---
title: "Topical Facial Estrogen with Systemic Hormone Therapy"
description: "Can topical facial estriol be used with systemic hormone therapy? Learn how local estrogen on the face stays local and may be used safely."
url: "https://www.myalloy.com/knowledge-base/topical-facial-estrogen-with-systemic-hormone-therapy"
---

# Topical Facial Estrogen with Systemic Hormone Therapy

> Can topical facial estriol be used with systemic hormone therapy? Learn how local estrogen on the face stays local and may be used safely.

## Can topical facial estrogen be used alongside systemic hormone therapy safely?

Yes, you can safely use topical facial estrogen alongside systemic hormone therapy. Here at Alloy, we lean on both the science and decades of experience with local estrogens, and everything points in the same direction: topical estriol used on the face doesn’t raise systemic estrogen levels.

Studies show that low dose topical estriol behaves the same way topical vaginal estrogen does, meaning it stays local to the skin and does not increase serum estrogen levels. Our M4 face cream was designed with that in mind, and you can use it on its own or together with systemic MHT. You can take a look at M4 here if you want to see the details of the formulation or the clinical study results: [M4 Estriol Face Cream](https://www.myalloy.com/solutions/m4).


**M4 Face Cream Rx**

Estriol

Restore elasticity, hydrate deeply and build collagen—this powerful estriol-enriched face cream does it all

[Start Now](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&sku-ids%5B%5D=d7fe4df5-7fd8-42c1-86d5-9be36bd6833c&skip-category-select=true&type=intake)

If you’d like to hear it explained by our medical experts, the topical estrogen safety chapter from our webinar breaks it down clearly. You can watch it here: [Topical Estrogen Safety](https://www.youtube.com/watch?v=voedsMd4Zsc&t=2345s).


[Watch video](https://www.youtube.com/watch?v=voedsMd4Zsc&t=2345s)

The short version is that systemic hormones travel through your bloodstream to many tissues, while topical estriol works right in the skin where you put it, so the two don’t interfere with each other.

[Find Your Plan](https://secure.myalloy.com/experience)

---

This answer was created using the following resources:

- [A New Approach to Aging with Alloy - Topical Estrogen Safety](https://www.youtube.com/watch?v=voedsMd4Zsc)
- [The Science Behind Topical Estrogen: Doctors Review M4 Cream](https://www.youtube.com/watch?v=ss6SwpqS1vA)
- [Pelvic Power:What Every Woman Should Know | Dr. Sara Reardon - Safety and Alternatives for Topical Estrogen](https://www.youtube.com/watch?v=jihMIubXXfc)
- [Topical Estrogen's Role in Healthy, Radiant Skin | Dr. Ellen Gendler & Dr. Corinne Menn - Research & Safety of Topical Estrogen](https://www.youtube.com/watch?v=kOzPrwnwsFA)
- [Skin Deep with Dr. Menn: Let's Talk Skincare & Estrogen | Dr. Corinne Menn - Systemic vs. Topical Estrogen](https://www.youtube.com/watch?v=sW48U6HSkcc)
- [Breast Health & Hormone Therapy | Dr. Corinne Menn - Vaginal Estrogen with Systemic MHT](https://www.youtube.com/watch?v=4Ld2932ZM6o)
- [Why Your Skin Changes During Midlife and What to Do About It - Hormone Therapy and Topical Estrogens](https://www.youtube.com/watch?v=LeElXm4cMO0)
- [Hot in Here: Let’s Talk About Sex & Menopause | Dr. Rachel Rubin - Combining Vaginal and Systemic Estrogen](https://www.youtube.com/watch?v=N8rPEMccEwM)
- [The Science Behind Putting Estrogen On Your Face](https://www.myalloy.com/blog/the-science-behind-putting-estrogen-on-your-face)
- [Topical Estrogen: Tips from Dr. Ellen Gendler](https://www.myalloy.com/blog/why-topical-estrogen-should-be-part-of-your-skincare)
- [Estrogen Therapy: Biohacking for Women](https://www.myalloy.com/blog/estrogen-the-powerful-longevity-biohack-hiding-in-plain-sight)
- [Skincare Routine | M4](https://www.myalloy.com/blog/why-estrogen-belongs-in-your-skincare-routine-and-not-just-in-your-hormone)
- [HRT After Breast Cancer | When Can I Start? Guidelines - Alloy](https://www.myalloy.com/blog/when-is-it-reasonable-to-consider-starting-hrt-after-breast-cancer)
- [Collagen & Estrogen: How Are They Connected?](https://www.myalloy.com/blog/what-women-need-to-know-about-the-link-between-collagen-and-estrogen)

---

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