--- title: "Best Prescription Cream for Crepey Skin | M4 Estriol Body Treatment" description: "Restore aging skin with M4 Body Treatment Rx. Formulated with .2% Estriol and Peptides to clinically improve elasticity, firmness, and hydration. Targeted relief for menopause-related crepey skin. No systemic absorption. Prescribed by experts." url: "https://www.myalloy.com/solutions/m4-body-treatment-rx" --- # Best Prescription Cream for Crepey Skin | M4 Estriol Body Treatment > Restore aging skin with M4 Body Treatment Rx. Formulated with .2% Estriol and Peptides to clinically improve elasticity, firmness, and hydration. Targeted relief for menopause-related crepey skin. No systemic absorption. Prescribed by experts. ## M4® Body Treatment Rx *3-month supply* Type: Prescription (Rx) Tags: Estriol, Peptides, Plant Based, Bioidentical Price: $195.00 The only prescription estriol + peptide body treatment that delivers results in as little as 8 weeks. Clinically proven to instantly hydrate, visibly smooth, firm, and reduce crepiness where aging shows up most. It’s time to feel confident in your skin again. - Includes $0 unlimited doctor access - Delivered to your door for free - HSA/FSA Eligible [Start Now](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&sku-ids%5B%5D=14ad4b82-70a1-40e6-a8b8-17e64e49afee&skip-category-select=true&type=intake) ## The only Rx body treatment with estriol + peptides. ## Real women, real results. Clinically proven to firm, smooth, and reduce crepiness in a 2026 independent clinical study:* ## 97% agree skin felt more hydrated ## 95% felt smoother skin ## 84% saw firmer skin ## 79% saw improvement in crepiness ## Learn more about M4 Body Treatment Rx ### Details __What is it:__ A prescription-only, estriol-based anti-aging formula, combining 0.2% estriol in a peptide-rich base, backed by a triple-validated 12-week clinical study. It addresses the impact of hormonal decline on the body. Gentle, fragrance-free, and non-comedogenic. __Who is it for:__ For any woman experiencing visible skin changes like crepiness, dryness, and loss of firmness, particularly below the neck on the chest, legs, arms, hands or knees, due to estrogen loss in perimenopause or menopause. __What am I getting:__ 1 bottle (3-month supply) of M4 Body Treatment Rx. __How to get it:__ Prescription required. A menopause-specialized doctor will review your medical history to determine if this is the right treatment for you. ### Suggested Use Adding M4 Body Treatment Rx to your routine is easy and can be used with your other M4 & routine skincare products. One treatment per day, morning or night: - Cleanse body - Apply 1 full pump of M4 Body Treatment Rx to targeted area such as your chest, hands, legs above the knees or stomach. Allow it to absorb fully. - For a morning application, follow with moisturizer and SPF. For a night application, follow with moisturizer. ### Safety Information Always follow your physician’s instructions. M4 Skincare Rx Body is a topical estriol treatment and is non-systemic. It does not impact blood estrogen levels and does not require progesterone and can be used alongside HRT (Hormone Replacement Therapy), vaginal estrogen, and other M4 products. Consult your doctor before starting if you have any medical concerns. ### Ingredients __Active ingredients:__ Estriol 0.2% improves hydration and cell turnover, promotes collagen, addresses hormonal aging. __All Ingredients:__ Estriol 0.2%, Aqua, Glycerin, C12-15 Alkyl Benzoate, Glyceryl Stearate, PEG-100 Stearate, Stearic Acid, Oleic Acid, Olea Europaea (Olive) Fruit Oil, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Caprylic/Capric Triglycerides, Phenoxyethanol, Dimethicone, Cetyl Alcohol, Squalane, Polysorbate 60, Butylene Glycol, Pentylene Glycol, Triethanolamine, Tocopheryl Acetate, PEG-40 Hydrogenated Castor Oil, Hydroxyacetophenone, 1,2-Hexanediol, Palmitoyl Pentapeptide-4, Acetyl Hexapeptide-8, Ethylhexylglycerin. ![Woman in Swimsuit](https://images.ctfassets.net/md0kv0ejg0xf/2H3WFxLKRrYuvRRm7Nnej9/5cd0c6923608b60ff8be7cd26b114185/GettyImages-1125234724-4x3.jpg) *BRAVO @MYALLOY* ### "I'm 56 and have been using these products for a few months now and am blown away. My skin is soft and hydrated. Big fan. " - Susie via Instagram *THE M4 DIFFERENCE* ### The Original Estriol-Based Prescription Skincare Collection Alloy was the first to harness the power of estriol to combat the effects of hormone loss in your skin. Created by experts, trusted by doctors, and loved by women everywhere, the M4 collection is designed to work together. Each product is clinically proven to rebuild collagen, restore moisture, increase elasticity, and reduce wrinkles where you need it most. [View All Skincare](https://www.myalloy.com/skincare) ![M4 Bottles with Blocks](https://images.ctfassets.net/md0kv0ejg0xf/6XX0ZathjGTUSAip3l3MkH/13e32481df33a192b05142aa4e8c3016/BottleWithBlocks.png) ![Estriol Ingredient](https://images.ctfassets.net/md0kv0ejg0xf/4JpODwmdYBdEZxRXqMEr95/6c1196fd59f2349b1681dfd843fb8c44/Estriol__1_.png) *M4 