We've helped thousands find relief!

Meet Your Simple,

Science-Backed Skincare Routine

$209.97 for a 3-month supply of M4 Face Cream (45ml) and a 3-month supply of Tretinoin Face Cream (30ml). That's $30 in savings when you bundle!

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How it works:

The duo you never knew you needed!

M4 Face Cream: $149.97

Is our custom-blended estriol moisturizing cream which works to increase collagen production and address signs of aging.

Tretinoin Face Cream: $90

Is a topical treatment for acne, fine lines, hyperpigmentation, and discoloration. It works by speeding up cell turnover, which gives your skin a more youthful look and feel.

M4 + Tretinoin: $209.97 (save $30!)

It’s the perfect one-two combo to keep you glowing from the inside out!

Who is it for?

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Our skincare solutions are for anyone looking to reverse the effects of estrogen-deficiency in the skin due to menopause, perimenopause, or just aging (loss of collagen, decreased elasticity and moisture, and appearance of wrinkles), and for those looking to treat acne, fine lines, hyperpigmentation, and discoloration. We formulated M4 Face Cream and Tretinoin Face Cream with women just like us in mind!

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Science-backed ingredients:

M4:

Learn about the key ingredients in M4 Face Cream.

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Estriol:

Increases collagen production, retains and restores skin moisture, increases skin firmness, decreases pore size, decreases wrinkle depth, and increases skin elasticity.

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Glycerin:

Attracts moisture and locks it into the top layer of the skin, leaving it more hydrated.

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Vitamin E:

Stops skin from losing moisture, protects cells from UV damage, and helps soften skin.

Tretinoin:

Learn about the key ingredients in Tretinoin Face Cream.

Tretinoin

Tretinoin:

Speeds up cell turnover.

Niacinamide

Niacinamide:

Reduces the appearance of blemishes and brightens your overall skin tone.

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Aloe:

Helps moisturize and soothe your skin.

The routine:

  • Adding M4 to your morning or nighttime skincare routine is easy. You can replace your current moisturizer and firming creams with M4 or add it to your regime. Just apply one pump of M4 to the face and neck.
  • Follow it up with Tretinoin: Apply a pea-sized amount (about ½ pump) using your fingers to your forehead, cheeks, and chin, avoiding your eyelids and the corners around your mouth and nose. Start by using every other night, and after a few weeks of use, increase to nightly as your skin tolerates it.
  • Remember to always complete your morning routine with an SPF!

By the numbers:

Aging skin

Did you know that up to 30% of dermal collagen is lost during the first 5 years of menopause? It decreases by an additional 2.1% every year after. And, did you know that tretinoin provides epidermal thickening by up to 30%?

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Aging skin

Ready to get M4 and Tretinoin?

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Ready to improve skin texture and appearance?

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Related Research:

Gehring, W. “Nicotinic Acid/Niacinamide and the Skin.” Journal of Cosmetic Dermatology, vol. 3, no. 2, Apr. 2004, pp. 88–93, https://doi.org/10.1111/j.1473-2130.2004.00115.x.

Griffiths, Christopher E. M. “Two Concentrations of Topical Tretinoin (Retinoic Acid) Cause Similar Improvement of Photoaging but Different Degrees of Irritation.” Archives of Dermatology, vol. 131, no. 9, 1 Sept. 1995, p. 1037, https://doi.org/10.1001/archderm.1995.01690210067011.

Hajheydari, Z., et al. “Effect of Aloe Vera Topical Gel Combined with Tretinoin in Treatment of Mild and Moderate Acne Vulgaris: A Randomized, Double-Blind, Prospective Trial.” Journal of Dermatological Treatment, 2014, www.semanticscholar.org/paper/Effect-of-Aloe-vera-topical-gel-combined-with-in-of-Hajheydari-Saeedi/2e3494d168ab7cb6428c8633ca920e1d7b06afb5.

Lephart ED, Naftolin F. Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin. Dermatol Ther (Heidelb). 2021 Feb;11(1):53-69. doi: 10.1007/s13555-020-00468-7. Epub 2020 Nov 26. PMID: 33242128; PMCID: PMC7859014.

Rzepecki AK, Murase JE, Juran R, Fabi SG, McLellan BN. Estrogen-deficient skin: The role of topical therapy. Int J Womens Dermatol. 2019 Mar 15;5(2):85-90. doi: 10.1016/j.ijwd.2019.01.001. PMID: 30997378; PMCID: PMC6451761.

Sitohang, Irma Bernadette S., et al. “Topical Tretinoin for Treating Photoaging: A Systematic Review of Randomized Controlled Trials.” International Journal of Women’s Dermatology, vol. 8, no. 1, Mar. 2022, p. e003, https://doi.org/10.1097/jw9.0000000000000003.

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