--- title: "Advanced Essentials Set | Hydrating Serum & Eye Cream" description: "Save $30 on this powerful anti-aging duo with prescription-strength estriol, peptides, and hyaluronic acid. Clinically proven to smooth fine lines & rejuvenate skin." url: "https://www.myalloy.com/solutions/advanced-essentials" --- # Advanced Essentials Set | Hydrating Serum & Eye Cream > Save $30 on this powerful anti-aging duo with prescription-strength estriol, peptides, and hyaluronic acid. Clinically proven to smooth fine lines & rejuvenate skin. ## Advanced Essentials Set *3 month supply* Type: Prescription (Rx) Tags: M4 Face Serum Rx, M4 Eye Cream Rx, $249 Value Price: $219.00 This powerful duo—M4 Face Serum Rx and M4 Eye Cream Rx—combines prescription-strength estriol, peptides, and hyaluronic acid to hydrate, firm, and visibly rejuvenate skin. Together, they boost collagen and elasticity, smooth fine lines, brighten, and support hormonal skin repair for healthier, more youthful-looking skin. - Delivered to your door for free - Includes unlimited messaging with Alloy's menopause-expert doctors __SAVE $30 WITH THE ADVANCED ESSENTIALS SET__ Purchase both M4 Face Serum Rx and M4 Eye Cream Rx and save. [Start Now](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&sku-ids%5B%5D=6ce042dd-5869-490f-b12e-126781cb0aa2%2Cb90e510a-0137-4e08-ab57-d50c81ef1c9c&skip-category-select=true&type=intake) ## The results are in on M4 Eye Cream Rx In a 2025 independent clinical study, statistically significant improvements* seen in M4 Eye Cream Rx in a 12-week study include: - **25%** — improvement in wrinkle reduction - **33%** — improvement in firmness - **40%** — improvement in more elasticity - **40%** — improvement in crepiness on eyelids M4 Eye Cream Rx can be used with or without MHT because it does not impact blood estrogen levels. *Based on expert assessment ## Learn more about the Advanced Essentials Set ### Details __What is it:__ The Advanced Essentials Set includes M4 Face Serum Rx and M4 Eye Cream Rx, our new powerful estrogen-based innovations. You’ll save $30 when you buy them together. __Who is it for:__ Women looking to fight signs of aging due to estrogen deficiency __What am I getting:__ 1 bottle (45 grams) M4 Face Serum Rx and 1 bottle (15 grams) M4 Eye Cream Rx. This set contains a 3-month supply of each. __How to get it:__ Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you. ### Suggested Use Step 1: Cleanse face Step 2: Apply 1 pump of M4 Eye Cream Rx around the entire eye area. Use morning and/or night. Step 3: Apply 2 pumps of M4 Face Serum Rx to face and neck, avoiding eye area. Morning: Start with moisturizer and follow with your SPF of choice Night: Start with moisturizer and follow with and any retinols if you use them (we recommend our [Tretinoin Face Cream Rx](/solutions/tretinoin)) __Heads up!__ If you're using your product for the first time, you may need to pump the bottle several times before the product starts to dispense. This is totally normal, sometimes it just takes a few pumps to get things flowing. Once it’s primed, you’re good to go! ### Safety Information - M4 products are suitable for all skin types including sensitive skin and are safe to use with your other skincare solutions. - They are also safe to use with Menopausal Hormone Therapy; a clinical study found that there is no increase in estriol levels in the blood after using M4. - We recommend performing a “patch test” for a few days by applying a small amount to one area of your face or neck. - Discontinue if irritation occurs. - If you have a history of melasma, we recommend starting with a very small amount and increasing slowly. Discontinue if worsening melasma occurs. ### Estriol Is a Game-changer Prescription-strength topical estriol has been proven to significantly improve (and even reverse) signs of aging. Estriol promotes collagen production, hydrates deeply, and strengthens the skin’s structure for younger-looking, more radiant skin. ### Real Women Love It 76% of women who tried Alloy’s M4 Eye Cream Rx found their skin looked smoother and the product softened the look of wrinkles and crow’s feet. ### Designed for Flexibility Every face is different, and every M4 skincare product can be used to suit your needs—as part of your morning or evening routine—and can include our Tretinoin Face Cream Rx. ![Woman smiling putting on eye cream](https://images.ctfassets.net/md0kv0ejg0xf/7MMbuvc76PVBntbOY2RMzw/c51a5f0e8e14a55b3f70b805cfdc9eec/Skin_Cream_Rectangle.png) *DID YOU KNOW?* ### Up to 30% of your dermal collagen is lost in the first 5 years of menopause, with another 2.1% lost every year after. ![Estriol Ingredient](https://images.ctfassets.net/md0kv0ejg0xf/4JpODwmdYBdEZxRXqMEr95/6c1196fd59f2349b1681dfd843fb8c44/Estriol__1_.png) *KEY M4 SKINCARE INGREDIENT: ESTRIOL* ### What is Estriol? Estriol is one of three forms of estrogen our bodies naturally produce, until menopause. Once we hit menopause, we lose up to 30% of our dermal collagen in the first five years alone. And it only goes down from there. The solution to losing estrogen is replenishing it, and that's where estriol comes in. Research shows that topical estriol can address hormonal aging and helps keep skin resilient, youthful, and balanced. Topical estriol stays on the surface of your skin and doesn’t enter your bloodstream, making it safe for everyday use. [Get Skincare Rx](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&skip-category-select=true&type=intake) ### How Alloy Works We make it easy to connect directly with a menopause-specialized physician. [Find Your Plan](https://secure.myalloy.com/experience) **Tell Us About Yourself (5-10 minutes)** Fill out an intake form to share your symptoms, health history, and goals **Get a Treatment Plan (less than 12 hours)** Your expert doctor will create a personalized plan based on your needs. **Free Delivery to Your Door** Get your prescriptions sent right to your home with free shipping **24/7 Care + Ongoing Support** Get unlimited access to your doctor, support groups, and more ## Frequently asked questions ### Are the M4 products right for me? Most women are good candidates. A doctor will confirm after a quick assessment. ### Can I use them with hormone therapy? Yes—all M4 products are non-systemic and safe with MHT and vaginal estrogen. ### Do I need progesterone? No—because M4 is not systemic, progesterone is not required. ### Where is Alloy available? All 50 U.S. states and D.C. (Global users can still access our content & resources.) [Learn More](https://myalloy.zendesk.com/hc/en-us) ## What our customers are saying: ### The Alloy Promise At Alloy Health, we believe every woman deserves thoughtful, evidence-based care, and the information she needs to make confident decisions about her health based on facts, not fear. Our board-certified physicians follow guidelines from leading medical organizations including ACOG and The Menopause Society and recommend treatments tailored to each patient. [Learn more](https://www.myalloy.com/compounded-products) ![The Alloy Promise](https://images.ctfassets.net/md0kv0ejg0xf/5S3J54W7j0MPpyLNbGg2WF/96e117713fd5bd6ddfc07bb92e5b73e6/Group_80197.png) --- *This is a markdown version of [https://www.myalloy.com/solutions/advanced-essentials](https://www.myalloy.com/solutions/advanced-essentials) for AI/LLM consumption.*