---
title: "Does topical estriol cream lead to systemic hormone absorption"
description: "Does topical estriol cream cause systemic absorption? Learn how estriol skin cream stays local, supports skin, and does not raise estrogen levels."
url: "https://www.myalloy.com/knowledge-base/does-topical-estriol-cream-lead-to-systemic-hormone-absorption"
---

# Does topical estriol cream lead to systemic hormone absorption

> Does topical estriol cream cause systemic absorption? Learn how estriol skin cream stays local, supports skin, and does not raise estrogen levels.

## Does topical estriol cream lead to systemic hormone absorption?

Topical estriol creams, like the ones we use here at Alloy, stay local to the skin and do **not** raise systemic estrogen levels. This has been shown repeatedly in studies of facial estriol and in decades of data on vaginal estradiol, which is actually a much stronger form of estrogen.

Dr. Ellen Gendler and Dr. Corinne Menn talk about this quite a bit. In testing, serum estrogen levels stay unchanged, and absorption becomes even less likely as the skin thickens and gets healthier with use. If you want to hear them explain it directly, the *Topical Estrogen Safety* chapter from our YouTube event might be helpful because they walk through exactly why the cream stays local[Watch the chapter](https://www.youtube.com/watch?v=voedsMd4Zsc&t=2345s).


[Watch video](https://www.youtube.com/watch?v=voedsMd4Zsc&t=2345s)

For more detail on our estriol face cream, you can visit the M4 Face Cream page:[M4 Face Cream Rx](https://www.myalloy.com/solutions/m4).


**M4 Face Cream Rx**

Estriol

Restore elasticity, hydrate deeply and build collagen—this powerful estriol-enriched face cream does it all

[Start Now](https://secure.myalloy.com/experience?categories%5B%5D=skin-health&sku-ids%5B%5D=d7fe4df5-7fd8-42c1-86d5-9be36bd6833c&skip-category-select=true&type=intake)

So the short answer is yes, you get the skin benefits without systemic hormone exposure.

[Find Your Plan](https://secure.myalloy.com/experience)

---

This answer was created using the following resources:

- [A New Approach to Aging with Alloy - Topical Estrogen Safety](https://www.youtube.com/watch?v=voedsMd4Zsc)
- [Topical Estrogen's Role in Healthy, Radiant Skin | Dr. Ellen Gendler & Dr. Corinne Menn - Research & Safety of Topical Estrogen](https://www.youtube.com/watch?v=kOzPrwnwsFA)
- [Skin Deep with Dr. Menn: Let's Talk Skincare & Estrogen | Dr. Corinne Menn - Who Can Use Topical Estrogen](https://www.youtube.com/watch?v=sW48U6HSkcc)
- [When’s the Best Time to Start Hormone Therapy? | Dr. Sharon Malone - Systemic vs. Topical Estrogen](https://www.youtube.com/watch?v=SHrdy2O3Wh0)
- [Why Estriol + Tretinoin Make a Great Team - Topical Estrogen Effects](https://www.youtube.com/watch?v=Jtxthm1hpdk)
- [What Menopause Does to Your Skin & How to Fix It | Dr. Corinne Menn - Estrogen Therapy for Skin](https://www.youtube.com/watch?v=iAyFS_D6jvA)
- [From the Inside Out: Skin, Hair & Hormones | Dr. Deepti Gandhi - Topical Estriol for Skin](https://www.youtube.com/watch?v=MyxNnGi-XpE)
- [The Science Behind Putting Estrogen On Your Face](https://www.myalloy.com/blog/the-science-behind-putting-estrogen-on-your-face)
- [Topical Estrogen: Tips from Dr. Ellen Gendler](https://www.myalloy.com/blog/why-topical-estrogen-should-be-part-of-your-skincare)
- [Estradiol Cream or Patches? Find the Best Option for You](https://www.myalloy.com/blog/estradiol-cream-vs-estradiol-patches-whats-the-difference-and-which-should)
- [What Is Estradiol?](https://www.myalloy.com/blog/what-is-estradiol)

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