--- title: "In which situations is transdermal estrogen generally preferable" description: "Discover when transdermal estrogen is preferable, especially to reduce blood clot risk in menopause hormone therapy. Learn about patches, gels, and sprays." url: "https://www.myalloy.com/knowledge-base/in-which-situations-is-transdermal-estrogen-generally-preferable" --- # In which situations is transdermal estrogen generally preferable > Discover when transdermal estrogen is preferable, especially to reduce blood clot risk in menopause hormone therapy. Learn about patches, gels, and sprays. ## In which situations is transdermal estrogen generally preferable? Transdermal estrogen (such as patches, gels, or sprays) is generally preferable in certain situations, especially when minimizing the risk of blood clots is important. Here at Alloy, we recommend considering transdermal options if you: - Have high blood pressure - Are sedentary - Have Type-2 Diabetes or are at high risk for developing it - Have a strong family history of heart attack, stroke, or blood clotting disorders - Are over 70, are starting Menopausal Hormone Therapy (MHT) after age 60, or are starting MHT more than 10 years after your last period - Smoke, as this increases your baseline risk for blood clots Transdermal estrogen is absorbed through the skin and bypasses the liver, so it does not activate clotting factors, making it a safer choice for those with increased clotting risk. It also provides more stable hormone levels, which can be especially helpful for people who are sensitive to fluctuations, such as those who experience migraines. If you want to learn more about the different forms of estrogen therapy and which might be right for you, check out our detailed guide: [Estradiol Patch vs. Pill vs. Spray: What’s right for me?](https://www.myalloy.com/blog/estradiol-patch-vs-pill-vs-spray-whats-right-for-me) You can also explore our transdermal options: - [Estradiol Patch](https://www.myalloy.com/solutions/estradiol-patch) **Estradiol Patch** 1-month supply Best for a low-maintenance routine, estrogen is abosorbed through your skin. [Start Now](https://secure.myalloy.com/experience?categories%5B%5D=mht&sku-ids%5B%5D=942fc36f-61c5-4cb9-ba30-8024ba2beb0a&skip-category-select=true&type=intake) - [Evamist® Estradiol Spray](https://www.myalloy.com/solutions/evamist) **Evamist® Estradiol Spray** 1-month supply Best for those who prefer to use a spray instead of a patch or gel [Start Now](https://secure.myalloy.com/experience?categories%5B%5D=mht&sku-ids%5B%5D=942fc36f-61c5-4cb9-ba30-8024ba2beb0a&skip-category-select=true&type=intake) - [Estradiol Gel](https://www.myalloy.com/solutions/divigel-estradiol-gel) **Estradiol Gel** 1-month supply Best for those who prefer a daily gel application [Start Now](https://secure.myalloy.com/experience?categories%5B%5D=mht&sku-ids%5B%5D=942fc36f-61c5-4cb9-ba30-8024ba2beb0a&skip-category-select=true&type=intake) For a helpful video explanation, watch the "Special Considerations" chapter in Dr. Sharon Malone's YouTube video, which covers when transdermal estrogen is preferable. [Watch the relevant chapter here.](https://www.youtube.com/watch?v=Djcl6PKc7mU&t=0s) [Watch video](https://www.youtube.com/watch?v=Djcl6PKc7mU) If you’re unsure which option is best for you, start with our quick [online assessment](https://secure.myalloy.com/experience) and connect with a menopause-trained Alloy doctor for personalized recommendations. [Find Your Plan](https://secure.myalloy.com/experience) --- This answer was created using the following resources: - [Estradiol Patch](https://www.myalloy.com/solutions/estradiol-patch) - [Evamist® Estradiol Spray](https://www.myalloy.com/solutions/evamist) - [Estradiol Gel](https://www.myalloy.com/solutions/divigel-estradiol-gel) - [Estradiol Vaginal Cream](https://www.myalloy.com/solutions/estradiol-vaginal-cream) - [Low-Dose Birth Control Pill](https://www.myalloy.com/solutions/low-dose-birth-control-pill) - [How to Choose the Right Menopausal Hormone Therapy for You | Dr. Sharon Malone - Special Considerations](https://www.youtube.com/watch?v=Djcl6PKc7mU) - [Hormone Therapy 101 (pt.3) | Dr. Corinne Menn - Transdermal vs. Oral Estrogen Options](https://www.youtube.com/watch?v=7yS2B_Oakbo) - [Understanding Hormones During Menopause | Dr. Mary Jane Minkin - Stable Hormone Levels and Personal Preferences](https://www.youtube.com/watch?v=_tZRmRCnti4) - [Catching Up With Dr. Corinne Menn | Alloy](https://www.myalloy.com/blog/hormone-therapy-101-with-dr-corinne-menn) - [Estradiol Patch vs. Pill vs. Spray: What's right for me?](https://www.myalloy.com/blog/estradiol-patch-vs-pill-vs-spray-whats-right-for-me) - [What Is Estradiol?](https://www.myalloy.com/blog/what-is-estradiol) - [Estradiol Cream or Patches? Find the Best Option for You](https://www.myalloy.com/blog/estradiol-cream-vs-estradiol-patches-whats-the-difference-and-which-should) --- *This is a markdown version of [https://www.myalloy.com/knowledge-base/in-which-situations-is-transdermal-estrogen-generally-preferable](https://www.myalloy.com/knowledge-base/in-which-situations-is-transdermal-estrogen-generally-preferable) for AI/LLM consumption.*