---
title: "Evidence for M4 Estreal Face Cream in Menopausal Skin"
description: "See the clinical evidence for M4 Estriol Face Cream: a 12-week study showing improved hydration, elasticity, texture, and skin firmness in menopause."
url: "https://www.myalloy.com/knowledge-base/evidence-for-m4-estreal-face-cream-in-menopausal-skin"
---

# Evidence for M4 Estreal Face Cream in Menopausal Skin

> See the clinical evidence for M4 Estriol Face Cream: a 12-week study showing improved hydration, elasticity, texture, and skin firmness in menopause.

## What evidence supports the use of M4 Estreal face cream for menopausal skin changes?

Here at Alloy, we leaned heavily on clinical testing to make sure M4 Face Cream Rx wasn’t just a nice idea on paper but something that truly helps with menopausal skin changes. The strongest evidence comes from an independent 12 week double blind placebo controlled study, which is the gold standard for testing skincare.

In that study, women using M4 saw measurable improvements that directly relate to the kinds of estrogen driven skin changes that show up during perimenopause and menopause, things like dryness, fine lines, dullness, and a loss of firmness. The results included an 88 percent improvement in elasticity, a 70 percent increase in hydration, a 68 percent improvement in overall skin health, and a 57 percent improvement in skin texture. Importantly, there were no increases in blood estrogen levels, so the estriol stays local to the skin rather than affecting the rest of the body.

If you want to hear these findings discussed, the chapter on the M4 study in this video walks through the data in a very clear way: [M4 Estriol Face Cream Study Results](https://www.youtube.com/watch?v=GQhZJVD6w2o&t=4425s).


[Watch video](https://www.youtube.com/watch?v=GQhZJVD6w2o&t=4425s)

You can also read the full clinical report for all the details about the study design and measurements, which you’ll find here: [M4 Clinical Study](https://assets.ctfassets.net/md0kv0ejg0xf/4gaULAkbHbgNZtNMOgg1PI/91329de08abacf438fb83d99e756ee99/Alloy_M4_Report_063024.pdf).

If you want to take a closer look at the product itself, you can find everything on the M4 Face Cream page: [M4 Face Cream Rx](https://www.myalloy.com/solutions/m4).


**M4 Face Cream Rx**

Estriol

Restore elasticity, hydrate deeply and build collagen—this powerful estriol-enriched face cream does it all

[Start Now](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&sku-ids%5B%5D=d7fe4df5-7fd8-42c1-86d5-9be36bd6833c&skip-category-select=true&type=intake)

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This answer was created using the following resources:

- [Hormones: They're More Than Just Hot Flashes! | Dr. Darwana Ratleff Todd - M4 Estriol Face Cream Study Results](https://www.youtube.com/watch?v=GQhZJVD6w2o)
- [Thank you so much Dr. Mary Claire Haver for sharing your updated routine! - Benefits of Alloys M4 Face Cream](https://www.youtube.com/watch?v=NvtVIfs8McQ)
- [Why Your Skin Changes During Midlife and What to Do About It - Hormone Therapy and Topical Estrogens](https://www.youtube.com/watch?v=LeElXm4cMO0)
- [Why Your Skin Changes in Perimenopause and Menopause - Addressing the Estrogen Gap in Skincare](https://www.youtube.com/watch?v=-muvssSSReM)
- [Perimenopause Skin Issues: Easy Solutions for Glowing Skin](https://www.myalloy.com/blog/expert-tips-for-menopause-skin-care-during-perimenopause-and-menopause)
- [Skincare Routine | M4](https://www.myalloy.com/blog/why-estrogen-belongs-in-your-skincare-routine-and-not-just-in-your-hormone)
- [The First and Only Eye Cream with Estriol | Skincare Innovation](https://www.myalloy.com/blog/the-first-and-only-eye-cream-with-estriol)

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*This is a markdown version of [https://www.myalloy.com/knowledge-base/evidence-for-m4-estreal-face-cream-in-menopausal-skin](https://www.myalloy.com/knowledge-base/evidence-for-m4-estreal-face-cream-in-menopausal-skin) for AI/LLM consumption.*