 Eye Serum - [The First (and Only) Eye Cream with Estriol](https://www.myalloy.com/blog/the-first-and-only-eye-cream-with-estriol) - [A Guide to Layering Skincare (and Adding M4 into Your Routine)](https://www.myalloy.com/blog/a-guide-to-layering-skincare-and-adding-m4-into-your-routine) ## Skin that feels like yours again Your skin isn't aging, it's changing. Estriol gives it exactly what it's been missing. [Get Started](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&skip-category-select=true&type=intake) ## Frequently asked questions ### Is M4 Eye Cream Rx right for me? Most women are good candidates. A doctor will confirm after a quick assessment. ### Can I use this with hormone therapy? Yes—M4 Eye Cream Rx is non-systemic and safe with HRT and vaginal estrogen. ### Do I need progesterone? No—because M4 is not systemic, progesterone is not required. ### Where is Alloy available? All 50 U.S. states and D.C. (Global users can still access our content & resources.) [Learn More](https://myalloy.zendesk.com/hc/en-us) ## The Alloy Promise At Alloy Health, we believe every woman deserves thoughtful, evidence-based care, and the information she needs to make confident decisions about her health based on facts, not fear. Our board-certified physicians follow guidelines from leading medical organizations including ACOG and The Menopause Society and recommend treatments tailored to each patient. ##### [Learn more](https://www.myalloy.com/who-we-are) ![The Alloy Promise - Small](https://images.ctfassets.net/md0kv0ejg0xf/1OxkVrKzucAIz3XjYr4dC7/a4d065b4ff812e2c000fbcd7568b4df0/Alloy_Promise.png) ### Disclosure *2025 Study: Based on a 12-week clinical study (n=34) using Corneometer®, Moisturemeter EpiD, Cutometer®, and Antera 3D® instrumental measurements, expert visual and tactile grading, and self-assessment questionnaire. --- *This is a markdown version of [https://www.myalloy.com/solutions/m4-estriol-peptide-eye-serum](https://www.myalloy.com/solutions/m4-estriol-peptide-eye-serum) for AI/LLM consumption.*