---
title: "Targeted Facial Skin Option Without Systemic Hormone Therapy | Alloy Health Knowledge Base"
description: "Learn how low-dose topical estriol for the face can target estrogen-related skin changes like dryness and loss of firmness without systemic hormone therapy."
url: "https://www.myalloy.com/knowledge-base/targeted-facial-skin-option-without-systemic-hormone-therapy"
---

# Targeted Facial Skin Option Without Systemic Hormone Therapy | Alloy Health Knowledge Base

> Learn how low-dose topical estriol for the face can target estrogen-related skin changes like dryness and loss of firmness without systemic hormone therapy.

## What targeted option exists for facial skin changes if systemic hormone therapy isn’t the goal?

A targeted option is low-dose topical estriol for the face, rather than systemic hormone therapy. Here at Alloy, that’s [M4 Face Cream Rx](https://www.myalloy.com/solutions/m4), which is meant to help with estrogen-related skin changes like dryness, thinning, loss of firmness, reduced elasticity, and texture changes.


**M4 Face Cream Rx**

Estriol

Restore elasticity, hydrate deeply and build collagen—this powerful estriol-enriched face cream does it all

[Start Now](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&sku-ids%5B%5D=d7fe4df5-7fd8-42c1-86d5-9be36bd6833c&skip-category-select=true&type=intake)

It can be used on its own, even if you’re not taking MHT. Our clinical information notes that topical facial estriol does not increase systemic estrogen levels, so it’s a local skin-focused option. If you want the science behind it, this [short article](https://www.myalloy.com/blog/the-science-behind-putting-estrogen-on-your-face) and this [video chapter on systemic vs. topical estrogen](https://www.youtube.com/watch?v=sW48U6HSkcc&t=572s) explain it clearly.


[Watch video](https://www.youtube.com/watch?v=sW48U6HSkcc&t=572s)

[Find Your Plan](https://secure.myalloy.com/experience)

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This answer was created using the following resources:

- [Skin Deep with Dr. Menn: Let's Talk Skincare & Estrogen | Dr. Corinne Menn - Systemic vs. Topical Estrogen](https://www.youtube.com/watch?v=sW48U6HSkcc)
- [Why Your Skin Changes During Midlife and What to Do About It - Hormone Therapy and Topical Estrogens](https://www.youtube.com/watch?v=LeElXm4cMO0)
- [Skincare Routine | M4](https://www.myalloy.com/blog/why-estrogen-belongs-in-your-skincare-routine-and-not-just-in-your-hormone)
- [The Science Behind Putting Estrogen On Your Face](https://www.myalloy.com/blog/the-science-behind-putting-estrogen-on-your-face)
- [Topical Estrogen: Tips from Dr. Ellen Gendler](https://www.myalloy.com/blog/why-topical-estrogen-should-be-part-of-your-skincare)
- [Perimenopause Skin Issues: Easy Solutions for Glowing Skin](https://www.myalloy.com/blog/expert-tips-for-menopause-skin-care-during-perimenopause-and-menopause)

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