--- title: "Save $30: The Prescription Estriol Duo for Hormonal Aging" description: "Achieve smoother, firmer skin with the M4 Face Cream Rx and Eye Cream Rx bundle for a complete skincare routine." url: "https://www.myalloy.com/solutions/daily-strength-duo" --- # Save $30: The Prescription Estriol Duo for Hormonal Aging > Achieve smoother, firmer skin with the M4 Face Cream Rx and Eye Cream Rx bundle for a complete skincare routine. ## Daily Strength Duo *3-month supply* Type: Prescription (Rx) Tags: Bundle and Save $30, Estriol, Peptides, Plant Based, Bioidentical Price: $210.00 (regularly $240.00) This high-performance pair delivers impressive results backed by clinical testing. M4 Face Cream Rx deeply hydrates mature skin, accelerates collagen production, and improves elasticity. M4 Eye Cream Rx combines 1% estriol with wrinkle-fighting peptides to hydrate, firm, and brighten the eye area. - Includes $0 unlimited doctor access - Delivered to your door for free - HSA and FSA Eligible [Start Now](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&sku-ids%5B%5D=d7fe4df5-7fd8-42c1-86d5-9be36bd6833c%2Cb90e510a-0137-4e08-ab57-d50c81ef1c9c&skip-category-select=true&type=intake) ## The results are in on M4 Eye Cream Rx In a 2025 independent clinical study, statistically significant improvements* seen in M4 Eye Cream Rx in a 12-week study include: - **25%** — improvement in wrinkle reduction - **33%** — improvement in firmness - **40%** — improvement in more elasticity - **40%** — improvement in crepiness on eyelids M4 Eye Cream Rx can be used with or without MHT because it does not impact blood estrogen levels. *Based on expert assessment ## Learn more about the Daily Strength Duo ### Details __What is it:__ Our exclusive Daily Strength Duo features two of our most popular prescription-strength skincare products: M4 Face Cream Rx and M4 Eye Cream Rx. Both contain estriol, proven to significantly improve (and even reverse) signs of aging. Our eye cream actually has a full 1% of estriol, boosting its wrinkle-fighting properties. __Who is it for:__ Women looking to fight signs of aging due to estrogen deficiency. __What am I getting:__ 1 bottle (45 grams) of M4 Face Cream Rx & 1 bottle (30 grams) of M4 Eye Cream Rx. This set contains a 3-month supply of each. __How to get it:__ Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you. ### Suggested Use __Personalize Your Routine __ For Morning or Nighttime: Step 1: Gently wash your face to remove dirt, oil, and makeup. Step 2: Apply 1 pump of M4 Eye Cream Rx around the entire eye area. Step 3: Apply toners/serums. Step 4: Apply 2 pump of M4 Face Cream Rx to face and neck, avoiding eye area. Follow with additional moisturizer if needed. __Morning:__ Follow with your SPF of choice. __Night:__ Follow with retinols, if you use them. We recommend our [Tretinoin Face Cream Rx](/solutions/tretinoin). __Heads up!__ If you're using your product for the first time, you may need to pump the bottle several times before the product starts to dispense. This is totally normal, sometimes it just takes a few pumps to get things flowing. Once it’s primed, you’re good to go! ### Safety Information - M4 products are suitable for all skin types including sensitive skin and are safe to use with your other skincare solutions. - They are also safe to use with Menopausal Hormone Therapy; a clinical study found that there is no increase in estriol levels in the blood after using M4. - We recommend performing a “patch test” for a few days by applying a small amount to one area of your face or neck. - Discontinue if irritation occurs. - If you have a history of melasma, we recommend starting with a very small amount and increasing slowly. Discontinue if worsening melasma occurs. ### Estriol Is a Game-changer Prescription-strength topical estriol has been proven to significantly improve (and even reverse) signs of aging. Estriol promotes collagen production, hydrates deeply, and strengthens the skin’s structure for younger-looking, more radiant skin. ### Real Customers Love It In a 2025 survey, 92% of Alloy’s M4 Face Cream Rx users said they’d recommend it to a friend because it delivered real results they could see. ### Designed for Flexibility Every face is different, and every M4 skincare product can be used to suit your needs—as part of your morning or evening routine—and can include our Tretinoin Face Cream Rx. ![Woman smiling putting on eye cream](https://images.ctfassets.net/md0kv0ejg0xf/7MMbuvc76PVBntbOY2RMzw/c51a5f0e8e14a55b3f70b805cfdc9eec/Skin_Cream_Rectangle.png) *DID YOU KNOW?