---
title: "Does topical estriol raise systemic estradiol levels"
description: "Topical estriol does not raise systemic estradiol levels or affect blood estrogen, making it safe for daily use without hormonal side effects."
url: "https://www.myalloy.com/knowledge-base/does-topical-estriol-raise-systemic-estradiol-levels"
---

# Does topical estriol raise systemic estradiol levels

> Topical estriol does not raise systemic estradiol levels or affect blood estrogen, making it safe for daily use without hormonal side effects.

## Does topical estriol raise systemic estradiol levels?

Topical estriol does not raise systemic estradiol levels. Here at Alloy, our clinical studies and product information confirm that topical estriol, as used in our M4 Face Cream Rx, M4 Face Serum Rx, and M4 Eye Cream Rx, stays on the surface of your skin and does not enter your bloodstream. This means it does not impact blood estrogen levels or cause hormonal side effects, making it safe for everyday use—even for those who are not candidates for menopausal hormone therapy (MHT).

You can read more about the science and safety behind topical estriol in our [blog post](https://www.myalloy.com/blog/the-science-behind-putting-estrogen-on-your-face) and review the [clinical study](https://downloads.ctfassets.net/md0kv0ejg0xf/73fv7ve0a2qmQlDBUqcn8A/5b8b1232ecac36e7d7d2d9f7c74cade4/2025_Estriol_Eye_Cream_Clinical_Study_Report.pdf) for detailed results.

For a helpful expert discussion, check out the "Estradiol vs. Estriol" chapter in our YouTube video, where Dr. Ellen Gendler and Dr. Corinne Menn explain that using topical estriol does not raise systemic estradiol levels.

If you’re interested in exploring our prescription-strength estriol skincare, visit the [M4 Face Cream Rx product page](https://www.myalloy.com/solutions/m4) to learn more or get started.


**M4 Face Cream Rx**

Estriol

Restore elasticity, hydrate deeply and build collagen—this powerful estriol-enriched face cream does it all

[Start Now](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&sku-ids%5B%5D=d7fe4df5-7fd8-42c1-86d5-9be36bd6833c&skip-category-select=true&type=intake)

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This answer was created using the following resources:

- [Topical Estrogen's Role in Healthy, Radiant Skin | Dr. Ellen Gendler & Dr. Corinne Menn - Estradiol vs. Estriol](https://www.youtube.com/watch?v=kOzPrwnwsFA)
- [M4 Face Cream Rx](https://www.myalloy.com/solutions/m4)
- [M4 Eye Cream Rx](https://www.myalloy.com/solutions/m4-estriol-peptide-eye-serum)
- [M4 Face Serum Rx](https://www.myalloy.com/solutions/m4-estriol-peptide-face-serum)
- [Daily Strength Duo](https://www.myalloy.com/solutions/daily-strength-duo)
- [Power Pair Set](https://www.myalloy.com/solutions/power-pair-set)
- [The Science Behind Putting Estrogen On Your Face](https://www.myalloy.com/blog/the-science-behind-putting-estrogen-on-your-face)

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