---
title: "The Science Behind Putting Estrogen On Your Face"
description: "Is it safe? YES - you can put estriol cream on your face, and you can buy it here. Studies have confirmed that like local, topical vaginal estradiol, topical facial estriol does not increase systemic serum levels of estrogen"
url: "https://www.myalloy.com/blog/the-science-behind-putting-estrogen-on-your-face"
---

# The Science Behind Putting Estrogen On Your Face

*Can you put estriol cream or estrogen gel on your face? *

By Monica Molenaar

## Summary

**Topical estriol cream** offers a targeted approach to improving skin health for women experiencing **menopause** or **perimenopause**, addressing estrogen deficiency that leads to collagen loss, reduced skin elasticity, and increased wrinkles. Clinical studies demonstrate that topical estriol increases collagen production, restores moisture, and enhances firmness without raising systemic estrogen levels or causing hormonal side effects, making it suitable even for those not on menopausal hormone therapy (MHT). Additional ingredients like glycerin and vitamin E further support skin hydration and protection.

Most Alloy customers see significant improvements in their skin within 3 months.  

[Find Your Plan](https://secure.myalloy.com/experience)

Here’s why our revolutionary face cream works

### **Did you know…**

Up to 30% of dermal collagen is lost during the first 5 years of menopause?

It decreases by an additional 2.1% every year after that.

[Studies have shown that estrogen deficiency is associated with a dramatic reduction in skin health and wellness.](https://pubmed.ncbi.nlm.nih.gov/33242128/)

### **That’s where estriol cream comes in.**

The solution to losing estrogen is replenishing it. And the benefits of MHT on skin aging are [well-documented](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685269/). Research has shown that topical estriol can help maintain skin health by increasing collagen production, retaining and restoring skin moisture, increasing skin firmness and elasticity, and decreasing pore size and wrinkle depth. 

[In one study](https://pubmed.ncbi.nlm.nih.gov/8876303/), after 6 months of topical estrogen use, skin elasticity and firmness had improved and wrinkle depth and pore size had decreased by 61-100%.

### **Is it safe to put estriol on your face?**

YES. Even if you’re not a candidate for MHT, you can use estriol face cream. Studies have confirmed that like local, topical vaginal estradiol, topical facial estriol does not increase systemic serum levels of estrogen. [There are no hormonal side effects](https://pubmed.ncbi.nlm.nih.gov/8876303/).

### **Can I combine M4 with my MHT?**

YES. Because studies have confirmed that local, topical vaginal estradiol, does not increase systemic serum levels of estrogen, you can use [M4 cream](https://www.myalloy.com/solutions/m4) alone or with other MHT.

![Tretinoin bottle](https://images.ctfassets.net/md0kv0ejg0xf/1DkbmzuUXkCSZRQTzyF0Fw/b02077ddbd0f3e14f7bc63539799597c/Product_Images__2_.png)

### **What else is in M4?**

**Glycerin**: It’s an excellent humectant. It attracts moisture and locks it into the top layer of your skin, leaving it hydrated.

**Vitamin E**: Stops skin from losing moisture, protects cells from UV damage, and softens skin.

## Citations

1. Lephart, E. D., & Naftolin, F. (2020). Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin. Dermatology and Therapy, 11(1), 53–69 — [View source](https://doi.org/10.1007/s13555-020-00468-7)
2. Stevenson, S., & Thornton, J. (2007). Effect of estrogens on skin aging and the potential role of SERMs. Clinical Interventions in Aging, 2(3), 283–297. — [View source](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685269/)
3. Schmidt, J. B., Binder, M., Demschik, G., Bieglmayer, C., & Reiner, A. (1996). Treatment of skin aging with topical estrogens. International Journal of Dermatology, 35(9), 669–674. — [View source](https://doi.org/10.1111/j.1365-4362.1996.tb03701.x)

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*This is a markdown version of [https://www.myalloy.com/blog/the-science-behind-putting-estrogen-on-your-face](https://www.myalloy.com/blog/the-science-behind-putting-estrogen-on-your-face) for AI/LLM consumption.*