---
title: "Weight Loss Outcomes at 5%, 10%, 15%, 20% Thresholds"
description: "Discover how combining GLP-1 therapy with menopausal hormone therapy improves clinically meaningful weight loss at 5%, 10%, 15%, and 20% thresholds."
url: "https://www.myalloy.com/knowledge-base/how-did-weight-loss-outcomes-differ-when-evaluating-clinically-meaningful-thresholds-like-5-10-15-an"
---

# Weight Loss Outcomes at 5%, 10%, 15%, 20% Thresholds

> Discover how combining GLP-1 therapy with menopausal hormone therapy improves clinically meaningful weight loss at 5%, 10%, 15%, and 20% thresholds.

## How did weight-loss outcomes differ when evaluating clinically meaningful thresholds like 5%, 10%, 15%, and 20% of total body weight?

When researchers looked at **clinically meaningful weight loss thresholds** of 5%, 10%, 15%, and 20% of total body weight, the differences were clear.

In the study comparing women on GLP-1 medications alone versus those using GLP-1s plus menopausal hormone therapy, the group using both treatments consistently had higher success rates at every threshold:

- A greater percentage achieved at least 5% weight loss
- More reached 10%
- More reached 15%
- And more achieved 20% total body weight loss

This pattern held across multiple time points, including 3, 6, 9, and 12 months. In other words, women using GLP-1s together with hormone therapy were more likely to reach higher levels of total body weight reduction.

You can see the breakdown visually in this section of our video: [GLP-1s + MHT: A Power Combo for Weight Loss? - Study Results: Weight Loss Comparison](https://www.youtube.com/watch?v=PVFjrKs1Kog&t=16s)


[Watch video](https://www.youtube.com/watch?v=PVFjrKs1Kog&t=16s)

At Alloy, this is why we offer a holistic Weight Care program that includes both GLP-1 medications and MHT when appropriate. The combination has been shown to produce about 30% greater weight loss after 12 months compared to GLP-1 use alone. If you’d like to learn more about how we approach this combination, you can explore our program here: [Start Your Weight Care Journey with Alloy](https://www.myalloy.com/weight)

[Find Your Plan](https://secure.myalloy.com/experience)

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This answer was created using the following resources:

- [GLP-1s + MHT: A Power Combo for Weight Loss? - Study Results: Weight Loss Comparison](https://www.youtube.com/watch?v=PVFjrKs1Kog)
- [How GLP-1s Support Weight Loss & Metabolic Health](https://www.myalloy.com/blog/how-do-glp-1s-work)
- [GLP-1 and Menopausal Hormone Therapy: A Powerful Combination](https://www.myalloy.com/blog/why-glp-1s-and-mht-are-a-beneficial-combination)
- [Start Your Weight Care Journey with Alloy](https://www.myalloy.com/blog/starting-your-weight-care-journey)
- [Tips on How Healthy Habits Boost Weight Loss](https://www.myalloy.com/blog/healthy-habits-boost-weight-loss)

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