Active Ingredient: Estriol* ### Estriol, a form of estrogen and the powerhouse ingredient in our M4 products, builds collagen, increases elasticity, and restores moisture. ## Real Alloy Customers. Real Results. ## Skin that feels like yours again Your skin isn't aging, it's changing. Estriol gives it exactly what it's been missing. [Get Started](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&skip-category-select=true&type=intake) ## Frequently asked questions ### Is M4 Body Treatment Rx right for me? Most women can use M4 Body Treatment Rx. Before your doctor prescribes M4 Body Treatment Rx, you’ll fill out a quick assessment, and they will review it to make sure it’s right for you. ### Can I use M4 Body Treatment Rx with hormone therapy? Yes. You can use M4 Body Treatment Rx with Menopausal Hormone Therapy (MHT) and vaginal estrogen, since it is not systemic and therefore not absorbed by your bloodstream. ### When should I start using the M4 Skincare line? M4 was made for women in perimenopause and menopause—the life stages when hormonal changes start to visibly affect the skin causing dryness, fine lines, and loss of radiance. Perimenopause typically begins in your 40s, though it can start as early as your mid-30s. By age 50, women can lose up to 50% of their total collagen compared to peak levels. If you’re in perimenopause, M4 is a smart way to get ahead of the curve. Topical estriol, the star ingredient in our formulas, helps keep skin resilient, youthful, and balanced—before signs of aging deepen. And if you’re already in menopause, M4 is designed to restore what hormonal shifts have taken away: firmness, hydration, and that healthy glow. ### What were the results of the clinical studies of M4 products? In three independent clinical studies (one on M4 Face Cream Rx in 2024 and one on M4 Eye Cream Rx in 2025 & M4 Body Treatment in 2026), results showed statistically significant improvements in hydration, elasticity, firmness, and overall skin health. Efficacy and safety results for these studies were verified by dermatology experts. __2024 Study to Assess the Facial Anti-Aging Efficacy of Topical Estriol and Estradiol__ Improvements seen in M4 Face Cream Rx with Estriol compared to placebo in 12 weeks include: 88% improvement in elasticity 70% improvement in hydration 68% improvement in overall skin health 57% improvement in skin texture __2025 Study to Evaluate the Efficacy of Estriol Eye Cream__ Improvements seen in M4 Eye Cream Rx in 12 weeks include: Up to 25% wrinkle reduction Up to 33% firmer looking skin* Up to 40% more elasticity* Up to 40% less crepiness on the eyelids* Immediately boosted hydration by 23%** __2026 Study to Evaluate the Efficacy of Estriol Body Cream__ Improvements seen in M4 Body Cream Rx on chest and legs in 12 weeks include: 18% improvement in skin hydration upon application 11% less crepiness on the chest 18% smoother skin texture on the chest 11% firmer looking skin on the chest and legs 7% improvement in skin elasticity *Based on Expert Assessment **Based on Instrumentation ### Do I need progesterone? No—because M4 is not systemic, progesterone is not required. ### Is M4 Rx eligible for HSA or FSA reimbursement? Yes! Medications prescribed by a licensed provider are eligible to be paid for or reimbursed by your HSA or FSA. Your invoice is available to download and include when you submit to your plan for reimbursement. If you require more information, please contact us at support@myalloy.com and we will assist you. Note: The IRS defines which medical expenses are eligible under an HSA or FSA and the products carried on Alloy are in compliance with these requirements. However, these plans can vary and some may not allow all eligible HSA or FSA expenses. It's important to always check with your benefits administrator to determine which expenses are eligible before you shop. ### Where is Alloy available? All 50 U.S. states and D.C. (Global users can still access our content & resources.) ## The Alloy Promise At Alloy Health, we believe every woman deserves thoughtful, evidence-based care, and the information she needs to make confident decisions about her health based on facts, not fear. Our board-certified physicians follow guidelines from leading medical organizations including ACOG and The Menopause Society and recommend treatments tailored to each patient. ##### [Learn more](https://www.myalloy.com/who-we-are) ![The Alloy Promise - Small](https://images.ctfassets.net/md0kv0ejg0xf/1OxkVrKzucAIz3XjYr4dC7/a4d065b4ff812e2c000fbcd7568b4df0/Alloy_Promise.png) ### Disclosure *Based on a 12-week clinical study (n=38) using Corneometer®, Moisturemeter EpiD, Cutometer®, and Antera 3D® instrumental measurements, expert visual and tactile grading, and self-assessment questionnaire. --- *This is a markdown version of [https://www.myalloy.com/solutions/m4-body-treatment-rx](https://www.myalloy.com/solutions/m4-body-treatment-rx) for AI/LLM consumption.*