* ### Up to 30% of your dermal collagen is lost in the first 5 years of menopause, with another 2.1% lost every year after. ![Estriol Ingredient](https://images.ctfassets.net/md0kv0ejg0xf/4JpODwmdYBdEZxRXqMEr95/6c1196fd59f2349b1681dfd843fb8c44/Estriol__1_.png) *KEY M4 SKINCARE INGREDIENT: ESTRIOL* ### What is Estriol? Estriol is one of three forms of estrogen our bodies naturally produce, until menopause. Once we hit menopause, we lose up to 30% of our dermal collagen in the first five years alone. And it only goes down from there. The solution to losing estrogen is replenishing it, and that's where estriol comes in. Research shows that topical estriol can address hormonal aging and helps keep skin resilient, youthful, and balanced. Topical estriol stays on the surface of your skin and doesn’t enter your bloodstream, making it safe for everyday use. [Get Skincare Rx](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&skip-category-select=true&type=intake) ### How Alloy Works We make it easy to connect directly with a menopause-specialized physician. [Find Your Plan](https://secure.myalloy.com/experience) **Tell Us About Yourself (5-10 minutes)** Fill out an intake form to share your symptoms, health history, and goals **Get a Treatment Plan (less than 12 hours)** Your expert doctor will create a personalized plan based on your needs. **Free Delivery to Your Door** Get your prescriptions sent right to your home with free shipping **24/7 Care + Ongoing Support** Get unlimited access to your doctor, support groups, and more ## Frequently asked questions ### Are the M4 products right for me? Most women are good candidates. A doctor will confirm after a quick assessment. ### Can I use them with hormone therapy? Yes—all M4 products are non-systemic and safe with MHT and vaginal estrogen. ### When should I start using the M4 Skincare line? M4 was made for women in perimenopause and menopause—the life stages when hormonal changes start to visibly affect the skin causing dryness, fine lines, and loss of radiance. Perimenopause typically begins in your 40s, though it can start as early as your mid-30s. By age 50, women can lose up to 50% of their total collagen compared to peak levels. If you’re in perimenopause, M4 is a smart way to get ahead of the curve. Topical estriol, the star ingredient in our formulas, helps keep skin resilient, youthful, and balanced—before signs of aging deepen. And if you’re already in menopause, M4 is designed to restore what hormonal shifts have taken away: firmness, hydration, and that healthy glow. ### Where is Alloy available? All 50 U.S. states and D.C. (Global users can still access our content & resources.) [Learn More](https://myalloy.zendesk.com/hc/en-us) ## What our customers are saying: ### The Alloy Promise At Alloy Health, we believe every woman deserves thoughtful, evidence-based care, and the information she needs to make confident decisions about her health based on facts, not fear. Our board-certified physicians follow guidelines from leading medical organizations including ACOG and The Menopause Society and recommend treatments tailored to each patient. [Learn more](https://www.myalloy.com/compounded-products) ![The Alloy Promise](https://images.ctfassets.net/md0kv0ejg0xf/5S3J54W7j0MPpyLNbGg2WF/96e117713fd5bd6ddfc07bb92e5b73e6/Group_80197.png) --- *This is a markdown version of [https://www.myalloy.com/solutions/daily-strength-duo](https://www.myalloy.com/solutions/daily-strength-duo) for AI/LLM consumption.*